Protein Alignment E(z) and SETDB1

DIOPT Version :10

• Sequence 1: NP_001261682.1
• Gene: E(z) / 39203
• FlyBaseID: FBgn0000629
• Length: 765
• Species: Drosophila melanogaster
• Sequence 2: NP_001353346.1
• Gene: SETDB1 / 9869
• HGNCID: 10761
• Length: 1292
• Species: Homo sapiens
• Alignment Length: 737
• Identity: 147/737 - (19%)
• Similarity: 229/737 - (31%)
• Gaps: 262/737 - (35%)

  Fly    63 YDPPHVDCVKRAEVTSYNGIPSGPQKVPICVINAVTPIPTMYTWAPTQ----QNFMVEDETVLHN 123
            :|..:...|.::|:            .|||       .|...||...:    ::|:.|..|...|
Human   297 FDDGYASYVTQSEL------------YPIC-------RPLKKTWEDIEDISCRDFIEEYVTAYPN 342

  Fly   124 IPYMGDEVLDKDGKFI---------EELIKNYDGKVHGDKDPSFMDDAIFVELVHALMRSYSKEL 179
            .|.    ||.|.|:.|         :..::..||.:   ....|:||               |..
Human   343 RPM----VLLKSGQLIKTEWEGTWWKSRVEEVDGSL---VRILFLDD---------------KRC 385

  Fly   180 EEAAPGTAT-----AIKTETLA--KSKQGE-----DDGVVDVDADGESPMKLEKTDSKGDLTEVE 232
            |....|:..     ::||.:.:  :.|||:     :.|.|    ..:.|:.....|..|..|:.:
Human   386 EWIYRGSTRLEPMFSMKTSSASALEKKQGQLRTRPNMGAV----RSKGPVVQYTQDLTGTGTQFK 446

  Fly   233 KKETEEPLETEDADVKPDVEEVKDKLPFP--APIIFQAISANFPDKGTAQELKEKYIELTE---- 291
            ..|..:|    .|...|         |||  .|:..||..:...:...||..|:...:.|.
Human   447 PVEPPQP----TAPPAP---------PFPPAPPLSPQAGDSESLESQLAQSRKQVAKKSTSFRPG 498

  Fly   292 -----HQDPERPQECTPNIDGIKAESVSRERTMHS----------------------FHTLFCRR 329
                 |..|..| ..:.|:.|.|.   ...:|..|                      ||.:..|
Human   499 SVGSGHSSPTSP-ALSENVSGGKP---GINQTYRSPLGSTASAPAPSALPAPPAPPVFHGMLER- 558

  Fly   330 CFKYDCFLHRHHVQGLQGHAGPNLQKRRYPELKPFAEP--CSNSCYMLIDGMKEKLAADSKTPPI 392
                                .|.....|.|..|.|..|  ||.:|...:..|:
Human   559 --------------------APAEPSYRAPMEKLFYLPHVCSYTCLSRVRPMR------------ 591

  Fly   393 DSCNEASSEDSNDSNSQFSNKDFNHENSKDNGLTV-------NSAAVAEINSIMAGMMNITSTQC 450
                          |.|:..|         |.|.|       ...|...:|..| |...|..|.|
Human   592 --------------NEQYRGK---------NPLLVPLLYDFRRMTARRRVNRKM-GFHVIYKTPC 632

  Fly   451 -VWTGADQALYRVLHK-----VYLKNYCAIAHNMLTKTCRQVYEFAQKEDAEFSFEDL------R 503
             :.....|.:.|.|.:     ::|:.:|...:.::.:..:....|....|..:..||:      .
Human   633 GLCLRTMQEIERYLFETGCDFLFLEMFCLDPYVLVDRKFQPYKPFYYILDITYGKEDVPLSCVNE 697

  Fly   504 QDFT-PPRKKKKKQRLWSLHCRKIQLKKDSSSNHVYNYTPCDHPGHPCDMNCSCIQTQNFCEKFC 567
            .|.| ||:....|:|:                           ||....:|..       .|...
Human   698 IDTTPPPQVAYSKERI---------------------------PGKGVFINTG-------PEFLV 728

  Fly   568 NCSSDCQNRFPGCRCKAQCNTKQ-----CPC-------------YLAVRECDPDLCQACGADQFK 614
            .|  ||::   |||.|::|...|     ..|             |..:.||.|.....|. .:.|
Human   729 GC--DCKD---GCRDKSKCACHQLTIQATACTPGGQINPNSGYQYKRLEECLPTGVYECN-KRCK 787

  Fly   615 LTKITCKNVCVQRGLHKHLLMAPSDIAGWGIFLKEGAQKNEFISEYCGEIISQDEADRRG-KVYD 678
            .....|.|..||.||...|.:..:...||||...:...|..|:..|.|:|::.|.||:.| ::.|
Human   788 CDPNMCTNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDDFADKEGLEMGD 852

  Fly   679 KYMCSFLFNLNNDFVVDATRKG 700
            :|..    ||::...|:..::|
Human   853 EYFA----NLDHIESVENFKEG 870

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(z)	NP_001261682.1	PRC2_HTH_1	151..291	CDD:436286	30/153 (20%)
		SANT	452..492	CDD:238096	6/44 (14%)
		preSET_CXC	579..610	CDD:408079	12/48 (25%)
		SET_EZH2	628..747	CDD:380995	22/74 (30%)
SETDB1	NP_001353346.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	108..147
		DUF5604	193..250	CDD:408109
		Tudor_SETDB1_rpt1	260..341	CDD:410453	12/62 (19%)
		Tudor_SETDB1_rpt2	348..401	CDD:410548	11/70 (16%)
		MBD	598..673	CDD:128673	16/84 (19%)
		SET_SETDB1	675..>876	CDD:380915	56/240 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	869..1161		1/2 (50%)
		SET	<1203..1292	CDD:394802