Protein Alignment E(z) and mes-4

DIOPT Version :10

• Sequence 1: NP_001261682.1
• Gene: E(z) / 39203
• FlyBaseID: FBgn0000629
• Length: 765
• Species: Drosophila melanogaster
• Sequence 2: NP_506333.1
• Gene: mes-4 / 179824
• WormBaseID: WBGene00003222
• Length: 898
• Species: Caenorhabditis elegans
• Alignment Length: 727
• Identity: 153/727 - (21%)
• Similarity: 236/727 - (32%)
• Gaps: 232/727 - (31%)

  Fly   196 AKSKQGEDDGVVDVDADGESPMKLEKTDSK-------GDLT--EVEKKETEEPLETEDAD--VKP 249
            :|......||:|:.:...: |.|.:....:       |..|  ..|.|:.|.|:.|....  :..
 Worm     9 SKENCAPQDGIVEKEGPNK-PFKKKNVKQRNATPQGAGSETSSNAEDKQEEAPILTNAPKDIISM 72

  Fly   250 DVEEVKDKL---------PFP------APIIFQAISANFPDKGTAQ-----ELKEKYIELTEHQD 294
            .::|.|..|         .:|      .|..|.::|...|.:..|:     :...|.:...|.:|
 Worm    73 QIQETKAFLSEYEEFVDTDYPKTTFTHVPRKFLSVSPFTPIEADAEGEFLPDADSKCVICHEEKD 137

  Fly   295 PERPQE---CTPNIDGIKAESVSRERTMHSFHTLFCRRCFKYDCFLHRHHVQG--LQGHAGPNLQ 354
            .....:   |...|:|   |....:|.:.:.....||..|...|.:: ::..|  .|..|....|
 Worm   138 KTGKSDLITCHGYING---EMDDGKRLLGNIPMFPCRSKFHASCMIN-YNSGGFHFQYAARLECQ 198

  Fly   355 KRRYPELKPFAEPCSNSCYMLIDGMKE--------KLAADSKTPPIDSCNEASSEDSNDS----- 406
            .|....|.     |.|||.  :|..|:        :.|...:...:.||..:...|.|.|
 Worm   199 ARLLCPLH-----CCNSCN--LDHHKQSAYVGDIAECALCLRAFHLTSCYPSGGRDLNVSITIGG 256

  Fly   407 ------------------NSQFSNKDFNHENSKDNGLTVNSAAVAEINSIMAGMMNITSTQCVWT 453
                              :.||.||   |:..|:....|..|.|...:.|.|         |...
 Worm   257 KVEKFEMIICPAHYLPGADVQFYNK---HKKRKNAVTVVPKADVTMKSHIKA---------CCVI 309

  Fly   454 GADQALYRVLHKVYLKNYCAIAHNMLTKTCRQV-------------------------------- 486
            |.:::...  ..:..|..|...|:    .||:|
 Worm   310 GCEKSSNS--KTIMCKTCCRSFHS----GCREVETLNGKPIPDDQCESCVCGDPIPQNTLILAKW 368

  Fly   487 -------------YEFAQKEDAEFSFEDLR----QDFTPPRKKKKKQRLWS---------LHCRK 525
                         |::........:||.|.    |...|....|:||.|.|         |....
 Worm   369 TDNSFWLALTLDWYKYPTGNRGNINFERLGYTVVQWLIPQENDKEKQPLMSIVPVSDIARLTKNY 433

  Fly   526 IQLKKDSSSNHVYNYTPCDHPGHPCDMNCSCIQTQNFCEKFCNCSSDCQNRFPGCRCKAQCNTKQ 590
            ..|.|:|:..:::.                        ||:...:.....|.|.. ||......:
 Worm   434 FSLAKNSTLRNLWE------------------------EKYEEQADTALKRCPYV-CKTVFGRLR 473

  Fly   591 CPCYLAVRECDP--------DLCQACGADQFKLTKITC---------------KNVC----VQRG 628
            ...|.   :|:|        ::|...|||  :.||::|               |.||    |..|
 Worm   474 TSVYY---KCEPKLEEYHNNEVCNCEGAD--RCTKLSCQYLADDYECPPSCSKKGVCHNRQVSMG 533

  Fly   629 L-HKHLLMAPSDIAGWGIFLKEGAQKNEFISEYCGEIISQDEADRRGKVYDKYMCS-------FL 685
            : .:.:.:|.:...|:|:|.|...:|:|:|.||.||||.:.|..||   .|....|       ::
 Worm   534 IVSEKIKLAATLCKGYGVFAKGQIEKDEYICEYVGEIIDKAEKKRR---LDSVSISRDFQANHYM 595

  Fly   686 FNLNNDFVVDATRKGNKIRFANHSINPNCYAKVMMV---------TGDHRIGIFAKRAIQPGEEL 741
            ..|:....|||.|.||..|:.|||.:||..:.|..|         ..|.|..|.|.|.|..|:|:
 Worm   596 MELHKGLTVDAARYGNISRYINHSCDPNAASFVTKVFVKKTKEGSLYDTRSYIRAIRTIDDGDEI 660

  Fly   742 FFDYRYGPTEQL 753
            .|.|.....|.|
 Worm   661 TFSYNMNNEENL 672

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(z)	NP_001261682.1	PRC2_HTH_1	151..291	CDD:436286	23/125 (18%)
		SANT	452..492	CDD:238096	8/84 (10%)
		preSET_CXC	579..610	CDD:408079	6/38 (16%)
		SET_EZH2	628..747	CDD:380995	45/135 (33%)
mes-4	NP_506333.1	SET_SETD2-like	538..683	CDD:380929	46/138 (33%)