DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hay and ercc3

DIOPT Version :9

Sequence 1:	NP_001137931.1	Gene:	hay / 39202	FlyBaseID:	FBgn0001179	Length:	798	Species:	Drosophila melanogaster
Sequence 2:	NP_001123812.1	Gene:	ercc3 / 100170563	XenbaseID:	XB-GENE-1009820	Length:	786	Species:	Xenopus tropicalis

Alignment Length:	806	Identity:	553/806 - (68%)
Similarity:	650/806 - (80%)	Gaps:	30/806 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGPPKKSRKDRSGGDKFGKKRRAEDEAFTQLVDDNDSLDATE-SEGIPGAASKNAETNDEQINTD 64
            ||  |:.:.||....|| |:|..|:|.     ::.:.:...| .|.:|.||.|  :.::.....|
Frog     1 MG--KRDKADRGDKKKF-KRRHYEEED-----EEEEEVPGGEYQEAVPSAAGK--QVDEAGTKQD 55

  Fly    65 EYGAKDYRSQMQLRPDHGNRPLWVAPNGHVFLESFSPVYKHAHDFLIAISEPVCRPEHIHEYKLT 129
            ||||||||.||.|:.||.:|||||||:||:|||:||||||:|.|||:|||||||||.|.||||||
Frog    56 EYGAKDYRLQMPLKMDHSSRPLWVAPDGHIFLEAFSPVYKYAQDFLVAISEPVCRPSHTHEYKLT 120

  Fly   130 AYSLYAAVSVGLQTHDIVEYLKRLSKTSIPEGILEFIRLCTLSYGKVKLVLKHNKYFIESPHPEV 194
            ||||||||||||||.||||||::||||.:||||::||:|||:||||||||||||:||:||.||||
Frog   121 AYSLYAAVSVGLQTSDIVEYLQKLSKTGVPEGIVQFIKLCTVSYGKVKLVLKHNRYFVESTHPEV 185

  Fly   195 LQKLLKDPVIQKCRLIRSEGE--DFIQGT-LDGKAITQFGTKLPPGATDKPTPDPAAAAGADGTT 256
            :|:||:|.||:.|||..:||.  |.|..| |...||::.......|.:....|:     |.|.|.
Frog   186 IQELLQDSVIRGCRLRDAEGNETDLITETFLSKSAISKASETAASGPSTSQVPE-----GQDKTN 245

  Fly   257 AVPEDITDFYEKIDKEEEDEDEANLKTVSFEVAQEKIEVIQKRCIEIEHPLLAEYDFRNDTNNPD 321
             ||.|:.:|||::|||||:|:|.  :||||||.|:.||.:||:||.:|:||||||||||||.|||
Frog   246 -VPADLFEFYEQMDKEEEEEEET--QTVSFEVKQDNIEELQKQCIHLEYPLLAEYDFRNDTMNPD 307

  Fly   322 INIDLKPAAVLRPYQEKSLRKMFGNGRARSGVIVLPCGAGKSLVGVTACCTVRKRALVLCNSGVS 386
            |||||||.||||||||||||||||||||||||||||||||||||||||.||||||.|||.||.||
Frog   308 INIDLKPTAVLRPYQEKSLRKMFGNGRARSGVIVLPCGAGKSLVGVTAACTVRKRCLVLGNSAVS 372

  Fly   387 VEQWKQQFKMWSTADDSMICRFTSEAKDKPMGCGILVTTYSMITHTQKRSWEAEQTMRWLQEQEW 451
            |||||.|||||||.|||.||||||:|||||:||.|.::||||:.||.|||||||:.|.||:.|||
Frog   373 VEQWKAQFKMWSTIDDSQICRFTSDAKDKPIGCSIAISTYSMLGHTTKRSWEAERVMEWLKSQEW 437

  Fly   452 GIMVLDEVHTIPAKMFRRVLTIVQSHCKLGLTATLLREDDKIADLNFLIGPKLYEANWLELQKKG 516
            |:|:||||||||||||||||||||:||||||||||:||||||.|||||||||||||||:|||..|
Frog   438 GLMILDEVHTIPAKMFRRVLTIVQAHCKLGLTATLVREDDKIVDLNFLIGPKLYEANWMELQNNG 502

  Fly   517 YIARVQCAEVWCPMSPEFYREYLTTKTSKKMLLYVMNPSKFRSCQFLIKYHEQRGDKTIVFSDNV 581
            |||:||||||||||||||||||:..||.|::|||.|||:|||:||||||:||:|.||.|||:|||
Frog   503 YIAKVQCAEVWCPMSPEFYREYVAIKTKKRILLYTMNPNKFRACQFLIKFHERRNDKIIVFADNV 567

  Fly   582 FALKHYAIKMNKPFIYGPTSQNERIQILQNFKFNSKVNTIFVSKVADTSFDLPEANVLIQISSHG 646
            ||||.|||:::||:|||||||.||:.||||||.|.|:||||:|||.|||||||||||||||||||
Frog   568 FALKEYAIRLSKPYIYGPTSQGERMHILQNFKHNPKINTIFISKVGDTSFDLPEANVLIQISSHG 632

  Fly   647 GSRRQEAQRLGRILRAKKGAIAEEYNAFFYTLVSQDTMEMSYSRKRQRFLVNQGYSYKVITHLKG 711
            ||||||||||||:||||||.:|||||||||:||||||.||:||.|||||||:||||:||||.|.|
Frog   633 GSRRQEAQRLGRVLRAKKGMVAEEYNAFFYSLVSQDTQEMAYSTKRQRFLVDQGYSFKVITKLAG 697

  Fly   712 MDTDSDLMYGTQEEQGQLLQLVLSASDLDCEDEKLPGEPGYRPSGSGGAVRRVGGLSSMSGGDDA 776
            |: :..|.:..:|:|.||||.||:|||||.|:|.:.||.|.|.:..  ..||||.:|||||.|||
Frog   698 ME-EEHLAFSNKEDQQQLLQKVLAASDLDAEEEVVVGEFGSRSTMQ--VSRRVGTMSSMSGADDA 759

  Fly   777 IYYE-HRKKNIGS----VHPLFKKFR 797
            :|.| |..:|.|:    ||||||:||
Frog   760 VYMEYHTSRNRGASNKHVHPLFKRFR 785

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hay	NP_001137931.1	rad25	70..795	CDD:273168	527/732 (72%)
		Helicase_C_3	86..208	CDD:290354	95/121 (79%)
		ResIII	331..488	CDD:282678	132/156 (85%)
		ERCC3_RAD25_C	512..756	CDD:292820	180/243 (74%)
ercc3	NP_001123812.1	rad25	61..783	CDD:273168	527/732 (72%)
		Helicase_C_3	77..199	CDD:290354	95/121 (79%)
		ResIII	317..474	CDD:282678	132/156 (85%)
		ERCC3_RAD25_C	498..739	CDD:292820	179/241 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	277	1.000	Domainoid score	I1700
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H96
Inparanoid	1	1.050	818	1.000	Inparanoid score	I464
OMA	1	1.010	-	-		QHG60829
OrthoDB	1	1.010	-	-		D100698at2759
OrthoFinder	1	1.000	-	-		FOG0003639
OrthoInspector	1	1.000	-	-		oto105098
Panther	1	1.100	-	-	LDO	PTHR11274
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R402
SonicParanoid	1	1.000	-	-		X2506
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110