Protein Alignment ARHGAP1 and RhoGAP5A

DIOPT Version :10

• Sequence 1: NP_004299.1
• Gene: ARHGAP1 / 392
• HGNCID: 673
• Length: 439
• Species: Homo sapiens
• Sequence 2: NP_727007.1
• Gene: RhoGAP5A / 31473
• FlyBaseID: FBgn0029778
• Length: 494
• Species: Drosophila melanogaster
• Alignment Length: 221
• Identity: 61/221 - (27%)
• Similarity: 100/221 - (45%)
• Gaps: 19/221 - (8%)

Human   187 FYVNYL-SELSEHVKLEQLGIPRQVLKYDDFLKSTQKSPATAPKPMPPRPPLPNQQFGVSLQHLQ 250
            |..|:| ...::.||.|..|          |:..::.|....||.:|....: ...||..|..:.
  Fly   257 FCANFLWGFTAQGVKCEACG----------FVAHSKCSELVPPKCVPDLKRI-RGVFGTDLTTMV 310

Human   251 EKNPEQEPIPIVLRETVAYLQAHALTTEGIFRRSANTQVVREVQQKYNM-GLPVDFDQ--YNELH 312
            :..|..: ||.|:|..|..::|..:..|||:|.|.....:..::...:. |...|..:  |..::
  Fly   311 QLEPHHQ-IPFVVRRCVEEVEARGMLQEGIYRVSGFADEIEALKLALDREGEKTDMSETAYGNVN 374

Human   313 LPAVILKTFLRELPEPLLTFDLYPH--VVGFLNIDESQRVPATLQVLQTLPEENYQVLRFLTAFL 375
            :.|..||.:||.||.||:||..||.  ..|.......|| ....:.::.||..::..|:::...|
  Fly   375 VIAGTLKLYLRLLPVPLITFQAYPSFMAAGRTGKQAEQR-QLMAEAVRRLPPAHHSCLQYMLEHL 438

Human   376 VQISAHSDQNKMTNTNLAVVFGPNLL 401
            .::::|...|||...|||.||.|.|:
  Fly   439 KRVASHYAVNKMNEHNLATVFAPTLI 464

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ARHGAP1	NP_004299.1	SH3-binding	228..238		3/9 (33%)
		RhoGAP-p50rhoGAP	239..431	CDD:239869	49/168 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	28..52
		CRAL_TRIO_2	82..216	CDD:463965	7/29 (24%)
RhoGAP5A	NP_727007.1	SH2_a2chimerin_b2chimerin	75..166	CDD:198215
		C1_CHN	241..293	CDD:410356	11/45 (24%)
		RhoGAP_chimaerin	302..491	CDD:239837	49/165 (30%)