DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment E(z) and EZH1

DIOPT Version :9

Sequence 1:NP_001261682.1 Gene:E(z) / 39203 FlyBaseID:FBgn0000629 Length:765 Species:Drosophila melanogaster
Sequence 2:NP_001308008.1 Gene:EZH1 / 2145 HGNCID:3526 Length:753 Species:Homo sapiens


Alignment Length:801 Identity:400/801 - (49%)
Similarity:502/801 - (62%) Gaps:101/801 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 PPE------WKRRVKSEYIKIRQQKRYKRADEIKEAWIRNWDEHNHNVQDLYCESKVWQAKPYDP 65
            ||.      |||:|||||:::||.||.:.....|..::.|:.:.....|.|..|.|..:.:|...
Human    12 PPTSKCITYWKRKVKSEYMRLRQLKRLQANMGAKALYVANFAKVQEKTQILNEEWKKLRVQPVQS 76

  Fly    66 -------PHVDCVKRAEVTS-YNGIPSGPQKVPICVINAVTPIPTMYTWAPTQQNFMVEDETVLH 122
                   |.   :|:..:.| :.|..|  |.:.:..:|.|..:|.||:|:|.||||||||||||.
Human    77 MKPVSGHPF---LKKCTIESIFPGFAS--QHMLMRSLNTVALVPIMYSWSPLQQNFMVEDETVLC 136

  Fly   123 NIPYMGDEVLDKDGKFIEELIKNYDGKVHGDKD--PS--FMDDAIFVELVHALMRSYSKELEEAA 183
            |||||||||.::|..||||||.||||||||:::  |.  .:.||:|:|||.|| ..||.|.||  
Human   137 NIPYMGDEVKEEDETFIEELINNYDGKVHGEEEMIPGSVLISDAVFLELVDAL-NQYSDEEEE-- 198

  Fly   184 PGTATAIKTETLAKSKQGEDDGVVDVDADGESPMKLEKTDSKGDLTEVEKKETEEPLETEDADVK 248
                             |.:|     .:||      ::.|||.|| .|.:|.....:|.      
Human   199 -----------------GHND-----TSDG------KQDDSKEDL-PVTRKRKRHAIEG------ 228

  Fly   249 PDVEEVKDKLPFPAPIIFQAISANFPDKGTAQELKEKYIELTEHQDPER-PQECTPNIDGIKAES 312
               .:...|..||..:||.||::.||:.|...::||:|.||||..||.. |.:|||||||..|:|
Human   229 ---NKKSSKKQFPNDMIFSAIASMFPENGVPDDMKERYRELTEMSDPNALPPQCTPNIDGPNAKS 290

  Fly   313 VSRERTMHSFHTLFCRRCFKYDCFLHRHHVQGLQGHAGPNLQKRRYPELKPFAEPCSNSCYMLID 377
            |.||:::|||||||||||||||||||..       ||.||:.||:..|:|...|||...|::|::
Human   291 VQREQSLHSFHTLFCRRCFKYDCFLHPF-------HATPNVYKRKNKEIKIEPEPCGTDCFLLLE 348

  Fly   378 GMKEKLAADSKTPPID------------SCNEASSEDSNDSNSQFSNKDFNHE--------NSKD 422
            |.||.....:......            ||:.||:....::....|::|..::        ||:.
Human   349 GAKEYAMLHNPRSKCSGRRRRRHHIVSASCSNASASAVAETKEGDSDRDTGNDWASSSSEANSRC 413

  Fly   423 NGLTVNSAAVAEINSIMAGMMNITSTQCVWTGADQALYRVLHKVYLKNYCAIAHNMLTKTCRQVY 487
            ...|...|:.|.....   ::...|....||||:::|:||.|..|..|:|:||..:.||||:||:
Human   414 QTPTKQKASPAPPQLC---VVEAPSEPVEWTGAEESLFRVFHGTYFNNFCSIARLLGTKTCKQVF 475

  Fly   488 EFAQKED--AEFSFEDLRQDFTPPRKKKKKQRLWSLHCRKIQLKKDSSSNHVYNYTPCDHPGHPC 550
            :||.||.  .:...::|   ..|.:|||:|.|||:.||||||||||:||..||||.|||||..||
Human   476 QFAVKESLILKLPTDEL---MNPSQKKKRKHRLWAAHCRKIQLKKDNSSTQVYNYQPCDHPDRPC 537

  Fly   551 DMNCSCIQTQNFCEKFCNCSSDCQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCQACGA-DQFK 614
            |..|.||.|||||||||.|:.||||||||||||.|||||||||||||||||||||..||| :.:.
Human   538 DSTCPCIMTQNFCEKFCQCNPDCQNRFPGCRCKTQCNTKQCPCYLAVRECDPDLCLTCGASEHWD 602

  Fly   615 LTKITCKNVCVQRGLHKHLLMAPSDIAGWGIFLKEGAQKNEFISEYCGEIISQDEADRRGKVYDK 679
            ...::|||..:||||.||||:||||:||||.|:||..||||||||||||:|||||||||||||||
Human   603 CKVVSCKNCSIQRGLKKHLLLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVYDK 667

  Fly   680 YMCSFLFNLNNDFVVDATRKGNKIRFANHSINPNCYAKVMMVTGDHRIGIFAKRAIQPGEELFFD 744
            ||.|||||||||||||||||||||||||||:||||||||:||.||||||||||||||.|||||||
Human   668 YMSSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQAGEELFFD 732

  Fly   745 YRYGPTEQLKFVGIEREMEIV 765
            |||...:.||:||||||.:::
Human   733 YRYSQADALKYVGIERETDVL 753

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
E(z)NP_001261682.1 SANT 452..492 CDD:238096 21/39 (54%)
SET <471..745 CDD:225491 203/276 (74%)
SET 631..747 CDD:214614 103/115 (90%)
EZH1NP_001308008.1 EZH2_WD-Binding 45..73 CDD:288468 6/27 (22%)
SANT 439..480 CDD:238096 21/40 (53%)
SANT 439..480 CDD:197842 21/40 (53%)
SET <469..733 CDD:225491 199/266 (75%)
SET 619..740 CDD:214614 105/120 (88%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 275 1.000 Domainoid score I1765
eggNOG 1 0.900 - - E2759_KOG1079
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 809 1.000 Inparanoid score I489
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG49242
OrthoDB 1 1.010 - - D118331at33208
OrthoFinder 1 1.000 - - FOG0002374
OrthoInspector 1 1.000 - - otm41621
orthoMCL 1 0.900 - - OOG6_102137
Panther 1 1.100 - - O PTHR45747
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1072
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1312.840

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