Protein Alignment E(z) and trx

DIOPT Version :10

• Sequence 1: NP_001261682.1
• Gene: E(z) / 39203
• FlyBaseID: FBgn0000629
• Length: 765
• Species: Drosophila melanogaster
• Sequence 2: NP_476769.1
• Gene: trx / 41737
• FlyBaseID: FBgn0003862
• Length: 3726
• Species: Drosophila melanogaster
• Alignment Length: 850
• Identity: 168/850 - (19%)
• Similarity: 289/850 - (34%)
• Gaps: 254/850 - (29%)

  Fly    83 PSGPQKVPICVINAVTPIPTMYTWAPTQ-QNFMVEDETVLHNIPYMGDEVLDKDGKFIEELIKNY 146
            |...|::|..|:|.|..:.......|.| |...::...::| ||..            ::.::..
  Fly  2938 PQLQQQIPAVVVNQVPKVTISQQRIPAQTQQQQLQQAQMIH-IPQQ------------QQPLQQQ 2989

  Fly   147 DGKVHGDKDPSFMDDAIFVELVHALMRSYSKELEEAAPGTATAIKTETLAKSKQGEDDGVVDVDA 211
            ..:|........:.:|..|: ...:|...:.|.:|.|........:.:.:.|.......||
  Fly  2990 QVQVQPSMPIITLAEAPVVQ-SQFVMEPQALEQQELANRVQHFSTSSSSSSSNCSLPTNVV---- 3049

  Fly   212 DGESPMKLEKTDSKGDLT--------EVEKKETEEPLETEDADVKPDVEEVKDKLPFPAPIIFQA 268
               :||:.:...:....|        .:::::...||..|    .|.|.......|...|||.|.
  Fly  3050 ---NPMQQQAPSTTSSSTTRPTNRVLPMQQRQEPAPLSNE----CPVVSSPTPPKPVEQPIIHQM 3107

  Fly   269 ISAN----FPDKGTAQELKEKYIELTEHQDPERPQECTPNIDGIKAESVSRERTMHSFHTLFCRR 329
            .||:    :..|.|.               |....|....:..: .||:..:.||
  Fly  3108 TSASVSKCYAQKSTL---------------PSPVYEAELKVSSV-LESIVPDVTM---------- 3146

  Fly   330 CFKYDCFLHRH------HVQGLQGHAGPN--------LQKRRYPELKPFAEPCSNSCYMLIDGMK 380
                |..|...      :.:||.....|.        ||:::..:|.   :...|:.|:|
  Fly  3147 ----DAILEEQPVTESIYTEGLYEKNSPGESKTEQLLLQQQQREQLN---QQLVNNGYLL----- 3199

  Fly   381 EKLAADSKTPPIDSCNEASSEDSNDSNSQFSNKDF-----NHENS-------KD------NGLT- 426
            :|.....:....|...|...|:..|.:..||.|..     :||.|       ||      :.||
  Fly  3200 DKHTFQVEPMDTDVYREEDLEEEEDEDDDFSLKMATSACNDHEMSDSEEPAVKDKISKILDNLTN 3264

  Fly   427 ------VNSAAVAEINS------IMAGMMNITSTQCVWT----GADQALYRVLHKVYLKNYCAIA 475
                  :.:|...|:::      ::..::..|:.|...|    ||.:.........|: |..|.|
  Fly  3265 DDCADSIATATTMEVDASAGYQQMVEDVLATTAAQSAPTEEFEGALETAAVEAAATYI-NEMADA 3328

  Fly   476 HNMLTKTCRQVYEF---AQKEDAEFSFEDLRQDFT----------PPRKKKKKQRLWSLH-CRKI 526
            |.:..|..:...|.   .:||:.....::..|...          ||:..::.:::...| ..:|
  Fly  3329 HVLDLKQLQNGVELELRRRKEEQRTVSQEQEQSKAAIVPTAAAPEPPQPIQEPKKMTGPHLLYEI 3393

  Fly   527 QLK-----KDSS--------------SNHVYNYTPCDHPGHPCDM-------------------- 552
            |.:     |.||              :...:..||... |...||
  Fly  3394 QSEDGFTYKSSSITEIWEKVFEAVQVARRAHGLTPLPE-GPLADMGGIQMIGLKTNALKYLIEQL 3457

  Fly   553 ----NCSCIQTQNFCEKFCNCSSDC--------------------------------------QN 575
                .|| ..|..:.::..|.|:..                                      :|
  Fly  3458 PGVEKCS-KYTPKYHKRNGNVSTAANGAHGGNLGGSSASAALSVSGGDSHGLLDYGSDQDELEEN 3521

  Fly   576 RFPGCRCKAQCNT-------------KQCPCYLAVRECDPDLCQACG-------ADQFKLTKITC 620
            .:...||:...|.             ::.|..:.|:..|.:|....|       |.:::..|.|.
  Fly  3522 AYDCARCEPYSNRSEYDMFSWLASRHRKQPIQVFVQPSDNELVPRRGTGSNLPMAMKYRTLKETY 3586

  Fly   621 KNVCVQRGLHKHLLMAPSDIAGWGIFLKEGAQKNEFISEYCGEIISQDEADRRGKVYD-KYMCSF 684
            |:..   |:.:      |.|.|.|::..:..:..|.:.||.||:|.....|:|.:.|| :.:..:
  Fly  3587 KDYV---GVFR------SHIHGRGLYCTKDIEAGEMVIEYAGELIRSTLTDKRERYYDSRGIGCY 3642

  Fly   685 LFNLNNDFVVDATRKGNKIRFANHSINPNCYAKVMMVTGDHRIGIFAKRAIQPGEELFFDYRYGP 749
            :|.::::.|||||.:||..||.||...||||:||:.:.|...|.|||.|.|..||||.:||:: |
  Fly  3643 MFKIDDNLVVDATMRGNAARFINHCCEPNCYSKVVDILGHKHIIIFALRRIVQGEELTYDYKF-P 3706

  Fly   750 TEQLK 754
            .|..|
  Fly  3707 FEDEK 3711

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(z)	NP_001261682.1	PRC2_HTH_1	151..291	CDD:436286	26/151 (17%)
		SANT	452..492	CDD:238096	10/46 (22%)
		preSET_CXC	579..610	CDD:408079	8/50 (16%)
		SET_EZH2	628..747	CDD:380995	46/119 (39%)
trx	NP_476769.1	NR_DBD_like	762..>856	CDD:413390
		PRK13914	<1006..>1224	CDD:237555
		PHD1_KMT2A_like	1268..1344	CDD:276981
		PHD	1346..1390	CDD:214584
		PHD3_KMT2A_like	1423..1479	CDD:276983
		ePHD_KMT2A_like	1737..1841	CDD:277134
		FYRN	1890..1937	CDD:461787
		FYRC	3388..3476	CDD:197781	14/89 (16%)
		SET_KMT2A_2B	3575..3726	CDD:380947	52/146 (36%)