DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hay and ptr8

DIOPT Version :9

Sequence 1:	NP_001137931.1	Gene:	hay / 39202	FlyBaseID:	FBgn0001179	Length:	798	Species:	Drosophila melanogaster
Sequence 2:	NP_593474.1	Gene:	ptr8 / 2542174	PomBaseID:	SPAC17A5.06	Length:	804	Species:	Schizosaccharomyces pombe

Alignment Length:	822	Identity:	422/822 - (51%)
Similarity:	547/822 - (66%)	Gaps:	83/822 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 DRSGGDKFGKKRRAEDEAFTQLVDDNDSLDATESEGIPGAASKNAETNDEQINTDE--------- 65
            |.|..|.:|:             :|:||........|....:|...|.    |::|
pombe    23 DYSDVDNYGE-------------EDDDSYKPAPRIRINNNKTKAQTTT----NSNEARQSGISAM 70

  Fly    66 YGAKDYRSQMQLRPDHGNRPLWVAP-NGHVFLESFSPVYKHAHDFLIAISEPVCRPEHIHEYKLT 129
            :|..|:.:.:.|:.||..||||:.| :|.:.||:|||:.:.|.|||:.|||||.||..||||::|
pombe    71 FGQNDFSNLLGLKLDHTARPLWINPIDGRIILEAFSPLAEQAIDFLVTISEPVSRPAFIHEYRIT 135

  Fly   130 AYSLYAAVSVGLQTHDIVEYLKRLSKTSIPEGILEFIRLCTLSYGKVKLVLKHNKYFIESPHPEV 194
            ||||||||||||:|.||:..|.|||||.||..|::|||.||:||||||||||.|:|||||....|
pombe   136 AYSLYAAVSVGLKTEDIIAVLDRLSKTPIPPSIVDFIRACTVSYGKVKLVLKKNRYFIESGDASV 200

  Fly   195 LQKLLKDPVIQKCRL-----------IRSEGEDFIQGTLDGKAITQFGTKLPPGATDKPTPDP-- 246
            |:.||:||||...|:           .:...||.::   |.|.||...:|   ...:|.:.|.
pombe   201 LRLLLRDPVIGPLRIDYSTQSSKQKSSKPSNEDNVE---DKKDITNDSSK---ETAEKSSSDELF 259

  Fly   247 AAAAGADGTTAVPEDITDFYEKIDKEEEDEDEANLKTVSFEVAQEKIEVIQKRCIEIEHPLLAEY 311
            :|..|                 :.:||:|||..:|    ||:....:|.|:|||.||::|||.||
pombe   260 SAVVG-----------------LQEEEDDEDAVHL----FEIKHSSVETIKKRCAEIDYPLLEEY 303

  Fly   312 DFRNDTNNPDINIDLKPAAVLRPYQEKSLRKMFGNGRARSGVIVLPCGAGKSLVGVTACCTVRKR 376
            |||||..|||:.|||||:..:||||||||.|||||||||||:|||||||||:|||:||.||::|.
pombe   304 DFRNDNINPDLPIDLKPSTQIRPYQEKSLSKMFGNGRARSGIIVLPCGAGKTLVGITAACTIKKS 368

  Fly   377 ALVLCNSGVSVEQWKQQFKMWSTADDSMICRFTSEAKDK-PMGCGILVTTYSMITHTQKRSWEAE 440
            .:|||.|.|||.||:|||..||......|..||::.|:: ....|::|:||||:.:|:.||::::
pombe   369 VIVLCTSSVSVMQWRQQFLQWSNIKPDHIAVFTADHKERFHSEAGVVVSTYSMVANTRNRSYDSQ 433

  Fly   441 QTMRWLQEQEWGIMVLDEVHTIPAKMFRRVLTIVQSHCKLGLTATLLREDDKIADLNFLIGPKLY 505
            :.|.:|..:|||.::|||||.:||.|||||:|.:.:|.||||||||:||||||.|||||||||:|
pombe   434 KMMDFLTGREWGFILLDEVHVVPAAMFRRVVTTIAAHTKLGLTATLVREDDKIDDLNFLIGPKMY 498

  Fly   506 EANWLELQKKGYIARVQCAEVWCPMSPEFYREYLTTKTSKKMLLYVMNPSKFRSCQFLIKYHEQR 570
            ||||::|.:||:||:||||||||.|:.|||.|||...:.|:||||:|||.||::|||||.|||:|
pombe   499 EANWMDLAQKGHIAKVQCAEVWCAMTTEFYNEYLRENSRKRMLLYIMNPKKFQACQFLIDYHEKR 563

  Fly   571 GDKTIVFSDNVFALKHYAIKMNKPFIYGPTSQNERIQILQNFKFNSKVNTIFVSKVADTSFDLPE 635
            |||.|||||||:||:.||||:.|.||||.|.|.||::||:||::|..|||||:|||.|||.||||
pombe   564 GDKIIVFSDNVYALRAYAIKLGKYFIYGGTPQQERMRILENFQYNELVNTIFLSKVGDTSIDLPE 628

  Fly   636 ANVLIQISSHGGSRRQEAQRLGRILRAKKGAIAEEYNAFFYTLVSQDTMEMSYSRKRQRFLVNQG 700
            |..|||||||.|||||||||||||||||: ...|.:|||||:|||:||.||.||.|||.||::||
pombe   629 ATCLIQISSHYGSRRQEAQRLGRILRAKR-RNDEGFNAFFYSLVSKDTQEMYYSSKRQAFLIDQG 692

  Fly   701 YSYKVITHLKGMDTDSDLMYGTQEEQGQLLQLVL----SASDL-DCEDEKLPGEPGYRPSGSGGA 760
            |::||||:||||:...:|.|.::.|:.:|||.||    .|:|| |.||.........|....  |
pombe   693 YAFKVITNLKGMENLPNLAYASKAERLELLQEVLLQNEEAADLDDGEDTSFGSRSLSRAPAK--A 755

  Fly   761 VRRVGGLSSMSGGDDAIYYEHR-------KKNIGSVHPLFKK 795
            .|..|.||:::|.|:..|.|:.       ||:....|.||:|
pombe   756 KRSSGSLSTLAGADNMAYVEYNKSANKQLKKDSKEHHALFRK 797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hay	NP_001137931.1	rad25	70..795	CDD:273168	408/751 (54%)
		Helicase_C_3	86..208	CDD:290354	78/122 (64%)
		ResIII	331..488	CDD:282678	90/157 (57%)
		ERCC3_RAD25_C	512..756	CDD:292820	155/248 (63%)
ptr8	NP_593474.1	rad25	75..797	CDD:273168	408/751 (54%)
		Helicase_C_3	91..214	CDD:290354	78/122 (64%)
		ResIII	323..481	CDD:282678	90/157 (57%)
		ERCC3_RAD25_C	505..740	CDD:292820	152/235 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	295	1.000	Domainoid score	I265
eggNOG	1	0.900	-	-		E1_COG1061
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H96
Inparanoid	1	1.050	765	1.000	Inparanoid score	I80
OMA	1	1.010	-	-		QHG60829
OrthoFinder	1	1.000	-	-		FOG0003639
OrthoInspector	1	1.000	-	-		oto101935
orthoMCL	1	0.900	-	-		OOG6_100822
Panther	1	1.100	-	-	LDO	PTHR11274
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R402
SonicParanoid	1	1.000	-	-		X2506
TreeFam	1	0.960	-	-
	14	13.860