Protein Alignment Rbfox1 and rbfox2

DIOPT Version :10

• Sequence 1: NP_001246707.1
• Gene: Rbfox1 / 39198
• FlyBaseID: FBgn0052062
• Length: 962
• Species: Drosophila melanogaster
• Sequence 2: XP_012816391.1
• Gene: rbfox2 / 493447
• XenbaseID: XB-GENE-489991
• Length: 445
• Species: Xenopus tropicalis
• Alignment Length: 712
• Identity: 185/712 - (25%)
• Similarity: 226/712 - (31%)
• Gaps: 320/712 - (44%)

  Fly   275 GGGGGGGGGT------PSSPLSNSPSSATASQAGGCGLTLNGSATEGSMSGDTSPVASGEPLLQT 333
            |..|..|.|.      |.....::..|...|||      ....|.:.| .|:..|.|:.:.::|.
 Frog    30 GSSGASGAGVKRQRVEPEQQEPDNTMSVPVSQA------YQAYAAQNS-QGNQEPTATPDTMVQP 87

  Fly   334 ------PPAHQQ-------QQQQQQPLLCSSPTSMQSSGTSVTGSSIASGTLAATSSSGVGLLPT 385
                  ||..|.       .|..|:....|:...:...|   .|.|.|..:..|||::......|
 Frog    88 FAAIPFPPPPQNGLSTDYGSQHTQEYATQSTEHGIPLYG---GGQSHAEHSTPATSTANASSTQT 149

  Fly   386 TGLDSIANGGAPTGCAVVPASTSQVIAHLNAAAAAASGIVSPSANVATSLSSALVPAQSVAAVAA 450
            .|                               :...|..|.:.|...|
 Frog   150 DG-------------------------------SQTEGQQSQTQNSENS---------------- 167

  Fly   451 ASLDAKSQPKRLHVSNIPFRFRDPDLRAMFGQFGTILDVEIIFNERGSKGFGFVTFANSNDAERA 515
               ::|..|||||||||||||||||||.||||||.|||||||||||||||||||||..|.||:||
 Frog   168 ---ESKPTPKRLHVSNIPFRFRDPDLRQMFGQFGKILDVEIIFNERGSKGFGFVTFETSADADRA 229

  Fly   516 RERLHGTVVEGRKIEVNNATARVQTKKVTAVPNVVLTKDGAIPAPALVCVQWPEAAVAAAMRGVA 580
            ||:||.|||||||||||||||||.|.|.:..|    ..:|           |..:.|..|:.|
 Frog   230 REKLHSTVVEGRKIEVNNATARVMTNKKSVTP----YGNG-----------WKLSPVVGAVYG-- 277

  Fly   581 IQRGHVGVVGATPYHHPHHPHHHPALLAASAAAAQQQQQRQLAAAAVATAAVAQQQQQQQQAVVQ 645
                                   |.|.||:...
 Frog   278 -----------------------PELYAAAPGL-------------------------------- 287

  Fly   646 QQQQQVAAAAQQQHQQQQQQQQQAVQQQQAVQQQQQHQQQQQQQQQQQHAAVAAAAAAASHPHMH 710
              |..|:.|.:                                             |....|...
 Frog   288 --QADVSLATE---------------------------------------------AGVPLPGPR 305

  Fly   711 AAHAHAHAHALGPQLAQLQAVAVPTAASNAAALQQSLAAAIQNPSGNPNAAAAAAAYAARLSAAT 775
            ..:.:.             .:.:|                     |.|...|||||
 Frog   306 GVNTYI-------------PLIIP---------------------GFPYPTAAAAA--------- 327

  Fly   776 GATQSPQTAAAAAAAASMAASANAANNAAALHGFAPVYYDPFLAAAASADPNLRFQAAKPVTEVP 840
                   |.|||...|.:.........|.                           .|.|.|.:|
 Frog   328 -------TTAAAFRGAHLRGRGRTVYGAV---------------------------RAVPPTAIP 358

  Fly   841 AAQPAAILNRRTVTTLNSNPHTINRIPVPQNVLATAPLLKTPLSQAQQQAYATAATTYTAVAARA 905
             ..|..:|..                          |:|...|.|.   .||....|..|.||.|
 Frog   359 -TYPGLVLQE--------------------------PILNPKLPQG---GYAAYRYTQPATAATA 393

  Fly   906 AYGAAAAAAAQPALAGYATVAGYAREY-ADPYLGHGIGPVPGYG----ATMYRGGFNRFTPY 962
            |..|||||||      |:.  ||.|.| ||||  |.:.|...||    |::||||::||.||
 Frog   394 ATAAAAAAAA------YSD--GYGRVYTADPY--HALAPATSYGVGAVASLYRGGYSRFAPY 445

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rbfox1	NP_001246707.1	RRM_FOX1_like	460..535	CDD:409841	66/74 (89%)
rbfox2	XP_012816391.1	ELAV_HUD_SF	<53..245	CDD:273741	93/251 (37%)
		RRM_FOX1_like	174..249	CDD:409841	66/74 (89%)
		Fox-1_C	315..417	CDD:463568	46/203 (23%)