Protein Alignment E(z) and Ehmt1

DIOPT Version :10

• Sequence 1: NP_001261682.1
• Gene: E(z) / 39203
• FlyBaseID: FBgn0000629
• Length: 765
• Species: Drosophila melanogaster
• Sequence 2: XP_006498485.1
• Gene: Ehmt1 / 77683
• MGIID: 1924933
• Length: 1312
• Species: Mus musculus
• Alignment Length: 837
• Identity: 176/837 - (21%)
• Similarity: 271/837 - (32%)
• Gaps: 261/837 - (31%)

  Fly    77 TSYNGIPSGP--------QKVPICVINAVTPIPTMYTWAPTQQNFMVEDETVLHNIPYMGDEVLD 133
            |...|:.|||        |:||:|.....||              ...:.:.|.|...|..|.:|
Mouse   513 TENEGLASGPDVLGTDGLQEVPLCSCRMETP--------------KSREISTLANNQCMATESVD 563

  Fly   134 KD-GKFIEELIKNYDGKVHGDKDP----------------------------SFMDDAIFVELVH 169
            .: |:....::| |:.....:|.|                            :||:......:.|
Mouse   564 HELGRCTNSVVK-YELMRPSNKAPLLVLCEDHRGRMVKHQCCPGCGYFCTAGNFMECQPESSISH 627

  Fly   170 ALMR-------------------SYSKELEEA----------APGTATAIKTETLAKSKQGEDDG 205
            ...:                   |.:||:..|          |||...::..|..|.:..|...|
Mouse   628 RFHKDCASRVNNASYCPHCGEEASKAKEVTIAKADTTSTVTLAPGQEKSLAAEGRADTTTGSIAG 692

  Fly   206 V-VDVDADGESPMKLEKTDSKG---------DLTEVEKKETEEPLETEDADVKPDVEEVKDKLPF 260
            . .|..:...:|...|..|..|         .|::...|||     .|.|.:..|.|:.| ||.|
Mouse   693 APEDERSQSTAPQAPECFDPAGPAGLVRPTSGLSQGPGKET-----LESALIALDSEKPK-KLRF 751

  Fly   261 -PAPIIFQAISANFPDKGTAQELKEKYIELTEHQDPERPQECTPNIDGIKAESVSRERTMHSF-- 322
             |..:.|.|...         ||::..:.|.:..||           ..|.|..|:...:|:.
Mouse   752 HPKQLYFSARQG---------ELQKVLLMLVDGIDP-----------NFKMEHQSKRSPLHAAAE 796

  Fly   323 --HTLFCRRCFKYDCFLHRHHVQGLQGHAGPNLQKRRYPELKPFAEPCSNSCYMLIDGMKEKLAA 385
              |...|....:                ||.|:......:..|..|...|:   .:|.:|..:.|
Mouse   797 AGHVDICHMLVQ----------------AGANIDTCSEDQRTPLMEAAENN---HLDAVKYLIKA 842

  Fly   386 DSKTPPID----SCNEASSEDSNDSNSQF--SNKDFNHENSKDNGLTVNSAAV----AEINSIMA 440
            .::..|.|    :|...:::..:....|:  ||...:.....|.|.|....|.    .|:..::.
Mouse   843 GAQVDPKDAEGSTCLHLAAKKGHYDVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVELVKLLL 907

  Fly   441 GM---MNITSTQ---CVWTGADQALYRVLHKVYLKNYCAIAHNMLTKTC---------RQVYEFA 490
            ..   :||...:   |            ||.........||..:|...|         ......|
Mouse   908 SKGSDINIRDNEENIC------------LHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIA 960

  Fly   491 QKE------------DAEFSFEDLRQDFTPPRKKKKKQRLWS-LHCRK----------IQLKKDS 532
            .:|            |::.:.:: ::..||.:......::|| |...|          :.::|..
Mouse   961 ARENRYDCVVLFLSRDSDVTLKN-KEGETPLQCASLSSQVWSALQMSKALRDSAPDKPVAVEKTV 1024

  Fly   533 SSNHVYNY----TPCDH--PGHPCDMNCSCIQTQNFCEKFCNCSSDCQN------RFPGCRCKAQ 585
            |.:....|    .||.:  ....|..|...:..        ||.:...|      ....|.|...
Mouse  1025 SRDIARGYERIPIPCVNAVDSELCPTNYKYVSQ--------NCVTSPMNIDRNITHLQYCVCVDD 1081

  Fly   586 CNTKQCPCYLAVREC---------------DPDL---C-QACGADQFKLTKITCKNVCVQRGLHK 631
            |::..|.|......|               :|.|   | .||...:      .|:|..||.||..
Mouse  1082 CSSSTCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWR------NCRNRVVQNGLRA 1140

  Fly   632 HLLMAPSDIAGWGIFLKEGAQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNND----F 692
            .|.:..:...|||:...:......|:.||.||:||..|||.|.:      .|:||:|:|.    :
Mouse  1141 RLQLYRTQDMGWGVRSLQDIPLGTFVCEYVGELISDSEADVREE------DSYLFDLDNKDGEVY 1199

  Fly   693 VVDATRKGNKIRFANHSINPNCY-AKVMMVTGD---HRIGIFAKRAIQPGEELFFDY 745
            .:||...||..||.||...||.. .:|.|...|   .||..|:.|.||.||:|.|||
Mouse  1200 CIDARFYGNVSRFINHHCEPNLVPVRVFMSHQDLRFPRIAFFSTRLIQAGEQLGFDY 1256

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(z)	NP_001261682.1	PRC2_HTH_1	151..291	CDD:436286	39/207 (19%)
		SANT	452..492	CDD:238096	7/48 (15%)
		preSET_CXC	579..610	CDD:408079	11/49 (22%)
		SET_EZH2	628..747	CDD:380995	47/126 (37%)
Ehmt1	XP_006498485.1	EHMT_ZBD	530..660	CDD:411018	22/144 (15%)
		ANKYR	734..990	CDD:440430	55/308 (18%)
		ANK repeat	788..817	CDD:293786	6/44 (14%)
		ANK repeat	819..850	CDD:293786	7/33 (21%)
		ANK repeat	852..884	CDD:293786	4/31 (13%)
		ANK repeat	886..917	CDD:293786	6/30 (20%)
		ANK repeat	919..950	CDD:293786	7/42 (17%)
		ANK repeat	952..983	CDD:293786	3/30 (10%)
		SET_EHMT1	1050..1280	CDD:380933	66/227 (29%)