DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment E(z) and NSD3

DIOPT Version :10

Sequence 1:NP_001261682.1 Gene:E(z) / 39203 FlyBaseID:FBgn0000629 Length:765 Species:Drosophila melanogaster
Sequence 2:NP_075447.1 Gene:NSD3 / 54904 HGNCID:12767 Length:1437 Species:Homo sapiens


Alignment Length:956 Identity:197/956 - (20%)
Similarity:326/956 - (34%) Gaps:343/956 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 VKSEYIKIRQQKRYKRADE-----IKEAWIRNWDEHNHNVQDLYCESKVWQAKPYDPPHVDCVKR 73
            :.|..|:...|:|:..|:|     :|.||                  |...|:...|        
Human   442 LSSTEIRRHSQRRHTSAEEEEPPPVKIAW------------------KTAAARKSLP-------- 480

  Fly    74 AEVTSYNGIPSGPQKVPICVINAVTPIPTMYTWAPTQQNFMVEDETVLHNIPYMGDEVLDKDGKF 138
            |.:|.:.| ....||   |.::.|..|         :|.|.:::.|              .||||
Human   481 ASITMHKG-SLDLQK---CNMSPVVKI---------EQVFALQNAT--------------GDGKF 518

  Fly   139 IEELIKNYDGKVHGDKDPSFM--DDAIFVELVHALMRSYSKELE--EAAPGTATAIK-------- 191
            |::.:  |..|..|:|....:  .|.:.:...:......::.:.  ||..|:..:::        
Human   519 IDQFV--YSTKGIGNKTEISVRGQDRLIISTPNQRNEKPTQSVSSPEATSGSTGSVEKKQQRRSI 581

  Fly   192 ---------TETLAKS---------------KQGEDDGVVDVDADGESPMK--------LEKT-- 222
                     ||.:.|.               |.|...|..:: :|...|:|        :|.|  
Human   582 RTRSESEKSTEVVPKKKIKKEQVETVPQATVKTGLQKGASEI-SDSCKPLKKRSRASTDVEMTSS 645

  Fly   223 --------DSKG--DLTEVEKKETEEPLETEDADVKPDVEEVKDKLPFPAPIIFQAISANFPDKG 277
                    ||:|  ||.....|:.:.|..|.||||. ||               |::.::...:|
Human   646 AYRDTSDSDSRGLSDLQVGFGKQVDSPSATADADVS-DV---------------QSMDSSLSRRG 694

  Fly   278 TAQELKEKYIELTEHQ-DPERP--QECTPNID----GIKAESVSRERTMHSFHTLFCRRC--FKY 333
            |....|:...::.|.. |...|  .||..:..    |:.:...|:         ..|..|  .::
Human   695 TGMSKKDTVCQICESSGDSLIPCEGECCKHFHLECLGLASLPDSK---------FICMECKTGQH 750

  Fly   334 DCFLHRHHVQGLQ------GHAGPNLQK---RRYP----ELKPFAEP--CSNSCYMLID---GMK 380
            .||..:  |.|..      |..|....:   |::|    |.|.|..|  |.::|.|..|   ..|
Human   751 PCFSCK--VSGKDVKRCSVGACGKFYHEACVRKFPTAIFESKGFRCPQHCCSACSMEKDIHKASK 813

  Fly   381 EKLAADSKTPPI----DSCNEA------------SSEDSNDSNSQFSNKDF-----------NHE 418
            .::....:.|..    |:|..|            |:.....|||...|..|           :|.
Human   814 GRMMRCLRCPVAYHSGDACIAAGSMLVSSYILICSNHSKRSSNSSAVNVGFCFVCARGLIVQDHS 878

  Fly   419 NS-------KDNGLTVNSAAVAEINSI-MAGMMNITSTQC------------------------- 450
            :.       |.:.| :|.:..||:..: |....:.:..:|                         
Human   879 DPMFSSYAYKSHYL-LNESNRAELMKLPMIPSSSASKKKCEKGGRLLCCESCPASFHPECLSIEM 942

  Fly   451 ---VWTGADQALYRVLHK-----VYLKNY-------C----------AIAHNM------------ 478
               .|...|....:.||.     |.|.||       |          .:.|::            
Human   943 PEGCWNCNDCKAGKKLHYKQIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDLGDFPVFFFGSHD 1007

  Fly   479 -------------------------LTKTCRQVYEFAQKEDAEFSFEDLRQDFTPPRKKKKKQRL 518
                                     :.||.::..|.|.|.     |::|:      .:::.|:.|
Human  1008 YYWVHQGRVFPYVEGDKSFAEGQTSINKTFKKALEEAAKR-----FQELK------AQRESKEAL 1061

  Fly   519 WSLHCRKIQLKKDSSSNHVYNYTPCDHPGHPCDMNCSCIQTQNFCE-KFCNCSSDCQNRFPGCRC 582
                    :::|:|.....|.:...:..     :....||..:..| ..|||....:|   .|..
Human  1062 --------EIEKNSRKPPPYKHIKANKV-----IGKVQIQVADLSEIPRCNCKPADEN---PCGL 1110

  Fly   583 KAQCNTKQCPCYLAVRECDPDLCQACGADQFKLTKITCKNVCVQRGLHKHLLMAPSDIAGWGIFL 647
            :::|..:     :...||.|.:|.|  .|:       |:|.|..:.|:....:..::..|||:..
Human  1111 ESECLNR-----MLQYECHPQVCPA--GDR-------CQNQCFTKRLYPDAEIIKTERRGWGLRT 1161

  Fly   648 KEGAQKNEFISEYCGEIISQDEADRRGK-VYDKYMCSF-LFNLNNDFVVDATRKGNKIRFANHSI 710
            |...:|.||::||.||:|.::|...|.| .::..:.:| :..:..|.::||..|||..||.|||.
Human  1162 KRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSC 1226

  Fly   711 NPNCYAKVMMVTGDHRIGIFAKRAIQPGEELFFDYRY-----GPTE 751
            ||||..:...|.||.|:|:||...|..|.||.|:|..     |.||
Human  1227 NPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCLGNGRTE 1272

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
E(z)NP_001261682.1 PRC2_HTH_1 151..291 CDD:436286 35/195 (18%)
SANT 452..492 CDD:238096 14/98 (14%)
preSET_CXC 579..610 CDD:408079 7/30 (23%)
SET_EZH2 628..747 CDD:380995 45/120 (38%)
NSD3NP_075447.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 121..157
KIKL. /evidence=ECO:0000269|PubMed:29567837 154..157
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 181..252
PWWP domain; Pfam PF00855 264..324
PWWP_NSD3_rpt1 268..397 CDD:438991
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 344..365
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 406..465 6/22 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 540..696 31/172 (18%)
TNG2 <602..746 CDD:227367 34/169 (20%)
PHD type zinc finger motif 697..738 7/40 (18%)
PHD1_NSD3 703..746 CDD:277119 8/51 (16%)
PHD type zinc finger motif 745..795 12/51 (24%)
PHD2_NSD3 751..797 CDD:277122 12/47 (26%)
PHD3_NSD3 798..850 CDD:277125 10/51 (20%)
PHD type zinc finger motif 858..945 10/87 (11%)
PHD4_NSD3 917..952 CDD:277128 2/34 (6%)
PWWP domain; Pfam PF00855 954..1013 8/58 (14%)
PWWP_NSD3_rpt2 959..1053 CDD:438994 14/104 (13%)
AWS 1104..1142 CDD:465559 12/54 (22%)
SET_NSD3 1144..1285 CDD:380989 47/129 (36%)
SET domain 1149..1255 39/105 (37%)
PHD type zinc finger motif 1317..1364
PHD5_NSD3 1323..1365 CDD:277131
C5HCH 1364..1413 CDD:465605
Blue background indicates that the domain is not in the aligned region.

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