DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment E(z) and Ezh1

DIOPT Version :9

Sequence 1:	NP_001261682.1	Gene:	E(z) / 39203	FlyBaseID:	FBgn0000629	Length:	765	Species:	Drosophila melanogaster
Sequence 2:	NP_031996.1	Gene:	Ezh1 / 14055	MGIID:	1097695	Length:	750	Species:	Mus musculus

Alignment Length:	800	Identity:	402/800 - (50%)
Similarity:	505/800 - (63%)	Gaps:	101/800 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 PPE------WKRRVKSEYIKIRQQKRYKRADEIKEAWIRNWDEHNHNVQDLYCESKVWQAKPYDP 65
            ||.      |||:|||||:::||.||.:.....|..::.|:.:.....|.|..|.|..:.:|..|
Mouse     9 PPTSKCITYWKRKVKSEYMRLRQLKRLQANMGAKALYVANFAKVQEKTQILNEEWKKLRVQPVQP 73

  Fly    66 -------PHVDCVKRAEVTS-YNGIPSGPQKVPICVINAVTPIPTMYTWAPTQQNFMVEDETVLH 122
                   |.   :|:..:.| :.|..|  |.:.:..:|.|..:|.||:|:|.||||||||||||.
Mouse    74 MKPVSGHPF---LKKCTIESIFPGFDS--QDMLMRSLNTVALVPIMYSWSPLQQNFMVEDETVLC 133

  Fly   123 NIPYMGDEVLDKDGKFIEELIKNYDGKVHGDKD--PS--FMDDAIFVELVHALMRSYSKELEEAA 183
            |||||||||.::|..||||||.||||||||:::  |.  .:.||:|:|||.|| ..||.|
Mouse   134 NIPYMGDEVKEEDETFIEELINNYDGKVHGEEEMIPGSVLISDAVFLELVDAL-NQYSDE----- 192

  Fly   184 PGTATAIKTETLAKSKQGEDDGVVDVDADGESPMKLEKTDSKGDLTEVEKKETEEPLETEDADVK 248
                              |:||..| .:||      ::.|||.|| .|.:|.....:|.
Mouse   193 ------------------EEDGHND-PSDG------KQDDSKEDL-PVTRKRKRHAIEG------ 225

  Fly   249 PDVEEVKDKLPFPAPIIFQAISANFPDKGTAQELKEKYIELTEHQDPER-PQECTPNIDGIKAES 312
               .:...|..||..:||.||::.||:.|...::||:|.||||..||.. |.:|||||||..|:|
Mouse   226 ---NKKSSKKQFPNDMIFSAIASMFPENGVPDDMKERYRELTEMSDPNALPPQCTPNIDGPNAKS 287

  Fly   313 VSRERTMHSFHTLFCRRCFKYDCFLHRHHVQGLQGHAGPNLQKRRYPELKPFAEPCSNSCYMLID 377
            |.||:::|||||||||||||||||||..       ||.||:.||:..|:|...|||...|::|::
Mouse   288 VQREQSLHSFHTLFCRRCFKYDCFLHPF-------HATPNVYKRKNKEIKIEPEPCGTDCFLLLE 345

  Fly   378 GMKEKLAADS-----------KTPPID-SCNEASSEDSNDSNSQFSNKDFNHE--------NSKD 422
            |.||.....:           :.|.:. ||:.||:....::....|::|..::        ||:.
Mouse   346 GAKEYAMLHNPRSKCSGRRRRRHPVVSASCSNASASAMAETKEGDSDRDTGNDWASSSSEANSRC 410

  Fly   423 NGLTVNSAAVAEINSIMAGMMNITSTQCVWTGADQALYRVLHKVYLKNYCAIAHNMLTKTCRQVY 487
            ...|...|:.|.....   ::...|....||||:::|:||.|..|..|:|:||..:.||||:||:
Mouse   411 QTPTKQKASPAPAQLC---VVEAPSEPVEWTGAEESLFRVFHGTYFNNFCSIARLLGTKTCKQVF 472

  Fly   488 EFAQKED--AEFSFEDLRQDFTPPRKKKKKQRLWSLHCRKIQLKKDSSSNHVYNYTPCDHPGHPC 550
            :||.||.  .:...::|   ..|.:|||:|.|||:.||||||||||::|..||||.|||||..||
Mouse   473 QFAVKESLILKLPTDEL---MNPAQKKKRKHRLWAAHCRKIQLKKDNNSTQVYNYQPCDHPDRPC 534

  Fly   551 DMNCSCIQTQNFCEKFCNCSSDCQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCQACGA-DQFK 614
            |..|.||.|||||||||.||.||||||||||||.|||||||||||||||||||||..||| :.:.
Mouse   535 DSTCPCIMTQNFCEKFCQCSPDCQNRFPGCRCKTQCNTKQCPCYLAVRECDPDLCLTCGASEHWD 599

  Fly   615 LTKITCKNVCVQRGLHKHLLMAPSDIAGWGIFLKEGAQKNEFISEYCGEIISQDEADRRGKVYDK 679
            ...::|||..:||||.||||:||||:||||.|:||..||||||||||||:|||||||||||||||
Mouse   600 CKVVSCKNCSIQRGLKKHLLLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVYDK 664

  Fly   680 YMCSFLFNLNNDFVVDATRKGNKIRFANHSINPNCYAKVMMVTGDHRIGIFAKRAIQPGEELFFD 744
            ||.|||||||||||||||||||||||||||:||||||||:||.||||||||||||||.|||||||
Mouse   665 YMSSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQAGEELFFD 729

  Fly   745 YRYGPTEQLKFVGIEREMEI 764
            |||...:.||:||||||.::
Mouse   730 YRYSQADALKYVGIERETDV 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(z)	NP_001261682.1	SANT	452..492	CDD:238096	21/39 (54%)
		SET	<471..745	CDD:225491	203/276 (74%)
		SET	631..747	CDD:214614	103/115 (90%)
Ezh1	NP_031996.1	EZH2_WD-Binding	42..70	CDD:288468	6/27 (22%)
		SANT	436..477	CDD:238096	21/40 (53%)
		SANT	436..477	CDD:197842	21/40 (53%)
		SET	<466..730	CDD:225491	199/266 (75%)
		SET	616..737	CDD:214614	105/120 (88%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	274	1.000	Domainoid score	I1762
eggNOG	1	0.900	-	-		E2759_KOG1079
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	809	1.000	Inparanoid score	I485
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49242
OrthoDB	1	1.010	-	-		D118331at33208
OrthoFinder	1	1.000	-	-		FOG0002374
OrthoInspector	1	1.000	-	-		otm43667
orthoMCL	1	0.900	-	-		OOG6_102137
Panther	1	1.100	-	-	O	PTHR45747
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1072
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840