DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hay and XPB2

DIOPT Version :9

Sequence 1:	NP_001137931.1	Gene:	hay / 39202	FlyBaseID:	FBgn0001179	Length:	798	Species:	Drosophila melanogaster
Sequence 2:	NP_568591.1	Gene:	XPB2 / 834138	AraportID:	AT5G41360	Length:	766	Species:	Arabidopsis thaliana

Alignment Length:	820	Identity:	418/820 - (50%)
Similarity:	536/820 - (65%)	Gaps:	92/820 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PPKKSRKDRSGGDKFGKKRRAEDEAFTQLVDDNDSLDATESEGIPGAASKNAETNDEQINTDEYG 67
            |.||.:.......|....:..||     ..||.|. |:.:.||                   |..
plant     9 PTKKMKYGGKDDQKMKNIQNVED-----YYDDADE-DSRDGEG-------------------EEK 48

  Fly    68 AKDYRSQMQLRPDHGNRPLWVAPNGHVFLESFSPVYKHAHDFLIAISEPVCRPEHIHEYKLTAYS 132
            .:|: :.::|:|||||||||...:|.:|||:|||:||.|:||||||:|||||||.:|||.||.:|
plant    49 RRDF-TDLELKPDHGNRPLWACADGKIFLETFSPLYKQAYDFLIAIAEPVCRPESMHEYNLTPHS 112

  Fly   133 LYAAVSVGLQTHDIVEYLKRLSKTSIPEGILEFIRLCTLSYGKVKLVLKHNKYFIESPHPEVLQK 197
            |||||||||:|..|:..|.:||||.:|..|::||...|.:|||||||||.|:||||||.||||::
plant   113 LYAAVSVGLETETIISVLNKLSKTKLPGEIIDFIHASTANYGKVKLVLKKNRYFIESPFPEVLKR 177

  Fly   198 LLKDPVIQKCRLIRSEGEDFIQGTLDGKAITQFGTKLPPGATDKPTPDPAAAAGADGTTAVPEDI 262
            ||.|.||.:.|.   ..|.:..|  ||..|.:...:|..|                     |.::
plant   178 LLSDDVINRARF---TSEPYYGG--DGFTIGKTSGELEAG---------------------PGEL 216

  Fly   263 TDFYEKIDKEEEDEDEANLKTVSFEVAQEKIEVIQKRCI--EIEHPLLAEYDFRNDTNNPDINID 325
            .:..|.....||.|      |.|||:....:|.:::||:  .:.:|:|.|||||||..|||::::
plant   217 LNEAELAAAAEEKE------THSFEIDPALVENVKQRCLPNALNYPMLEEYDFRNDNVNPDLDME 275

  Fly   326 LKPAAVLRPYQEKSLRKMFGNGRARSGVIVLPCGAGKSLVGVTACCTVRKRALVLCNSGVSVEQW 390
            |||.|..||||||||.|||||||||||:||||||||||||||:|...::|..|.|..:.|||:||
plant   276 LKPHAQPRPYQEKSLSKMFGNGRARSGIIVLPCGAGKSLVGVSAAARIKKSCLCLATNAVSVDQW 340

  Fly   391 KQQFKMWSTADDSMICRFTSEAKDKPMG-CGILVTTYSMITHTQKRSWEAEQTMRWLQEQEWGIM 454
            ..|||:|||..|..||||||::|::..| .|::||||:||....|||.|||:.:..::.:|||::
plant   341 AYQFKLWSTIKDDQICRFTSDSKERFRGNAGVVVTTYNMIAFGGKRSEEAEKIIEEMRNREWGLL 405

  Fly   455 VLDEVHTIPAKMFRRVLTIVQSHCKLGLTATLLREDDKIADLNFLIGPKLYEANWLELQKKGYIA 519
            ::||||.:||.|||:|::|.:|||||||||||:|||:||.||||||||||||||||:|.|.|:||
plant   406 LMDEVHVVPAHMFRKVISITKSHCKLGLTATLVREDEKITDLNFLIGPKLYEANWLDLVKGGFIA 470

  Fly   520 RVQCAEVWCPMSPEFYREYLTTKTS-KKMLLYVMNPSKFRSCQFLIKYHE-QRGDKTIVFSDNVF 582
            .||||||||||:.||:.|||..:.| ||..||||||:|||:|:|||::|| |||||.|||:||:|
plant   471 NVQCAEVWCPMTKEFFAEYLKKENSKKKQALYVMNPNKFRACEFLIRFHEQQRGDKIIVFADNLF 535

  Fly   583 ALKHYAIKMNKPFIYGPTSQNERIQILQNFKFNSKVNTIFVSKVADTSFDLPEANVLIQISSHGG 647
            ||..||:|:.||.|||.||..||.:||:.||.:..|||:|:|||.|.|.|:|||||:||||||.|
plant   536 ALTEYAMKLRKPMIYGATSHIERTKILEAFKTSKTVNTVFLSKVGDNSIDIPEANVIIQISSHAG 600

  Fly   648 SRRQEAQRLGRILRAKKGAI-------AEEYNAFFYTLVSQDTMEMSYSRKRQRFLVNQGYSYKV 705
            ||||||||||||||| ||.:       .||||||||:|||.||.||.||.|||:||::||||:||
plant   601 SRRQEAQRLGRILRA-KGKLEDRMAGGKEEYNAFFYSLVSTDTQEMYYSTKRQQFLIDQGYSFKV 664

  Fly   706 ITHLKGMDTDSDLMYGTQEEQGQLLQLVLSASDLDCEDEKLPGEPGYRPSGSGGAV---RRVGGL 767
            ||.|...|..|.|.|.:||||..||..||:|.|      .:.|.........|.|:   |.:|.:
plant   665 ITSLPPPDAGSSLGYHSQEEQLSLLGKVLNAGD------DMVGLEQLEEDTDGKALKTRRSMGSM 723

  Fly   768 SSMSGGDDAIYYEH------------RKKNIGSVHPLFKK 795
            |:|||.:..:|.|:            :.|:....|.:|||
plant   724 SAMSGANGRVYMEYNSGRQKSGNQSKKPKDPTKRHNIFKK 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hay	NP_001137931.1	rad25	70..795	CDD:273168	403/751 (54%)
		Helicase_C_3	86..208	CDD:290354	77/121 (64%)
		ResIII	331..488	CDD:282678	95/157 (61%)
		ERCC3_RAD25_C	512..756	CDD:292820	152/252 (60%)
XPB2	NP_568591.1	rad25	51..763	CDD:273168	403/751 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	285	1.000	Domainoid score	I376
eggNOG	1	0.900	-	-		E1_COG1061
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H96
Inparanoid	1	1.050	750	1.000	Inparanoid score	I109
OMA	1	1.010	-	-		QHG60829
OrthoDB	1	1.010	-	-		D100698at2759
OrthoFinder	1	1.000	-	-		FOG0003639
OrthoInspector	1	1.000	-	-		otm3341
orthoMCL	1	0.900	-	-		OOG6_100822
Panther	1	1.100	-	-	O	PTHR11274
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2506
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840