DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment E(z) and mes-2

DIOPT Version :9

Sequence 1:	NP_001261682.1	Gene:	E(z) / 39203	FlyBaseID:	FBgn0000629	Length:	765	Species:	Drosophila melanogaster
Sequence 2:	NP_496992.3	Gene:	mes-2 / 175096	WormBaseID:	WBGene00003220	Length:	773	Species:	Caenorhabditis elegans

Alignment Length:	860	Identity:	212/860 - (24%)
Similarity:	310/860 - (36%)	Gaps:	287/860 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 EWKRRVKSEYIKIRQQKRYKRADE----IKEAWIRN----------------------------- 40
            |.||.:|..:..|:.....:..||    ||: |:::
Worm    61 ECKRMLKGHFNAIKDDYDIRVKDELDTDIKD-WLKDASSSVNEYRRRLQENLGEGRTIAKFSFKN 124

  Fly    41 ---WDEHNHNVQDLYCESKVWQAKPYDPPHVDCVKRAEVTSYNGIPSGPQKVPICVINAVTPIPT 102
               ::|:::.|.|    |.|...||......|.:|:.             :.|...|......|.
Worm   125 CEKYEENDYKVSD----STVTWIKPDRTEEGDLMKKF-------------RAPCSRIEVGDISPP 172

  Fly   103 MYTWAPTQQNFMVEDETVLHNIPYMGDEVLDKDGKFIEELIKNYDGKVHGDKDP-SFMDDAIFVE 166
            |..|.|.:|:....|:..|.::||.||.:  .||...|.||..:...:||..|. |:::|.|..:
Worm   173 MIYWVPIEQSVATPDQLRLTHMPYFGDGI--DDGNIYEHLIDMFPDGIHGFSDNWSYVNDWILYK 235

  Fly   167 LVHALMRSYSKELEEAAPGTATAIKTETLAKSKQGEDDGVVDVDADGESPMKLEKTDSKGDLTEV 231
            |..|.::.|                        ||..|
Worm   236 LCRAALKDY------------------------QGSPD--------------------------- 249

  Fly   232 EKKETEEPLETEDADVKPDVEEVKDKLPFPAPIIFQAISANFPDKGTAQELKEKYIELTEH---- 292
                                            :.:..:...:|:|.:.:|....:..|.|:
Worm   250 --------------------------------VFYYTLYRLWPNKSSQREFSSAFPVLCENFAEK 282

  Fly   293 -QDPE--RPQECTPNIDGIKAESVSRERTMHSFHTLFCRRCFKYDCFLHRHHVQGLQGHAG---P 351
             .||.  .|.:.|...:|  |::: |..|        |..|..|.|.:|     |.:....   |
Worm   283 GFDPSSLEPWKKTKIAEG--AQNL-RNPT--------CYACLAYTCAIH-----GFKAEIPIEFP 331

  Fly   352 NLQKRRYPELKPF-------AEPCSNSCYMLIDGMKEKLAADSKTPPIDSCNEASSEDSNDSNSQ 409
            |  ...|..:.|.       .:.||.:|:..:. |||             .:|....||.:...:
Worm   332 N--GEFYNAMLPLPNNPENDGKMCSGNCWKSVT-MKE-------------VSEVLVPDSEEILQK 380

  Fly   410 -----FSNKDFNHENSKDNGLTVNSAAVAEINSIMAGMMNITSTQCVWTGADQALYRVLHKVYLK 469
                 |..........:|..|.||                                     :|:.
Worm   381 EVKIYFMKSRIAKMPIEDGALIVN-------------------------------------IYVF 408

  Fly   470 N----YCAIAHNML--------TKTCRQVY----EFAQKEDA----------EFSFED----LRQ 504
            |    :|......:        .::||..|    ..|:...|          ..|.:|    .|:
Worm   409 NTYIPFCEFVKKYVDEDDEESKIRSCRDAYHLMMSMAENVSARRLKMGQPSNRLSIKDRVNNFRR 473

  Fly   505 DFTPPRKKKKKQRLWSLHCRKIQ------------LKKDSSSNH-------VYNYTPCDHPGHPC 550
            :.....|.|:|.|..||..:.::            ..:||..|.       |...|.|.|.| ||
Worm   474 NQLSQEKAKRKLRHDSLRIQALRDGLDAEKLIREDDMRDSQRNSEKVRMTAVTPITACRHAG-PC 537

  Fly   551 DM---NCSCIQTQNFCEKFCNCSSDCQNRFPGCRCKA-QCNTKQCPCYLAVRECDPDLCQACGAD 611
            :.   ||:| :....|...|.|..:|..|||||.|.| ||.||.|.||.|..||:|..|..|..|
Worm   538 NATAENCAC-RENGVCSYMCKCDINCSQRFPGCNCAAGQCYTKACQCYRANWECNPMTCNMCKCD 601

  Fly   612 QFKLTKITCKNVCVQRGLHKHLLMAPSDIAGWGIFLKEGAQKNEFISEYCGEIISQDEADRRGKV 676
            ......|.|:|..:.|.:.|.....||.|||.|:||.|.|:|:|||:||.||.||.|||:|||.:
Worm   602 AIDSNIIKCRNFGMTRMIQKRTYCGPSKIAGNGLFLLEPAEKDEFITEYTGERISDDEAERRGAI 666

  Fly   677 YDKYMCSFLFNLNNDFVVDATRKGNKIRFANH-SINPNCYAKVMMVTGDHRIGIFAKRAIQPGEE 740
            ||:|.||::||:.....:|:.:.||..||||| |.||.|||:.|:|.|:||||.:|||.::..||
Worm   667 YDRYQCSYIFNIETGGAIDSYKIGNLARFANHDSKNPTCYARTMVVAGEHRIGFYAKRRLEISEE 731

  Fly   741 LFFDYRYGPTEQLKF 755
            |.|||.|....|:.|
Worm   732 LTFDYSYSGEHQIAF 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(z)	NP_001261682.1	SANT	452..492	CDD:238096	7/55 (13%)
		SET	<471..745	CDD:225491	119/323 (37%)
		SET	631..747	CDD:214614	64/116 (55%)
mes-2	NP_496992.3	Septum_form	<210..265	CDD:290557	16/137 (12%)
mes-2	NP_496992.3	SET	621..742	CDD:214614	65/120 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	128	1.000	Domainoid score	I3318
eggNOG	1	0.900	-	-		E2759_KOG1079
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	259	1.000	Inparanoid score	I1925
Isobase	1	0.950	-	0	Normalized mean entropy	S2678
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D118331at33208
OrthoFinder	1	1.000	-	-		FOG0002374
OrthoInspector	1	1.000	-	-		oto20192
orthoMCL	1	0.900	-	-		OOG6_102137
Panther	1	1.100	-	-	LDO	PTHR45747
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1072
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.870