DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rbfox1 and Cstf2

DIOPT Version :9

Sequence 1:	NP_001246707.1	Gene:	Rbfox1 / 39198	FlyBaseID:	FBgn0052062	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	XP_038955991.1	Gene:	Cstf2 / 683927	RGDID:	1596566	Length:	624	Species:	Rattus norvegicus

Alignment Length:	469	Identity:	87/469 - (18%)
Similarity:	151/469 - (32%)	Gaps:	126/469 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   460 KRLHVSNIPFRFRDPDLRAMFGQFGTILDVEIIFN-ERGS-KGFGFVTFANSNDAERARERLHGT 522
            :.:.|.|||:...:..|:.:|.:.|.::...:::: |.|. ||:||..:.:...|..|...|:|.
  Rat    16 RSVFVGNIPYEATEEQLKDIFSEVGPVVSFRLVYDRETGKPKGYGFCEYQDQETALSAMRNLNGR 80

  Fly   523 VVEGRKIEVNNATARVQTKKVTAVPNVVLTKDGAIPAPALVCVQWPEAAVAAAMRGVAIQRGHVG 587
            ...||.:.|:||.:....:::         |.....||.:
  Rat    81 EFSGRALRVDNAASEKNKEEL---------KSLGTGAPVI------------------------- 111

  Fly   588 VVGATPYHHPHHPHHHPALLAASAAAAQQQQQRQLAAAAVATAAVAQQQQQQQQAVVQQQQQQVA 652
               .:||.....|...|..::.:.|:...:|..:|              .:|.:..||...|:.
  Rat   112 ---ESPYGESISPEDAPESISKAVASLPPEQMFEL--------------MKQMKLCVQNSPQEA- 158

  Fly   653 AAAQQQHQQQQQQQQQAVQQQQAVQQ--------QQQHQQQQ-----QQQQQQQHAAVAAAAAAA 704
                :....|..|...|:.|.|.|.:        :..|:|..     ....|..|.|...:....
  Rat   159 ----RNMLLQNPQLAYALLQAQVVMRIVDPEIALKILHRQTNIPTLISGNPQPVHVAGPGSGPNV 219

  Fly   705 S----HPHMHAAHAHAHAHALG--PQLAQLQAVAVPTAASNAAALQQSLAAAIQNPSGNPNAAAA 763
            |    :|....|.:.:..|..|  |.:.......||      |.:|  :|||:..|  .|.:.|.
  Rat   220 SMNQQNPQAPQAQSLSGMHVNGAPPMMQASMPGGVP------APVQ--MAAAVAGP--GPGSLAP 274

  Fly   764 AAAYAAR----------LSAATGATQSPQTAAAAAAAASMAASANAANNAAALHGFAPVYYDPFL 818
            |....|:          :....|..|......|..|:.............|::.|..     |.|
  Rat   275 AGVMQAQVGMQGAGPVPMERGQGTLQHSPVGPAGPASIERVQGQRTWMIWASVRGST-----PSL 334

  Fly   819 AAAASADPNLRFQAAKPVTEVPAAQPAAILNRRTVTTLNSNPHTINRIPVPQNVLATAP------ 877
            ..:...|         .:..:|...|.|.:.|..:..         .:|.|:.:|..||
  Rat   335 LVSGGLD---------GIAVLPMQDPRAAMQRGALPA---------NVPTPRGLLGDAPNDPRGG 381

  Fly   878 LLKTPLSQAQQQAY 891
            .|.|...:.:.:||
  Rat   382 TLMTVTGEVEPRAY 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rbfox1	NP_001246707.1	RRM	<454..>542	CDD:223796	22/83 (27%)
Rbfox1	NP_001246707.1	RRM_FOX1_like	460..535	CDD:240853	21/76 (28%)
Cstf2	XP_038955991.1	RRM_CSTF2_CSTF2T	10..94	CDD:410072	22/77 (29%)
		CSTF2_hinge	112..191	CDD:405077	17/97 (18%)
		PRK14718	<444..>501	CDD:173181
		CSTF_C	580..620	CDD:405061
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910