Protein Alignment E(z) and MEA

DIOPT Version :10

• Sequence 1: NP_001261682.1
• Gene: E(z) / 39203
• FlyBaseID: FBgn0000629
• Length: 765
• Species: Drosophila melanogaster
• Sequence 2: NP_563658.1
• Gene: MEA / 839422
• AraportID: AT1G02580
• Length: 689
• Species: Arabidopsis thaliana
• Alignment Length: 719
• Identity: 216/719 - (30%)
• Similarity: 316/719 - (43%)
• Gaps: 166/719 - (23%)

  Fly   100 IPTMYTWAPTQQNF-----MVED-------------ETVLHNIPYMGD--------EVLDKDGKF 138
            ||::.|.|...|:|     ..||             :..|.:.....|        .|||:|..:
plant    41 IPSVATHASHHQSFDLNQPAAEDDNGGDNKSLLSRMQNPLRHFSASSDYNSYEDQGYVLDEDQDY 105

  Fly   139 -IEELIKNYDGKVHGDKDPSFMDDAIFVELVHALMRSYSKELEEAAPGTATAIKTETLAKSKQ-- 200
             :||.:            |.|:|:.:      .|:.|....:.|..|.:.|.:.|    ||.|
plant   106 ALEEDV------------PLFLDEDV------PLLPSVKLPIVEKLPRSITWVFT----KSSQLM 148

  Fly   201 GEDDGVVDVDADGESPMKLEKTDSKGDLTEVEKKETEEPLETEDADVKPDVEEVKDKLPFPAPI- 264
            .|.|.|:.         |.:.....|:..|:..:|.||..|.::.::|      |:|..|...:
plant   149 AESDSVIG---------KRQIYYLNGEALELSSEEDEEDEEEDEEEIK------KEKCEFSEDVD 198

  Fly   265 -IFQAISANFP-DKGTAQELKEKYIELTEHQDPERPQECTPNIDGIKAESVSRERTMHSFHTLF- 326
             ....:..::. |....:....||:|:......||..|.....||...|  :.:.|..:..|.|
plant   199 RFIWTVGQDYGLDDLVVRRALAKYLEVDVSDILERYNELKLKNDGTAGE--ASDLTSKTITTAFQ 261

  Fly   327 -------CRRCFKYDCFLHRHHVQGLQGHAGPNLQKRRYPELKPF------AEPCSNSCYMLIDG 378
                   ||||..:||.:|..:.           .:.|..|.|..      .:|||..||:.:..
plant   262 DFADRRHCRRCMIFDCHMHEKYE-----------PESRSSEDKSSLFEDEDRQPCSEHCYLKVRS 315

  Fly   379 MKEKLAADSKTPPIDSCNEASSEDSNDSNSQFSNKDFNHENSKDNGLTVNSAAVAEINSIMAGMM 443
            :.|   ||                              |....||.:: |...|::.|:.|
plant   316 VTE---AD------------------------------HVMDNDNSIS-NKIVVSDPNNTM---- 342

  Fly   444 NITSTQCVWTGADQALYRVLHKVYLKNYCAIAHNML--TKTCRQVYEFAQKEDAEFSFEDLR--- 503
                    ||..::.||....:::.:|.|.:|.|:|  .|||.::|.:.:::|......||.
plant   343 --------WTPVEKDLYLKGIEIFGRNSCDVALNILRGLKTCLEIYNYMREQDQCTMSLDLNKTT 399

  Fly   504 QDFTPPRKK---------KKKQRLWSLHCRKIQLKKDSSSNHVY--NYTPCDHPGHPCDMNCSCI 557
            |......||         :||.||.........|||.:|....:  :||||.... .|...|.|:
plant   400 QRHNQVTKKVSRKSSRSVRKKSRLRKYARYPPALKKTTSGEAKFYKHYTPCTCKS-KCGQQCPCL 463

  Fly   558 QTQNFCEKFCNCSSDCQNRFPGCRCK-AQCNTKQCPCYLAVRECDPDLCQAC------GADQFKL 615
            ..:|.|||:|.||.||.|||.||.|. .||..:||||:.|.||||||||::|      |......
plant   464 THENCCEKYCGCSKDCNNRFGGCNCAIGQCTNRQCPCFAANRECDPDLCRSCPLSCGDGTLGETP 528

  Fly   616 TKITCKNVCVQRGLHKHLLMAPSDIAGWGIFLKEGAQKNEFISEYCGEIISQDEADRRGKVYDKY 680
            .:|.|||:......:|.:|:..||:.|||.|..:..:|||::.||.||:|:.|||:.||::.|:.
plant   529 VQIQCKNMQFLLQTNKKILIGKSDVHGWGAFTWDSLKKNEYLGEYTGELITHDEANERGRIEDRI 593

  Fly   681 MCSFLFNLNNDFVVDATRKGNKIRFANHSINPNCYAKVMMVTGDHRIGIFAKRAIQPGEELFFDY 745
            ..|:||.||:...:||.||||:.:|.|||..||||||:|:|.||.|||:||:|||:.||||||||
plant   594 GSSYLFTLNDQLEIDARRKGNEFKFLNHSARPNCYAKLMIVRGDQRIGLFAERAIEEGEELFFDY 658

  Fly   746 RYGP 749
            .|||
plant   659 CYGP 662

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(z)	NP_001261682.1	PRC2_HTH_1	151..291	CDD:436286	30/144 (21%)
		SANT	452..492	CDD:238096	13/41 (32%)
		preSET_CXC	579..610	CDD:408079	19/37 (51%)
		SET_EZH2	628..747	CDD:380995	63/118 (53%)
MEA	NP_563658.1	preSET_CXC	485..515	CDD:408079	18/29 (62%)
		SET_EZH	544..660	CDD:380917	63/115 (55%)