DRSC/TRiP Functional Genomics Resources

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Protein Alignment ARHGAP1 and RhoGAP19D

DIOPT Version :10

Sequence 1:NP_004299.1 Gene:ARHGAP1 / 392 HGNCID:673 Length:439 Species:Homo sapiens
Sequence 2:NP_001285496.1 Gene:RhoGAP19D / 33048 FlyBaseID:FBgn0031118 Length:2206 Species:Drosophila melanogaster


Alignment Length:154 Identity:37/154 - (24%)
Similarity:79/154 - (51%) Gaps:17/154 - (11%)


- Green bases have known domain annotations that are detailed below.


Human   259 IPIVLRETVAYLQAHALTTEGIFRRSANTQVVREVQQKYNMGLPVDF--------DQYNELHLPA 315
            :|.::......::...|...||:|...|...:.|:.:..|   ..||        |::.::::.:
  Fly  1238 VPHLVEVCTNIVETKGLGVVGIYRIPGNKAAISELSELVN---TKDFQFESCASDDRWEDVNVVS 1299

Human   316 VILKTFLRELPEPLLTFDLYPHVVGFLNIDES---QRVPATLQVLQTLPEENYQVLRFLTAFLVQ 377
            .:||.|:|.||:.|:....|   :.|:..|:.   :|:....:::::||...|:.::.|...|.:
  Fly  1300 SLLKLFIRSLPDALMPASYY---INFIEADKKFGLERIVLLREIVESLPRHPYETMKHLIRHLCR 1361

Human   378 ISAHSDQNKMTNTNLAVVFGPNLL 401
            :|.:.|.|:|...|||::|||:::
  Fly  1362 VSGNCDVNRMEPKNLAIIFGPSII 1385

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ARHGAP1NP_004299.1 SH3-binding 228..238
RhoGAP-p50rhoGAP 239..431 CDD:239869 37/154 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 28..52
CRAL_TRIO_2 82..216 CDD:463965
RhoGAP19DNP_001285496.1 PDZ_canonical 52..204 CDD:483948
RhoGAP_ARHGAP21 1221..1417 CDD:239860 37/154 (24%)
Blue background indicates that the domain is not in the aligned region.

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