DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rbfox1 and rbfox1l

DIOPT Version :9

Sequence 1:	NP_001246707.1	Gene:	Rbfox1 / 39198	FlyBaseID:	FBgn0052062	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	NP_999940.1	Gene:	rbfox1l / 407613	ZFINID:	ZDB-GENE-040923-2	Length:	382	Species:	Danio rerio

Alignment Length:	705	Identity:	178/705 - (25%)
Similarity:	210/705 - (29%)	Gaps:	383/705 - (54%)

- Green bases have known domain annotations that are detailed below.

  Fly   300 QAGGC--GLTLNGSATE-GSMSGDTS------PVASGEPLLQTPPA------------------- 336
            |...|  |:....:|.| |..:||.|      |..|..|..|.||.
Zfish    19 QTASCYPGIVQGAAAQEAGPGNGDPSLPQVYAPPPSYPPPGQAPPTPAARLPPLDFSAAHPNSEY 83

  Fly   337 --HQQQQQQQQPLLCSSPTSMQSSGT-SVTGSSIASGTLAATSSSGVGLLPTTGLDSIANGGAPT 398
              |.|.:..|.|         |..|| |:|.|:........||.
Zfish    84 ADHHQLRVYQGP---------QHDGTESITASNTDDSLAPVTSD--------------------- 118

  Fly   399 GCAVVPASTSQVIAHLNAAAAAASGIVSPSANVATSLSSALVPAQSVAAVAAASLD----AKSQP 459
                 |.|       |:.:.|:.||                         ||...|    .|:||
Zfish   119 -----PQS-------LSVSVASGSG-------------------------AAGGSDEEGGGKAQP 146

  Fly   460 KRLHVSNIPFRFRDPDLRAMFGQFGTILDVEIIFNERGSKGFGFVTFANSNDAERARERLHGTVV 524
            ||||||||||||||||||.||||||.|||||||||||||||||||||.::.:|:||||:|:||:|
Zfish   147 KRLHVSNIPFRFRDPDLRQMFGQFGKILDVEIIFNERGSKGFGFVTFESAVEADRAREKLNGTIV 211

  Fly   525 EGRKIEVNNATARVQTKKVTAVPNVVLTKDGAIPAPALVCVQWPEAAVAAAMRGVAIQRGHVGVV 589
            ||||||||||||||.|||    |.          .|.:....|....|..||
Zfish   212 EGRKIEVNNATARVVTKK----PQ----------TPLVNAAGWKINPVMGAM------------- 249

  Fly   590 GATPYHHPHHPHHHPALLAASAAAAQQQQQRQLAAAAVATAAVAQQQQQQQQAVVQQQQQQVAAA 654
                        :.|.|.
Zfish   250 ------------YAPELY----------------------------------------------- 255

  Fly   655 AQQQHQQQQQQQQQAVQQQQAVQQQQQHQQQQQQQQQQQHAAVAAAAAAASHPHMHAAHAHAHAH 719
                                                           ..||.|:
Zfish   256 -----------------------------------------------TVASFPY----------- 262

  Fly   720 ALGPQLAQLQAVAVPTAASNAAALQQSLAAAIQNPSGNPNAAAAAAAYAARLSAATGATQSPQTA 784
                      .|..||.|...:.|:                ....|.|              .|.
Zfish   263 ----------PVPTPTLAYRGSGLR----------------GRGRAVY--------------NTI 287

  Fly   785 AAAAAAASMAASANAANNAAALHGFAPVYYDPFLAAAASADPNLRFQAAKPVTEVPAAQPAAILN 849
            .:|||||:.||              .|.|            |.:.:|......||....||
Zfish   288 RSAAAAATPAA--------------VPAY------------PGVVYQEGLYGAEVYGGYPA---- 322

  Fly   850 RRTVTTLNSNPHTINRIPVPQNVLATAPLLKTPLSQAQQQAYATAATTYTAVAARAAYGAAAAAA 914
                                                           ||     |.|..|:|||.
Zfish   323 -----------------------------------------------TY-----RVAQSASAAAT 335

  Fly   915 AQPALAGYATVAGYAREYA---DPYLGHGIGPVPGYG----ATMYRGGFNRFTPY 962
            |.     |:.  ||.|.||   ||| .|.:||...||    |::||||:||||||
Zfish   336 AT-----YSD--GYGRVYATATDPY-HHSVGPTTTYGVGTMASLYRGGYNRFTPY 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rbfox1	NP_001246707.1	RRM	<454..>542	CDD:223796	73/91 (80%)
Rbfox1	NP_001246707.1	RRM_FOX1_like	460..535	CDD:240853	63/74 (85%)
rbfox1l	NP_999940.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	34..79		11/44 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	94..148		21/120 (18%)
		RRM	<143..>237	CDD:223796	76/107 (71%)
		RRM_FOX1_like	147..222	CDD:240853	63/74 (85%)
		Fox-1_C	257..353	CDD:289199	42/235 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573881
Domainoid	1	1.000	125	1.000	Domainoid score	I5404
eggNOG	1	0.900	-	-		E1_KOG0125
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001186
OrthoInspector	1	1.000	-	-		otm24241
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR15597
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.800