Protein Alignment E(z) and set-2

DIOPT Version :10

• Sequence 1: NP_001261682.1
• Gene: E(z) / 39203
• FlyBaseID: FBgn0000629
• Length: 765
• Species: Drosophila melanogaster
• Sequence 2: NP_498039.1
• Gene: set-2 / 175662
• WormBaseID: WBGene00004782
• Length: 1510
• Species: Caenorhabditis elegans
• Alignment Length: 650
• Identity: 131/650 - (20%)
• Similarity: 212/650 - (32%)
• Gaps: 206/650 - (31%)

  Fly   173 RSYSKELEEAAPGTATAIKTETLAKSKQGEDDGVVDVDADGESPMKLEKTD---SKGDLTEVEKK 234
            :|..::|..::..::|...|.|...|.:...........|||.|.|..:||   .:....|.|::
 Worm   984 KSRKRKLIMSSDESSTTGSTATSVVSSRQSSLEPQQEKTDGEPPKKKSQTDFISERVSKIEGEER 1048

  Fly   235 ETEEPLETEDADVKPDVEEVKDKLPFPAPIIFQAISANFPDKGTAQELKEKYIELTEHQDPERPQ 299
            ...||:||.                  .|||           |.:..|..|.:    |.:.....
 Worm  1049 PLPEPVETS------------------GPII-----------GDSSYLPYKIV----HWEKAGII 1080

  Fly   300 ECTPNIDGIKAESVSRERTMHSFHTLFCRRCFKYDCFLHRHHVQGLQGHAGPNLQKRRYPELKPF 364
            |.....:.|:|         |.:|......|:.                   .:...|.|:::.|
 Worm  1081 EMNLPANSIRA---------HEYHPFTTEHCYF-------------------GIDDPRQPKIQIF 1117

  Fly   365 -AEPCSNSCYMLIDGMKEKLAADSKTPPIDSCNEA-------------SSEDSNDSNSQFSNKD- 414
             ..||.:.     .|.:......:...|||:..|.             :.:.......|...||
 Worm  1118 DHSPCKSE-----PGSEPLKITPAPWGPIDNVAETGPLIYMDVVTAPKTVQKKQKPRKQVFEKDP 1177

  Fly   415 ---FNHENSKDNG------LTVNSAAVAEINSIMAGMMNITSTQCVWTGADQALYRVLHKVYLKN 470
               :....:|...      .|....:..|...|:....::...:..|
 Worm  1178 YEYYEPPPTKRPAPPPRFKKTFKPRSEEEKKKIIGDCEDLPDLEDQW------------------ 1224

  Fly   471 YCAIAHNMLTKTCRQVYEFAQKEDAEFSFEDLRQD-----FTPPRKKK----------------- 513
            |...|.|.:....:...|...|:...|. |.||.:     ..|.|.||
 Worm  1225 YLRAALNEMQSEVKSADELPWKKMLTFK-EMLRSEDPLLRLNPIRSKKGLPDAFYEDEELDGVIP 1288

  Fly   514 -----KKQRLWSLHCRKIQLKKDSSSNHVYNYTPCDHPGHP----CDMNCSCIQTQNFCEK---- 565
                 .:.|.:    .|:.:|:..|...    .| |:..||    .:.:.:.|:.|:...|
 Worm  1289 VAAGCSRARPY----EKMTMKQKRSLVR----RP-DNESHPTAIFSERDETAIRHQHLASKDMRL 1344

  Fly   566 ----FCNCSSDCQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCQACGADQFKLTKITCKNVCVQ 626
                ......|..|.|                                   ||:.::..:.
 Worm  1345 LQRRLLTSLGDANNDF-----------------------------------FKINQLKFRK---- 1370

  Fly   627 RGLHKHLLMAPSDIAGWGIFLKEGAQKNEFISEYCGEIISQDEADRRGKVYDK--YMCSFLFNLN 689
                |.:..|.|.|.|||::..|....:|.|.||.|:.|....|:.|.|.|::  ...|:||.::
 Worm  1371 ----KMIKFARSRIHGWGLYAMESIAPDEMIVEYIGQTIRSLVAEEREKAYERRGIGSSYLFRID 1431

  Fly   690 NDFVVDATRKGNKIRFANHSINPNCYAKVMMVTGDHRIGIFAKRAIQPGEELFFDYRYGPTEQLK 754
            ...|:|||::||..||.|||..|||||||:.:.|:.||.|:::..|:.|||:.:||:: |.|..|
 Worm  1432 LHHVIDATKRGNFARFINHSCQPNCYAKVLTIEGEKRIVIYSRTIIKKGEEITYDYKF-PIEDDK 1495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(z)	NP_001261682.1	PRC2_HTH_1	151..291	CDD:436286	25/120 (21%)
		SANT	452..492	CDD:238096	5/39 (13%)
		preSET_CXC	579..610	CDD:408079	0/30 (0%)
		SET_EZH2	628..747	CDD:380995	49/120 (41%)
set-2	NP_498039.1	RRM_SF	124..213	CDD:473069
		SET_SETD1	1359..1506	CDD:380946	54/180 (30%)