DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment E(z) and KMT2D

DIOPT Version :10

Sequence 1:NP_001261682.1 Gene:E(z) / 39203 FlyBaseID:FBgn0000629 Length:765 Species:Drosophila melanogaster
Sequence 2:NP_003473.3 Gene:KMT2D / 8085 HGNCID:7133 Length:5537 Species:Homo sapiens


Alignment Length:139 Identity:46/139 - (33%)
Similarity:78/139 - (56%) Gaps:10/139 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly   610 ADQFKLTKITCKNVCVQRGLHKHLLMAPSDIAGWGIFLKEGAQKNEFISEYCGEIISQDEADRRG 674
            :.|::..:...||         ::.:|.|.|.|.|::..:..:|:..:.||.|.||..:.|:||.
Human  5385 SSQYRRLRTEWKN---------NVYLARSRIQGLGLYAAKDLEKHTMVIEYIGTIIRNEVANRRE 5440

  Fly   675 KVYDKYMCS-FLFNLNNDFVVDATRKGNKIRFANHSINPNCYAKVMMVTGDHRIGIFAKRAIQPG 738
            |:|::.... ::|.:||:.|:|||..|...|:.|||..|||.|:|:....:.:|.|.:.|.|..|
Human  5441 KIYEEQNRGIYMFRINNEHVIDATLTGGPARYINHSCAPNCVAEVVTFDKEDKIIIISSRRIPKG 5505

  Fly   739 EELFFDYRY 747
            |||.:||::
Human  5506 EELTYDYQF 5514

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
E(z)NP_001261682.1 PRC2_HTH_1 151..291 CDD:436286
SANT 452..492 CDD:238096
preSET_CXC 579..610 CDD:408079 46/139 (33%)
SET_EZH2 628..747 CDD:380995 43/119 (36%)
KMT2DNP_003473.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..60
ePHD1_KMT2D 134..217 CDD:277165
PHD1_KMT2C_like 228..273 CDD:276984
PHD_SF 275..320 CDD:473978
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 368..387
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 393..416
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 436..1331
15 X 5 AA repeats of S/P-P-P-E/P-E/A 439..668
PHA03247 <469..860 CDD:223021
PHA03247 <690..1272 CDD:223021
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1340..1359
PHD3_KMT2D 1378..1428 CDD:277072
PHD5_KMT2C_like 1429..1475 CDD:276988
PHD5_KMT2D 1506..1556 CDD:277074
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1610..1767
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1793..1889
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1904..2002
HMG-box_KMT2D 1995..2078 CDD:438836
PHA03247 <2108..2600 CDD:223021
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2165..2683
LXXLL motif 1 2686..2690
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2697..2814
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2835..2996
LXXLL motif 2 3038..3042
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3078..3110
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3147..3209
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3263..3339
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3462..3499
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3596..3673
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3758..3802
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3984..4191
PHA03247 <4162..4426 CDD:223021
LXXLL motif 3 4222..4226
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4233..4398
LXXLL motif 4 4253..4257
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4410..4452
LXXLL motif 5 4463..4467
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4503..4544
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4613..4727
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4822..4857
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4905..4980
LXXLL motif 6 4990..4994
ePHD2_KMT2D 5032..5138 CDD:277168
FYRN 5181..5232 CDD:461787
FYRC 5240..5327 CDD:197781
WDR5 interaction motif (WIN). /evidence=ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:22665483 5337..5342
SET_KMT2D 5382..5536 CDD:380986 46/139 (33%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.