DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hay and Ercc3

DIOPT Version :9

Sequence 1:	NP_001137931.1	Gene:	hay / 39202	FlyBaseID:	FBgn0001179	Length:	798	Species:	Drosophila melanogaster
Sequence 2:	NP_598419.1	Gene:	Ercc3 / 13872	MGIID:	95414	Length:	783	Species:	Mus musculus

Alignment Length:	805	Identity:	553/805 - (68%)
Similarity:	656/805 - (81%)	Gaps:	31/805 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGPPKKSRKDRSGGDKFGKKRRAEDEAFTQLVDDNDSLDATES-EGIPGAASKNAETNDEQINTD 64
            ||  |:.|.||.  .|..|||:.|:|.     :|.|.:...|| |.:|.||.|..:.:..::  |
Mouse     1 MG--KRDRVDRD--KKKSKKRQYEEEE-----EDEDDIPGNESQEAVPSAAGKQVDESSTKV--D 54

  Fly    65 EYGAKDYRSQMQLRPDHGNRPLWVAPNGHVFLESFSPVYKHAHDFLIAISEPVCRPEHIHEYKLT 129
            ||||||||.||.|:.||.:|||||||:||:|||:||||||:|.|||:||:||||||.|:||||||
Mouse    55 EYGAKDYRQQMPLKGDHTSRPLWVAPDGHIFLEAFSPVYKYAQDFLVAIAEPVCRPTHVHEYKLT 119

  Fly   130 AYSLYAAVSVGLQTHDIVEYLKRLSKTSIPEGILEFIRLCTLSYGKVKLVLKHNKYFIESPHPEV 194
            ||||||||||||||.||.|||::||||.:|:||::||:|||:||||||||||||:||:||.||:|
Mouse   120 AYSLYAAVSVGLQTSDITEYLRKLSKTGVPDGIIQFIKLCTVSYGKVKLVLKHNRYFVESSHPDV 184

  Fly   195 LQKLLKDPVIQKCRLIRSEGE--DFIQGTLDGK-AITQFGTKLPPGATDKPTPDPAAAAGADGTT 256
            :|.||:||||::|||..:|||  :.|..|...| ||::...:...|      |..:....|..|:
Mouse   185 IQHLLQDPVIRECRLRNAEGEATELITETFTSKSAISKTAAEGSGG------PSTSQGVDAQATS 243

  Fly   257 AVPEDITDFYEKIDKEEEDEDEANLKTVSFEVAQEKIEVIQKRCIEIEHPLLAEYDFRNDTNNPD 321
            .:|:|:.||||::||:||:|:|.  :||||||.||.||.:|||||.:|:||||||||||||.|||
Mouse   244 DIPKDLFDFYEQMDKDEEEEEET--QTVSFEVKQEMIEELQKRCICLEYPLLAEYDFRNDTLNPD 306

  Fly   322 INIDLKPAAVLRPYQEKSLRKMFGNGRARSGVIVLPCGAGKSLVGVTACCTVRKRALVLCNSGVS 386
            |||||||.||||||||||||||||||||||||||||||||||||||||.||||||.|||.||.||
Mouse   307 INIDLKPTAVLRPYQEKSLRKMFGNGRARSGVIVLPCGAGKSLVGVTAACTVRKRCLVLGNSAVS 371

  Fly   387 VEQWKQQFKMWSTADDSMICRFTSEAKDKPMGCGILVTTYSMITHTQKRSWEAEQTMRWLQEQEW 451
            |||||.|||||||.|||.||||||:|||||:||.:.::||||:.||.|||||||:.|.||:.|||
Mouse   372 VEQWKAQFKMWSTIDDSQICRFTSDAKDKPIGCSVAISTYSMLGHTTKRSWEAERVMEWLKTQEW 436

  Fly   452 GIMVLDEVHTIPAKMFRRVLTIVQSHCKLGLTATLLREDDKIADLNFLIGPKLYEANWLELQKKG 516
            |:|:|||||||||:||||||||||:||||||||||:||||||.|||||||||||||||:|||..|
Mouse   437 GLMILDEVHTIPARMFRRVLTIVQAHCKLGLTATLVREDDKIVDLNFLIGPKLYEANWMELQNNG 501

  Fly   517 YIARVQCAEVWCPMSPEFYREYLTTKTSKKMLLYVMNPSKFRSCQFLIKYHEQRGDKTIVFSDNV 581
            |||:||||||||||||||||||:..||.|::|||.|||:|||:||||||:||:|.||.|||:|||
Mouse   502 YIAKVQCAEVWCPMSPEFYREYVAIKTKKRILLYTMNPNKFRACQFLIKFHERRNDKIIVFADNV 566

  Fly   582 FALKHYAIKMNKPFIYGPTSQNERIQILQNFKFNSKVNTIFVSKVADTSFDLPEANVLIQISSHG 646
            ||||.|||::|||:|||||||.||:|||||||.|.|:||||:|||.|||||||||||||||||||
Mouse   567 FALKEYAIRLNKPYIYGPTSQGERMQILQNFKHNPKINTIFISKVGDTSFDLPEANVLIQISSHG 631

  Fly   647 GSRRQEAQRLGRILRAKKGAIAEEYNAFFYTLVSQDTMEMSYSRKRQRFLVNQGYSYKVITHLKG 711
            ||||||||||||:||||||.:|||||||||:||||||.||:||.|||||||:||||:||||.|.|
Mouse   632 GSRRQEAQRLGRVLRAKKGMVAEEYNAFFYSLVSQDTQEMAYSTKRQRFLVDQGYSFKVITKLAG 696

  Fly   712 MDTDSDLMYGTQEEQGQLLQLVLSASDLDCEDEKLPGEPGYRPSGSGGAVRRVGGLSSMSGGDDA 776
            |: :.:|.:.|:|||.||||.||:|:|||.|:|.:.||.|.|   ||.|.||.|.:||:||.||.
Mouse   697 ME-EEELAFSTKEEQQQLLQKVLAATDLDAEEEVVAGEFGSR---SGQASRRCGTMSSLSGADDT 757

  Fly   777 IYYEHR----KKNIGSVHPLFKKFR 797
            :|.|:.    |.:...||||||:||
Mouse   758 VYMEYHSSRSKASSKHVHPLFKRFR 782

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hay	NP_001137931.1	rad25	70..795	CDD:273168	523/731 (72%)
		Helicase_C_3	86..208	CDD:290354	92/121 (76%)
		ResIII	331..488	CDD:282678	130/156 (83%)
		ERCC3_RAD25_C	512..756	CDD:292820	183/243 (75%)
Ercc3	NP_598419.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52		21/59 (36%)
		Nuclear localization signal. /evidence=ECO:0000255	6..18		6/13 (46%)
		rad25	60..780	CDD:273168	523/731 (72%)
		Helicase_C_3	76..198	CDD:290354	92/121 (76%)
		ResIII	316..473	CDD:282678	130/156 (83%)
		DEVH box	442..445		2/2 (100%)
		ERCC3_RAD25_C	497..740	CDD:292820	184/246 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831985
Domainoid	1	1.000	372	1.000	Domainoid score	I890
eggNOG	1	0.900	-	-		E1_COG1061
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H96
Inparanoid	1	1.050	1101	1.000	Inparanoid score	I234
Isobase	1	0.950	-	0	Normalized mean entropy	S335
OMA	1	1.010	-	-		QHG60829
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003639
OrthoInspector	1	1.000	-	-		oto94896
orthoMCL	1	0.900	-	-		OOG6_100822
Panther	1	1.100	-	-	LDO	PTHR11274
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R402
SonicParanoid	1	1.000	-	-		X2506
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.740