DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment E(z) and ezh1

DIOPT Version :9

Sequence 1:	NP_001261682.1	Gene:	E(z) / 39203	FlyBaseID:	FBgn0000629	Length:	765	Species:	Drosophila melanogaster
Sequence 2:	NP_001035072.2	Gene:	ezh1 / 664754	ZFINID:	ZDB-GENE-050114-1	Length:	756	Species:	Danio rerio

Alignment Length:	812	Identity:	398/812 - (49%)
Similarity:	500/812 - (61%)	Gaps:	130/812 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 EWKRRVKSEYIKIRQQKRYKRADEIKEAWIRNWDEHNHNVQDLYCE--SKVW-----QAKPYDPP 66
            |||:||||||:::||.||:::|:::|..:     :.|....::..|  ::.|     |:.|....
Zfish    20 EWKKRVKSEYMRLRQLKRFRKAEQVKALF-----QSNRRKIEVGTELLNEEWSKLRIQSIPLSTS 79

  Fly    67 HVDCVKRAEVTSYNGIPSGP-QKVPICVINAVTPIPTMYTWAPTQQNFMVEDETVLHNIPYMGDE 130
            ......:.......|.||.| |.|.:..:..|..||.||:|:|.||||||||||.||||||||||
Zfish    80 SGSLPSKKLCMVEFGFPSFPNQAVAMRPLTTVAGIPFMYSWSPLQQNFMVEDETFLHNIPYMGDE 144

  Fly   131 VLDKDGKFIEELIKNYDGKVHGDK-------DPSFMDDAIFVELVHALMRSYS---KELEEAAPG 185
            ||::|..|:||||.|||| ||||:       :..|::|.||.|||.||.: ||   :|.||..|.
Zfish   145 VLEQDEAFLEELIDNYDG-VHGDRVSCTFLIEGGFINDEIFKELVEALSQ-YSDPEEEEEEKEPT 207

  Fly   186 TATAIKTETLAKSKQGEDDGVVDVDADGESPMKLEKTDSKGDLTEVEKKETEEPLETEDADVK-- 248
            .|        |::||.|:                         .|::|...|.|.|::.|..|
Zfish   208 DA--------AENKQEEE-------------------------KEMQKSAAEAPEESKTAFFKRK 239

  Fly   249 ----PDVEEVKDKLPFPAPIIFQAISANFPDKGTAQELKEKYIELTEHQDPER-PQECTPNIDGI 308
                .:..|:......|...||.||::.||.|||.||||:||::|.|..:..: |..||||:||.
Zfish   240 WRNTAEGRELSANKKIPHDKIFTAIASMFPYKGTMQELKDKYLDLLEPSNHVKLPPLCTPNMDGP 304

  Fly   309 KAESVSRERTMHSFHTLFCRRCFKYDCFLHRHHVQGLQGHAGPNLQKRRYPELKPFAEPCSNSCY 373
            .|:||.||:::|||||||||||||||||||..       |:.||:.||:..|:....|||...|:
Zfish   305 FAKSVQREQSLHSFHTLFCRRCFKYDCFLHPF-------HSSPNVYKRKSKEIHMETEPCGLDCF 362

  Fly   374 MLIDGMKE----KLAADSKT-------PPIDSCNEASSEDSNDSNSQFSNKDFNHENSKDNGLTV 427
            :|..|.||    .:....:|       .|..||.....:.|              |..|:.|...
Zfish   363 LLQKGAKEFADQNMMRSQRTRRRRRQPRPSSSCGHTPPDSS--------------EKGKEGGSDH 413

  Fly   428 NSAAVAEINSIMAGMMNI---------TSTQCVWTGADQALYRVLHKVYLKNYCAIAHNMLTKTC 483
            .:.:.:|.||.....:.:         :.:...|:||:::|:||||..|..|:|:||..:.||||
Zfish   414 ETTSSSEGNSRCPSPIKMKPGEEESKESKSPPQWSGAEESLFRVLHGTYYNNFCSIARLIGTKTC 478

  Fly   484 RQVYEFAQK---------EDAEFSFEDLRQDFTPPRKKKKKQRLWSLHCRKIQLKKDSSSNHVYN 539
            |:|||||.|         ||:..|          |:|||:|.|||:    |||||||:|||.|||
Zfish   479 REVYEFAVKEVLIDRMPLEDSGIS----------PQKKKRKHRLWA----KIQLKKDNSSNQVYN 529

  Fly   540 YTPCDHPGHPCDMNCSCIQTQNFCEKFCNCSSDCQNRFPGCRCKAQCNTKQCPCYLAVRECDPDL 604
            |.|||||.||||.:|.|:.|||||||||.|..:|||||||||||.||||||||||||||||||||
Zfish   530 YQPCDHPEHPCDSSCPCVITQNFCEKFCQCDRECQNRFPGCRCKTQCNTKQCPCYLAVRECDPDL 594

  Fly   605 CQACG-ADQFKLTKITCKNVCVQRGLHKHLLMAPSDIAGWGIFLKEGAQKNEFISEYCGEIISQD 668
            |..|| ||.:...:::|||..:||||.||||:||||:||||.|:||..||||||||||||:||||
Zfish   595 CMTCGAADHWDSKQVSCKNCSIQRGLKKHLLLAPSDVAGWGTFIKEPVQKNEFISEYCGELISQD 659

  Fly   669 EADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSINPNCYAKVMMVTGDHRIGIFAKR 733
            ||||||::|||||.|||||||||||||||||||||||||||:||||||||:||.|||||||||||
Zfish   660 EADRRGRIYDKYMSSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVVMVNGDHRIGIFAKR 724

  Fly   734 AIQPGEELFFDYRYGPTEQLKFVGIEREMEIV 765
            |||.||||||||||...:.||:||||||:|||
Zfish   725 AIQQGEELFFDYRYSQADALKYVGIEREIEIV 756

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(z)	NP_001261682.1	SANT	452..492	CDD:238096	23/39 (59%)
		SET	<471..745	CDD:225491	202/283 (71%)
		SET	631..747	CDD:214614	101/115 (88%)
ezh1	NP_001035072.2	EZH2_WD-Binding	45..73	CDD:288468	4/32 (13%)
		SANT	447..489	CDD:238096	24/41 (59%)
		SET	<476..736	CDD:225491	198/273 (73%)
		SET	622..743	CDD:214614	103/120 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	267	1.000	Domainoid score	I1830
eggNOG	1	0.900	-	-		E2759_KOG1079
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	796	1.000	Inparanoid score	I487
OMA	1	1.010	-	-		QHG49242
OrthoDB	1	1.010	-	-		D118331at33208
OrthoFinder	1	1.000	-	-		FOG0002374
OrthoInspector	1	1.000	-	-		otm26010
orthoMCL	1	0.900	-	-		OOG6_102137
Panther	1	1.100	-	-	O	PTHR45747
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1072
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.880