DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32066 and CYRIA

DIOPT Version :9

Sequence 1:	NP_729619.1	Gene:	CG32066 / 39206	FlyBaseID:	FBgn0052066	Length:	324	Species:	Drosophila melanogaster
Sequence 2:	NP_110424.1	Gene:	CYRIA / 81553	HGNCID:	25373	Length:	323	Species:	Homo sapiens

Alignment Length:	329	Identity:	172/329 - (52%)
Similarity:	228/329 - (69%)	Gaps:	14/329 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGKLLSLLSRDDSNCCAAKSY-DVFLDFENAAPTETERAVYDEVERVLRESEVVLDEIQIYRGAG 64
            ||.||.:|:|:..|      | ..|||||||.|||.||.:::::..||::||.:|.::|.|:|||
Human     1 MGNLLKVLTREIEN------YPHFFLDFENAQPTEGEREIWNQISAVLQDSESILADLQAYKGAG 59

  Fly    65 KEIREAIADPSP-EVTAKAWAAVLPLVNKLKRCYEHSMELDKIVPKLLGQLVGGKLNPTQHLETQ 128
            .|||:||.:|:. ::..|||.||.|||.:|||.||.|:.|:|.:..||..|......||||||.:
Human    60 PEIRDAIQNPNDIQLQEKAWNAVCPLVVRLKRFYEFSIRLEKALQSLLESLTCPPYTPTQHLERE 124

  Fly   129 QALVKQLAEILEFVLKFDEYKMKTPAIQNDFSYYRRIVSRQRVDS----TENMLVSTELANRMSL 189
            |||.|:.||||.|.|:|||.||:.||||||||||||.:||.|:::    .||. |:.|:||||||
Human   125 QALAKEFAEILHFTLRFDELKMRNPAIQNDFSYYRRTISRNRINNMHLDIENE-VNNEMANRMSL 188

  Fly   190 FYAHATPMLKVLSEATSKFVNDNAD-DVQNTTETLGTMAKVCLRMLENPKLLQQIEREDTKMLVL 253
            |||.||||||.||.||..||::|.. .::|||:.|.||..||..|||.|:...:...|:|.|..:
Human   189 FYAEATPMLKTLSNATMHFVSENKTLPIENTTDCLSTMTSVCKVMLETPEYRSRFTSEETLMFCM 253

  Fly   254 RVMVGLVILYDHVHPEGAFVRGAHVDVKGCVRLLQAQPAIKAEPLLNALRYTTKHLNGENTPKNI 318
            |||||::||||||||.|||.:.:.:|:|||:::|:.|.....|.||||||:||||||.|:|.|.|
Human   254 RVMVGVIILYDHVHPVGAFCKTSKIDMKGCIKVLKEQAPDSVEGLLNALRFTTKHLNDESTSKQI 318

  Fly   319 QRLL 322
            :.:|
Human   319 RAML 322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32066	NP_729619.1	DUF1394	22..319	CDD:399855	162/302 (54%)
CYRIA	NP_110424.1	DUF1394	17..319	CDD:399855	162/302 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156949
Domainoid	1	1.000	331	1.000	Domainoid score	I1146
eggNOG	1	0.900	-	-		E1_KOG3951
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	336	1.000	Inparanoid score	I2402
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54626
OrthoDB	1	1.010	-	-		D1129868at2759
OrthoFinder	1	1.000	-	-		FOG0002340
OrthoInspector	1	1.000	-	-		otm40475
orthoMCL	1	0.900	-	-		OOG6_103389
Panther	1	1.100	-	-	O	PTHR12422
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5116
SonicParanoid	1	1.000	-	-		X1542
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800