DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment E(z) and Ezh2

DIOPT Version :9

Sequence 1:NP_001261682.1 Gene:E(z) / 39203 FlyBaseID:FBgn0000629 Length:765 Species:Drosophila melanogaster
Sequence 2:XP_006236463.1 Gene:Ezh2 / 312299 RGDID:1595860 Length:751 Species:Rattus norvegicus


Alignment Length:809 Identity:440/809 - (54%)
Similarity:520/809 - (64%) Gaps:113/809 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 STKVPPEWKRRVKSEYIKIRQQKRYKRADEIKEAWIRNWDEHNHNVQDLYCESKVWQAKPYDPPH 67
            |.|.|..|::||||||:::||.||::||||:|..:..|..:.....:.|   ::.|:.:...|.|
  Rat     8 SEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKTMFSSNRQKILERTETL---NQEWKQRRIQPVH 69

  Fly    68 VDC-------VKRAEVTSYNGIPSGPQKVPICVINAVTPIPTMYTWAPTQQNFMVEDETVLHNIP 125
            :..       .:...|||....|:  |.:|:..:|||..:|.||:|:|.||||||||||||||||
  Rat    70 IMTSVSSLRGTRECSVTSDLDFPA--QVIPLKTLNAVASVPIMYSWSPLQQNFMVEDETVLHNIP 132

  Fly   126 YMGDEVLDKDGKFIEELIKNYDGKVHGDKDPSFMDDAIFVELVHALMRSYSKELEEAAPGTATAI 190
            ||||||||:||.||||||||||||||||::..|::|.||||||:||                   
  Rat   133 YMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNAL------------------- 178

  Fly   191 KTETLAKSKQGEDDGVVDVDADGESPMKLEKTDSKGDLTEVEKKETEEPLETEDADVKPDVEEVK 255
                    .|..||   |.|.||:.|            .|.|:|:       :|.|...|.:|..
  Rat   179 --------GQYNDD---DDDDDGDDP------------DEREEKQ-------KDLDDSRDDKETC 213

  Fly   256 DKLPFPAPIIFQAISANFPDKGTAQELKEKYIELTEHQDP-ERPQECTPNIDGIKAESVSRERTM 319
            ....|||..||:|||:.|||||||:||||||.||||.|.| ..|.||||||||..|:||.||:::
  Rat   214 PPRKFPADKIFEAISSMFPDKGTAEELKEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSL 278

  Fly   320 HSFHTLFCRRCFKYDCFLHRHHVQGLQGHAGPNLQKRRYPELKPFAEPCSNSCYMLIDGMKEKLA 384
            ||||||||||||||||||||.  .....||.||..||:..|.....:||...||..::|.||..|
  Rat   279 HSFHTLFCRRCFKYDCFLHRK--CNYSFHATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAA 341

  Fly   385 ADS----KTPP------------------------------IDSCNEASSEDSNDSNSQFSNKDF 415
            |.:    ||||                              .||..||.:|...::|      |.
  Rat   342 ALTAERIKTPPKRPGGRRRGRLPNNSSRPSTPTISVLESKDTDSDREAGTETGGENN------DK 400

  Fly   416 NHENSKDNGLTVNSAAVAEINSIMAGMMNITSTQCV-WTGADQALYRVLHKVYLKNYCAIAHNML 479
            ..|..||. .:.:|.|.:...:.:....||...:.| |:||:.:::|||...|..|:||||..:.
  Rat   401 EEEEKKDE-TSSSSEANSRCQTPIKMKPNIEPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIG 464

  Fly   480 TKTCRQVYEFAQKED---AEFSFEDLRQDFTPPRKKKKKQRLWSLHCRKIQLKKDSSSNHVYNYT 541
            ||||||||||..||.   |....||:.   |||||||:|.|||:.||||||||||.||||||||.
  Rat   465 TKTCRQVYEFRVKESSIIAPVPTEDVD---TPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQ 526

  Fly   542 PCDHPGHPCDMNCSCIQTQNFCEKFCNCSSDCQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCQ 606
            |||||..|||.:|.|:..||||||||.|||:|||||||||||||||||||||||||||||||||.
  Rat   527 PCDHPRQPCDSSCPCVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCL 591

  Fly   607 ACG-ADQFKLTKITCKNVCVQRGLHKHLLMAPSDIAGWGIFLKEGAQKNEFISEYCGEIISQDEA 670
            .|| ||.:....::|||..:|||..||||:||||:||||||:|:..|||||||||||||||||||
  Rat   592 TCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEA 656

  Fly   671 DRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSINPNCYAKVMMVTGDHRIGIFAKRAI 735
            |||||||||||||||||||||||||||||||||||||||:|||||||||||.|||||||||||||
  Rat   657 DRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAI 721

  Fly   736 QPGEELFFDYRYGPTEQLKFVGIEREMEI 764
            |.||||||||||...:.||:|||||||||
  Rat   722 QTGEELFFDYRYSQADALKYVGIEREMEI 750

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
E(z)NP_001261682.1 SANT 452..492 CDD:238096 22/39 (56%)
SET <471..745 CDD:225491 216/277 (78%)
SET 631..747 CDD:214614 106/115 (92%)
Ezh2XP_006236463.1 EZH2_WD-Binding 39..68 CDD:402972 4/31 (13%)
PRC2_HTH_1 158..249 CDD:407952 51/139 (37%)
preSET_CXC 564..595 CDD:408079 28/30 (93%)
SET_EZH2 614..733 CDD:380995 107/118 (91%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 274 1.000 Domainoid score I1706
eggNOG 1 0.900 - - E2759_KOG1079
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H37926
Inparanoid 1 1.050 809 1.000 Inparanoid score I459
OMA 1 1.010 - - QHG49242
OrthoDB 1 1.010 - - D118331at33208
OrthoFinder 1 1.000 - - FOG0002374
OrthoInspector 1 1.000 - - otm45742
orthoMCL 1 0.900 - - OOG6_102137
Panther 1 1.100 - - LDO PTHR45747
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X1072
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1514.840

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