DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(z) and setd7

DIOPT Version :9

Sequence 1:	NP_001261682.1	Gene:	E(z) / 39203	FlyBaseID:	FBgn0000629	Length:	765	Species:	Drosophila melanogaster
Sequence 2:	NP_001002456.1	Gene:	setd7 / 436729	ZFINID:	ZDB-GENE-040718-156	Length:	373	Species:	Danio rerio

Alignment Length:	124	Identity:	39/124 - (31%)
Similarity:	54/124 - (43%)	Gaps:	29/124 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   641 AGWGIFLKEGAQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRK------ 699
            ||.|:|.:..|:.|..::.|.|..|:..|.|.|    |..|.....:|:.|.|:|....
Zfish   226 AGEGLFAQTEAEANTVMAFYNGVRITHTEVDSR----DWSMNGNTISLDEDTVIDVPAPFNMTEN 286

  Fly   700 -----GNKIRFANHSINPNC-YAKVMMVTGDH-RIG----IFAKRAIQPGEELFFDYRY 747
                 |:|   ||||.:||| |.:.:     | |.|    |...||::..|||...|.|
Zfish   287 YCGSLGHK---ANHSFSPNCKYDQYV-----HPRFGQIKCIRTIRAVEKDEELTVAYGY 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(z)	NP_001261682.1	SANT	452..492	CDD:238096
		SET	<471..745	CDD:225491	37/120 (31%)
		SET	631..747	CDD:214614	38/122 (31%)
setd7	NP_001002456.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		MORN 1	36..58
		MORN 2	59..81
		MORN 3	106..128
		S-adenosyl-L-methionine binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00910	226..228		1/1 (100%)
		SET	227..336	CDD:279228	36/120 (30%)
		S-adenosyl-L-methionine binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00910	294..297		2/5 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1079
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900