Protein Alignment ARHGAP1 and RhoGAP18B

DIOPT Version :10

• Sequence 1: NP_004299.1
• Gene: ARHGAP1 / 392
• HGNCID: 673
• Length: 439
• Species: Homo sapiens
• Sequence 2: NP_573352.2
• Gene: RhoGAP18B / 32898
• FlyBaseID: FBgn0261461
• Length: 1317
• Species: Drosophila melanogaster
• Alignment Length: 447
• Identity: 101/447 - (22%)
• Similarity: 165/447 - (36%)
• Gaps: 123/447 - (27%)

Human    42 PKSDDSKSS-------------SPELVTHLK--WDDPYYDIARHQIVEVAG--------DDKYGR 83
            |:||||..|             :|.:...||  |:         :.|..||        ..:.||
  Fly   935 PRSDDSGCSCEAEDSYNHQHNPTPAIPKPLKEEWE---------RAVLAAGAVAGKRGVAPRTGR 990

Human    84 KIIVFSACRMPPSHQLDHSKLLGYLKHTLD---------------------QYVESD-------- 119
            |:.|.|..|:     |....:|.: :.||.                     |.::.|
  Fly   991 KLRVRSNARL-----LLTDSVLAW-RETLQDVNCCEDEEDMIVPVTDILRAQQIQEDNEVQQTQQ 1049

Human   120 YTLLYLHHGLTSDNKPSLSWLRDAYREFDRKYKKNIKALYIVHPTMFIKTLLILFKPLISFKFGQ 184
            .|:|..:..::..|      |.|...|.|:|..||                    :..:.|....
  Fly  1050 STILQRYKSVSIGN------LLDLPGEDDKKSIKN--------------------RMRMKFAVNS 1088

Human   185 KIFYVNYLSELSEHVKLEQLGIPRQVLKYDDFLKSTQKSPATAPKPMPPRPPLPNQQFGVSLQHL 249
            .:|.:| .|..||.....:.|      :.:......||.|.                |...|..|
  Fly  1089 NVFRIN-RSPKSEKKSRSRRG------QVNSLYLDEQKYPL----------------FAAPLSAL 1130

Human   250 QEKNPEQEPIPIVLRETVAYL-QAHALTTEGIFRRSANTQVVREVQQKYNMGLPVDFDQYNELHL 313
            :....:...:|..:.:..||: |...:..:|::|.|.|..:|.|:::|........:.:.:::|.
  Fly  1131 ELNMTDHPNVPRFVVDVCAYIEQPECIEQDGLYRASGNKVLVDELRKKLTHVYDPRWLKTDDIHT 1195

Human   314 PAVILKTFLRELPEPLLTFDLYPHVVGFLNIDESQRVPATLQVLQTLPEENYQVLRFLTAFLVQI 378
            ...:.|.|.|||..||:|.:.|..:...||.|.:  :.........:||.|...||||...|.::
  Fly  1196 LTSLHKQFFRELTSPLITQEAYERLGRSLNDDAA--IERMSLAFDDMPEPNRSTLRFLIRHLTRV 1258

Human   379 SAHSDQNKMTNTNLAVVFGPNLLWAKDAAITLKAINPINTFTKFLLDHQGELFPSPD 435
            :|.|..|:|.:||||:|:||.||.|....:.   |..:|...|.|:::...:| .||
  Fly  1259 AAASASNRMPSTNLAIVWGPCLLSANQIQLD---IGRMNMLAKVLIENYDRIF-HPD 1311

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ARHGAP1	NP_004299.1	SH3-binding	228..238		0/9 (0%)
		RhoGAP-p50rhoGAP	239..431	CDD:239869	53/192 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	28..52		6/22 (27%)
		CRAL_TRIO_2	82..216	CDD:463965	29/162 (18%)
RhoGAP18B	NP_573352.2	RhoGAP	1141..1285	CDD:459875	46/145 (32%)