DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rbfox1 and Rbfox2

DIOPT Version :9

Sequence 1:	NP_001246707.1	Gene:	Rbfox1 / 39198	FlyBaseID:	FBgn0052062	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	XP_006521631.1	Gene:	Rbfox2 / 93686	MGIID:	1933973	Length:	464	Species:	Mus musculus

Alignment Length:	439	Identity:	146/439 - (33%)
Similarity:	186/439 - (42%)	Gaps:	99/439 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   279 GGGGGTPSSPLSNSPSSATASQAGGCGLTLNGSAT-----------EGSMSGDTSPVASGEPL-- 330
            |.|...|...||..|.:..|:..|    ..|...|           :|:....|:|.|..:|.
Mouse    35 GAGADGPEPGLSKRPRTEEAADGG----MQNEPLTPGYHGFPARDGQGNQEPTTTPDAMVQPFTT 95

  Fly   331 LQTPPAHQQQQQQQQPLLCSSPTSMQSSGTSVT--GSSIASGTLAATSSSGV-GLLPTTGLDSIA 392
            :..||..|.....:..:..:...:.|:|..::|  ||:...|..::.|.|.. |.|..|
Mouse    96 IPFPPPPQNGIPTEYGVPHTQDYAGQTSEHNLTLYGSTQPHGEQSSNSPSNQNGSLTQT------ 154

  Fly   393 NGGAPTGCAVVPASTSQVIAHLNAAAAAASGIVSPSANVATSLSSALVPAQSVAAVAAASLDAKS 457
            .|||.|                                          ..|.....::.:.::||
Mouse   155 EGGAQT------------------------------------------DGQQSQTQSSENSESKS 177

  Fly   458 QPKRLHVSNIPFRFRDPDLRAMFGQFGTILDVEIIFNERGSKGFGFVTFANSNDAERARERLHGT 522
            .|||||||||||||||||||.||||||.|||||||||||||||||||||.||.||:||||:||||
Mouse   178 TPKRLHVSNIPFRFRDPDLRQMFGQFGKILDVEIIFNERGSKGFGFVTFENSADADRAREKLHGT 242

  Fly   523 VVEGRKIEVNNATARVQTKK--VTAVPN------VVLTKDGAIPAPALVCVQWPEAAVAAAMRGV 579
            ||||||||||||||||.|.|  ||...|      ||    ||:..|.|......:|.|:......
Mouse   243 VVEGRKIEVNNATARVMTNKKMVTPYANGWKLSPVV----GAVYGPELYAASSFQADVSLGNEAA 303

  Fly   580 AIQRGHVGVVGATPYHH----PHHPHHHPALLAASAAAAQQQQQRQLAAAAV----ATAAVAQQQ 636
            ....|..|:....|...    |..|:...|..||:...|..:.:.:....||    .||..|...
Mouse   304 VPLSGRGGINTYIPLISLPLVPGFPYPTAATTAAAFRGAHLRGRGRTVYGAVRAVPPTAIPAYPG 368

  Fly   637 QQQQQAVVQQQQQQVAAA-----------AQQQHQQQQQQQQQAVQQQQ 674
            ...|:.::..:..|:.:|           ....|....|.|.|.:|..|
Mouse   369 IVLQEPIISAKIPQIESANCFRSNRVDMQPTDMHSLLLQPQPQLLQPLQ 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rbfox1	NP_001246707.1	RRM	<454..>542	CDD:223796	77/87 (89%)
Rbfox1	NP_001246707.1	RRM_FOX1_like	460..535	CDD:240853	68/74 (92%)
Rbfox2	XP_006521631.1	half-pint	<164..>330	CDD:130706	94/169 (56%)
		RRM_FOX1_like	180..255	CDD:240853	68/74 (92%)
		Fox-1_C	324..>380	CDD:372095	12/55 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830964
Domainoid	1	1.000	127	1.000	Domainoid score	I5353
eggNOG	1	0.900	-	-		E1_KOG0125
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001186
OrthoInspector	1	1.000	-	-		otm42644
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR15597
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2530
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.830