DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hay and ercc3

DIOPT Version :9

Sequence 1:	NP_001137931.1	Gene:	hay / 39202	FlyBaseID:	FBgn0001179	Length:	798	Species:	Drosophila melanogaster
Sequence 2:	NP_963876.1	Gene:	ercc3 / 324323	ZFINID:	ZDB-GENE-030131-3043	Length:	782	Species:	Danio rerio

Alignment Length:	804	Identity:	550/804 - (68%)
Similarity:	658/804 - (81%)	Gaps:	39/804 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 RKDRSGGDKFGKKRRAEDEAFTQLVDDNDSLDATESEGIPGAASKNAETNDEQINTDEYGAKDYR 72
            |||:|..:|..|||..|||.     :|.:.:.....|.:|.||.|..:.:..::  |||||||||
Zfish     3 RKDKSDREKKSKKRYYEDEE-----EDEEVIGGESQEAVPAAAGKQVDESSTKL--DEYGAKDYR 60

  Fly    73 SQMQLRPDHGNRPLWVAPNGHVFLESFSPVYKHAHDFLIAISEPVCRPEHIHEYKLTAYSLYAAV 137
            .||.|:.||.:|||||||:||:|||:||||||:|.|||:|||||||||.|.||||||||||||||
Zfish    61 LQMLLKNDHSSRPLWVAPDGHIFLEAFSPVYKYAQDFLVAISEPVCRPTHAHEYKLTAYSLYAAV 125

  Fly   138 SVGLQTHDIVEYLKRLSKTSIPEGILEFIRLCTLSYGKVKLVLKHNKYFIESPHPEVLQKLLKDP 202
            ||||||.||:|||::|||||:|:||::||:|||:||||||||||||:||:||..|:|:|:||:|.
Zfish   126 SVGLQTSDIIEYLQKLSKTSVPDGIVQFIKLCTVSYGKVKLVLKHNRYFVESAFPDVIQRLLQDT 190

  Fly   203 VIQKCRLIRSEGE--DFIQGTLDGKAITQFGTKLPPGATDKPTPD---PAAAAGADGT---TAVP 259
            ||:.|||..:|||  :.|..|:..|:           |..|...|   |:::..|||.   |.||
Zfish   191 VIRDCRLRSAEGEETELITETISSKS-----------AISKSQQDNGGPSSSQPADGQRSGTQVP 244

  Fly   260 EDITDFYEKIDKEEEDEDEANLKTVSFEVAQEKIEVIQKRCIEIEHPLLAEYDFRNDTNNPDINI 324
            |||..:||::|||||:|:|.  :|||||:.||.||.:|||||::|:||||||||||||.|||||:
Zfish   245 EDIFSYYEQMDKEEEEEEET--QTVSFEIRQEMIEELQKRCIQLEYPLLAEYDFRNDTVNPDINM 307

  Fly   325 DLKPAAVLRPYQEKSLRKMFGNGRARSGVIVLPCGAGKSLVGVTACCTVRKRALVLCNSGVSVEQ 389
            ||||.||||||||||||||||||||||||||||||||||||||||.||||||.|||.||.|||||
Zfish   308 DLKPTAVLRPYQEKSLRKMFGNGRARSGVIVLPCGAGKSLVGVTAACTVRKRCLVLGNSSVSVEQ 372

  Fly   390 WKQQFKMWSTADDSMICRFTSEAKDKPMGCGILVTTYSMITHTQKRSWEAEQTMRWLQEQEWGIM 454
            ||.|||||||.|||.||||||:|||||:||.:.::||||:.||.|||||||:.|.|::.||||::
Zfish   373 WKAQFKMWSTIDDSQICRFTSDAKDKPIGCSVAISTYSMLGHTTKRSWEAERVMEWMKSQEWGLI 437

  Fly   455 VLDEVHTIPAKMFRRVLTIVQSHCKLGLTATLLREDDKIADLNFLIGPKLYEANWLELQKKGYIA 519
            :||||||||||||||||||||:||||||||||:||||||.|||||||||||||||:|||..||||
Zfish   438 ILDEVHTIPAKMFRRVLTIVQAHCKLGLTATLVREDDKIVDLNFLIGPKLYEANWMELQNNGYIA 502

  Fly   520 RVQCAEVWCPMSPEFYREYLTTKTSKKMLLYVMNPSKFRSCQFLIKYHEQRGDKTIVFSDNVFAL 584
            :||||||||||||||||||:..||.|::|||.|||:|||:|||||::||:|.||.|||:||||||
Zfish   503 KVQCAEVWCPMSPEFYREYVAIKTKKRILLYTMNPNKFRACQFLIRFHERRNDKIIVFADNVFAL 567

  Fly   585 KHYAIKMNKPFIYGPTSQNERIQILQNFKFNSKVNTIFVSKVADTSFDLPEANVLIQISSHGGSR 649
            |.|||::|||:|||||||.||:|||||||.|.|:||||:|||.||||||||||||||||||||||
Zfish   568 KEYAIRLNKPYIYGPTSQGERMQILQNFKHNPKINTIFISKVGDTSFDLPEANVLIQISSHGGSR 632

  Fly   650 RQEAQRLGRILRAKKGAIAEEYNAFFYTLVSQDTMEMSYSRKRQRFLVNQGYSYKVITHLKGMDT 714
            |||||||||:||||||.:||||||:||:||||||.||:||.|||||||:||||:||||.|.||:
Zfish   633 RQEAQRLGRVLRAKKGMVAEEYNAYFYSLVSQDTQEMAYSTKRQRFLVDQGYSFKVITKLAGME- 696

  Fly   715 DSDLMYGTQEEQGQLLQLVLSASDLDCEDEKLPGEPGYRPSGSGGAVRRVGGLSSMSGGDDAIYY 779
            :.|||:.|::||.||||.||:|||||.|:|.:.||.|.:|..|    ||.|.:|||||.|||:|.
Zfish   697 EEDLMFSTRDEQQQLLQKVLAASDLDAEEEVVMGEVGGKPQFS----RRAGTMSSMSGADDALYM 757

  Fly   780 EHR-----KKNIG-SVHPLFKKFR 797
            |::     |.::| ::|||||:||
Zfish   758 EYQMPRGSKASVGKNIHPLFKRFR 781

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hay	NP_001137931.1	rad25	70..795	CDD:273168	524/738 (71%)
		Helicase_C_3	86..208	CDD:290354	92/121 (76%)
		ResIII	331..488	CDD:282678	129/156 (83%)
		ERCC3_RAD25_C	512..756	CDD:292820	183/243 (75%)
ercc3	NP_963876.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..47		17/48 (35%)
		Nuclear localization signal. /evidence=ECO:0000255	6..17		4/10 (40%)
		rad25	58..779	CDD:273168	524/738 (71%)
		Helicase_C_3	74..196	CDD:290354	92/121 (76%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	211..242		9/41 (22%)
		ResIII	314..471	CDD:282678	129/156 (83%)
		DEVH box	440..443		2/2 (100%)
		ERCC3_RAD25_C	495..733	CDD:292820	181/238 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574847
Domainoid	1	1.000	374	1.000	Domainoid score	I838
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H96
Inparanoid	1	1.050	1103	1.000	Inparanoid score	I225
OMA	1	1.010	-	-		QHG60829
OrthoDB	1	1.010	-	-		D100698at2759
OrthoFinder	1	1.000	-	-		FOG0003639
OrthoInspector	1	1.000	-	-		oto38953
orthoMCL	1	0.900	-	-		OOG6_100822
Panther	1	1.100	-	-	LDO	PTHR11274
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R402
SonicParanoid	1	1.000	-	-		X2506
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.900