DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment E(z) and Ezh1

DIOPT Version :9

Sequence 1:	NP_001261682.1	Gene:	E(z) / 39203	FlyBaseID:	FBgn0000629	Length:	765	Species:	Drosophila melanogaster
Sequence 2:	NP_001100521.1	Gene:	Ezh1 / 303547	RGDID:	1305028	Length:	747	Species:	Rattus norvegicus

Alignment Length:	800	Identity:	400/800 - (50%)
Similarity:	503/800 - (62%)	Gaps:	101/800 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 PPE------WKRRVKSEYIKIRQQKRYKRADEIKEAWIRNWDEHNHNVQDLYCESKVWQAKPYDP 65
            ||.      |||:|||||:::||.||.:.....|..::.|:.:.....|.|..|.|..:.:|..|
  Rat     6 PPTSKCITYWKRKVKSEYMRLRQLKRLQANMGAKALYVANFAKVQEKTQILNEEWKKLRVQPVQP 70

  Fly    66 -------PHVDCVKRAEVTS-YNGIPSGPQKVPICVINAVTPIPTMYTWAPTQQNFMVEDETVLH 122
                   |.   :|:..:.| :.|..|  |.:.:..:|.|..:|.||:|:|.||||||||||||.
  Rat    71 MKPVSGHPF---LKKCTIESIFPGFDS--QDMLMRSLNTVALVPIMYSWSPLQQNFMVEDETVLC 130

  Fly   123 NIPYMGDEVLDKDGKFIEELIKNYDGKVHGDKD--PS--FMDDAIFVELVHALMRSYSKELEEAA 183
            |||||||||.::|..||||||.||||||||:::  |.  .:.||:|:|||.|| ..||.|.||
  Rat   131 NIPYMGDEVKEEDETFIEELINNYDGKVHGEEEMIPGSVLISDAVFLELVDAL-NQYSDEEEE-- 192

  Fly   184 PGTATAIKTETLAKSKQGEDDGVVDVDADGESPMKLEKTDSKGDLTEVEKKETEEPLETEDADVK 248
                             |.:|     .:||      ::.|||.|| .|.:|.....:|.
  Rat   193 -----------------GHND-----TSDG------KQDDSKEDL-PVTRKRKRHAIEG------ 222

  Fly   249 PDVEEVKDKLPFPAPIIFQAISANFPDKGTAQELKEKYIELTEHQDPER-PQECTPNIDGIKAES 312
               .:...|..||..:||.||::.||:.|...::||:|.||||..||.. |.:|||||||..|:|
  Rat   223 ---NKKSSKKQFPNDMIFSAIASMFPENGVPDDMKERYRELTEMSDPNALPPQCTPNIDGPNAKS 284

  Fly   313 VSRERTMHSFHTLFCRRCFKYDCFLHRHHVQGLQGHAGPNLQKRRYPELKPFAEPCSNSCYMLID 377
            |.||:::|||||||||||||||||||..       ||.||:.||:..|:|...|||...|::.::
  Rat   285 VQREQSLHSFHTLFCRRCFKYDCFLHPF-------HATPNVYKRKNREIKIEPEPCGADCFLWLE 342

  Fly   378 GMKEKLAADS-----------KTPPID-SCNEASSEDSNDSNSQFSNKDFNHE--------NSKD 422
            |.||.....:           :.|.:. ||:..|:....::....|::|..::        ||:.
  Rat   343 GAKEYAMLHNPRSKCSGRRRRRHPVVSASCSNTSASAMAETKEGDSDRDTGNDWASSSSEANSRC 407

  Fly   423 NGLTVNSAAVAEINSIMAGMMNITSTQCVWTGADQALYRVLHKVYLKNYCAIAHNMLTKTCRQVY 487
            ...|...|:.|.....   ::...|....||||:::|:||.|..|..|:|:||..:.||||:||:
  Rat   408 QTPTKQKASPAPPQLC---VVEAPSEPVEWTGAEESLFRVFHGTYFNNFCSIARLLGTKTCKQVF 469

  Fly   488 EFAQKED--AEFSFEDLRQDFTPPRKKKKKQRLWSLHCRKIQLKKDSSSNHVYNYTPCDHPGHPC 550
            :||.||.  .:...::|   ..|.:|||:|.|||:.||||||||||::|..||||.|||||..||
  Rat   470 QFAVKESLILKLPTDEL---MNPSQKKKRKHRLWAAHCRKIQLKKDNNSTQVYNYQPCDHPDRPC 531

  Fly   551 DMNCSCIQTQNFCEKFCNCSSDCQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCQACGA-DQFK 614
            |..|.||.|||||||||.||.||||||||||||.|||||||||||||||||||||..||| :.:.
  Rat   532 DSTCPCIMTQNFCEKFCQCSPDCQNRFPGCRCKTQCNTKQCPCYLAVRECDPDLCLTCGASEHWD 596

  Fly   615 LTKITCKNVCVQRGLHKHLLMAPSDIAGWGIFLKEGAQKNEFISEYCGEIISQDEADRRGKVYDK 679
            ...::|||..:||||.||||:||||:||||.|:||..||||||||||||:|||||||||||||||
  Rat   597 CKVVSCKNCSIQRGLKKHLLLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVYDK 661

  Fly   680 YMCSFLFNLNNDFVVDATRKGNKIRFANHSINPNCYAKVMMVTGDHRIGIFAKRAIQPGEELFFD 744
            ||.|||||||||||||||||||||||||||:||||||||:||.||||||||||||||.|||||||
  Rat   662 YMSSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQAGEELFFD 726

  Fly   745 YRYGPTEQLKFVGIEREMEI 764
            |||...:.||:||||||.::
  Rat   727 YRYSQADALKYVGIERETDV 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(z)	NP_001261682.1	SANT	452..492	CDD:238096	21/39 (54%)
		SET	<471..745	CDD:225491	203/276 (74%)
		SET	631..747	CDD:214614	103/115 (90%)
Ezh1	NP_001100521.1	EZH2_WD-Binding	39..68	CDD:402972	6/28 (21%)
		PRC2_HTH_1	159..262	CDD:407952	43/143 (30%)
		SANT	433..474	CDD:238096	21/40 (53%)
		SET	<463..727	CDD:225491	199/266 (75%)
		SET_EZH1	608..743	CDD:380994	115/134 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	274	1.000	Domainoid score	I1706
eggNOG	1	0.900	-	-		E2759_KOG1079
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	809	1.000	Inparanoid score	I459
OMA	1	1.010	-	-		QHG49242
OrthoDB	1	1.010	-	-		D118331at33208
OrthoFinder	1	1.000	-	-		FOG0002374
OrthoInspector	1	1.000	-	-		otm45742
orthoMCL	1	0.900	-	-		OOG6_102137
Panther	1	1.100	-	-	O	PTHR45747
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1072
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840