DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment E(z) and ezh1

DIOPT Version :9

Sequence 1:	NP_001261682.1	Gene:	E(z) / 39203	FlyBaseID:	FBgn0000629	Length:	765	Species:	Drosophila melanogaster
Sequence 2:	XP_031750333.1	Gene:	ezh1 / 100493532	XenbaseID:	XB-GENE-1010736	Length:	793	Species:	Xenopus tropicalis

Alignment Length:	843	Identity:	391/843 - (46%)
Similarity:	504/843 - (59%)	Gaps:	140/843 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNSTKVPPE---------WKRRVKSEYIKIRQQKRYKRADEIKEAWIRNW---DEHNHNVQDLYC 53
            ::|...||:         ||:||:||||:::|.||::.....:..::.|.   .|..|.:.:.:.
Frog    13 LHSPMEPPDPTYTRTLMCWKKRVRSEYIRLQQLKRFQANTAARMFYVENLTKAQERAHLLNEDWK 77

  Fly    54 ESKVWQAKPYDPP--HVDCVKRAEVTSYNGIPSGPQKVPICVINAVTPIPTMYTWAPTQQNFMVE 116
            :.:|...:...|.  |....|....:|:.|.  ..|.:.:..:|.|..:|.||:|:|.|||||||
Frog    78 KLRVQPIQMMKPTSGHPFLKKSTVESSFPGF--AVQTIFMRSLNTVALVPIMYSWSPLQQNFMVE 140

  Fly   117 DETVLHNIPYMGDEVLDKDGKFIEELIKNYDGKVHGDKD-----------------------PSF 158
            |||||.|||||||||.::|..||||||.||||||||:::                       .||
Frog   141 DETVLCNIPYMGDEVKEEDETFIEELINNYDGKVHGEEELDLKSTMLSSPRLHDRERLFRFGQSF 205

  Fly   159 --------------MDDAIFVELVHALMRSYSKELEEAAPGTATAIKTETLAKSKQGEDDGVVDV 209
                          :|||.|:||:.||:: |:.|.|            :.|:.|.:|
Frog   206 SSGRNSTIKTGSGLLDDASFLELMEALLQ-YTDEEE------------KWLSYSTEG-------- 249

  Fly   210 DADGESPMKLEKTDSKGDLTEVEKKETEEPLETEDADVKPDVEEVKDKLPFPAPIIFQAISANFP 274
                    |.|:...:|.:|...|:..||..:.....:.|:            .:||.||||.||
Frog   250 --------KGEEVKEEGPMTRKRKRIAEEGSKRVCRSLLPN------------DLIFSAISAVFP 294

  Fly   275 DKGTAQELKEKYIELTEHQDPER-PQECTPNIDGIKAESVSRERTMHSFHTLFCRRCFKYDCFLH 338
            ::|..:|:|::|.||||..||.. |.:|||||||..|:||.||:::|||||||||||||||||||
Frog   295 ERGFPEEVKKRYKELTEAYDPNALPPQCTPNIDGPCAKSVQREQSLHSFHTLFCRRCFKYDCFLH 359

  Fly   339 RHHVQGLQGHAGPNLQKRRYPELKPFAEPCSNSCYMLIDGMKE--------------------KL 383
            ..       ||.||:.:||..|:|...|||...|::.::|.||                    .|
Frog   360 PF-------HASPNVYRRRNREIKIETEPCGIHCFLWLEGAKEYAMMNNPRSKCLGRRRRKTTAL 417

  Fly   384 AADSKTPPIDSCNEASSE-----DSNDSNSQFSNKDFNHENSKDNGLTVNSAAVAEINSIMAGMM 443
            ||......:....|..|:     |...|:|:.:::.......:...|:.....|:|
Frog   418 AASGSNSNVMETKEGDSDRDTGNDCASSSSEANSRSQTPTKQRQGSLSGELPDVSE--------- 473

  Fly   444 NITSTQCVWTGADQALYRVLHKVYLKNYCAIAHNMLTKTCRQVYEFAQKEDAEFSFEDLRQDFTP 508
              .|....|:||:::|:||.|..|..|:|:||..|.||||:||::|| ..|:.......::..:.
Frog   474 --PSEPVEWSGAEESLFRVFHGTYFNNFCSIARLMGTKTCKQVFQFA-VTDSLLLKVPAKELMST 535

  Fly   509 PRKKKKKQRLWSLHCRKIQLKKDSSSNHVYNYTPCDHPGHPCDMNCSCIQTQNFCEKFCNCSSDC 573
            .:|||:|.|||:.||||||||||:|:|.||||.|||||.||||..|.||.|||||||||.|:.||
Frog   536 AQKKKRKHRLWAAHCRKIQLKKDNSANQVYNYQPCDHPDHPCDSTCPCIMTQNFCEKFCQCNPDC 600

  Fly   574 QNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCQACGADQFKLTK-ITCKNVCVQRGLHKHLLMAP 637
            ||||||||||.|||||||||||||||||||||..|||.:...:| ::|||..:||||.||||:||
Frog   601 QNRFPGCRCKTQCNTKQCPCYLAVRECDPDLCLTCGASEHWDSKVVSCKNCSIQRGLKKHLLLAP 665

  Fly   638 SDIAGWGIFLKEGAQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNK 702
            ||:||||.|:||..||||||||||||:|||||||||||||||||.||||||||||||||||||||
Frog   666 SDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVYDKYMSSFLFNLNNDFVVDATRKGNK 730

  Fly   703 IRFANHSINPNCYAKVMMVTGDHRIGIFAKRAIQPGEELFFDYRYGPTEQLKFVGIEREMEIV 765
            |||||||::|||||||:||.|||||||||||.||.||||||||||...:.||:||||||.:|:
Frog   731 IRFANHSVHPNCYAKVVMVNGDHRIGIFAKRTIQAGEELFFDYRYSQADALKYVGIERETDII 793

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(z)	NP_001261682.1	SANT	452..492	CDD:238096	21/39 (54%)
		SET	<471..745	CDD:225491	201/274 (73%)
		SET	631..747	CDD:214614	101/115 (88%)
ezh1	XP_031750333.1	EZH2_WD-Binding	58..84	CDD:402972	4/25 (16%)
		PRC2_HTH_1	216..311	CDD:407952	36/135 (27%)
		SANT	479..520	CDD:238096	21/41 (51%)
		preSET_CXC	606..637	CDD:408079	27/30 (90%)
		SET_EZH1	654..789	CDD:380994	113/134 (84%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	277	1.000	Domainoid score	I1697
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	806	1.000	Inparanoid score	I484
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D118331at33208
OrthoFinder	1	1.000	-	-		FOG0002374
OrthoInspector	1	1.000	-	-		otm48839
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1072
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.060