Protein Alignment Rbfox1 and rbfox2

DIOPT Version :10

• Sequence 1: NP_001246707.1
• Gene: Rbfox1 / 39198
• FlyBaseID: FBgn0052062
• Length: 962
• Species: Drosophila melanogaster
• Sequence 2: NP_999911.2
• Gene: rbfox2 / 406569
• ZFINID: ZDB-GENE-040426-2464
• Length: 425
• Species: Danio rerio
• Alignment Length: 696
• Identity: 185/696 - (26%)
• Similarity: 217/696 - (31%)
• Gaps: 322/696 - (46%)

  Fly   277 GGGGGGGTPSSPLSNSPSSATASQAGGCGLTLNGSATEGSMSGDTSPVASGEPLLQTPPAHQQQQ 341
            |....|.:..:....:....|...|.|         ::.||.|:...|.   |....||....|
Zfish    42 GAAAAGDSTGAECKRARMDGTEDIAQG---------SQDSMCGEEGAVV---PFFPPPPPPPPQ- 93

  Fly   342 QQQQPLLCSSPTSMQSSGTSVTGSSIASGTLAATSSSGVGLLPTTGLDSIANGGAPTGCAVVPAS 406
                            :|.|:..||...|..:..||||
Zfish    94 ----------------NGLSLEFSSGGGGGSSVYSSSG--------------------------- 115

  Fly   407 TSQVIAHLNAAAAAASGIVSPSANVATSLSSA-------LVPAQSVAAVAAASLDAKSQPKRLHV 464
                  ...|.|..:||..:||    |.||.|       ||...:..|:...|.:||..||||||
Zfish   116 ------QTEAVAGTSSGASNPS----TQLSDASPQPDNQLVLVSNAVAIREDSSEAKGTPKRLHV 170

  Fly   465 SNIPFRFRDPDLRAMFGQFGTILDVEIIFNERGSKGFGFVTFANSNDAERARERLHGTVVEGRKI 529
            |||||||||||||.||||||.|||||||||||||||||||||.:|.|||:||||||||:||||||
Zfish   171 SNIPFRFRDPDLRQMFGQFGKILDVEIIFNERGSKGFGFVTFESSGDAEKARERLHGTIVEGRKI 235

  Fly   530 EVNNATARVQTKKVTAVPNVVLTKDGAIPAPALVCVQWPEAAVAAAMRGVAIQRGHVGVVGATPY 594
            |||||||||.|.|....|.........:|...     |..:.:..||.|...            |
Zfish   236 EVNNATARVMTNKKMVSPYANGDSLSTLPYAG-----WKLSPMMGAMYGPEF------------Y 283

  Fly   595 HHPHHPHHHPALLAASAAAAQQQQQRQLAAAAVATAAVAQQQQQQQQAVVQQQQQQVAAAAQQQH 659
            ..|..|
Zfish   284 AVPGFP----------------------------------------------------------- 289

  Fly   660 QQQQQQQQQAVQQQQAVQQQQQHQQQQQQQQQQQHAAVAAAAAAASHPHMHAAHAHAHAHALGPQ 724
                                              :...||||||||   ..|:...||....|..
Zfish   290 ----------------------------------YPTTAAAAAAAS---TAASFRGAHLRGRGRP 317

  Fly   725 LAQLQAVAVPTAASNA---AALQQSLAAAIQNPSGNPNAAAAAAAYAARLSAATGATQSPQTAAA 786
            :......|||..|..|   ...|.....|.:..||          |.|.......|..|| ||||
Zfish   318 VYGAVRAAVPQPAIPAYPGVVYQDGFYGATELYSG----------YTAYRYTQPTAVASP-TAAA 371

  Fly   787 AAAAASMAASANAANNAAALHGFAPVYYDPFLAAAASADPNLRFQAAKPVTEVPAAQPAAILNRR 851
            |||||:.:.|            :..||         :|||
Zfish   372 AAAAAAYSDS------------YGRVY---------AADP------------------------- 390

  Fly   852 TVTTLNSNPHTINRIPVPQNVLATAPLLKTPLSQAQQQAYATAATTYTAVAARAAYGAAAAAAAQ 916
                                                   ||.|..| .|.||.||||..|.
Zfish   391 ---------------------------------------YAAALAT-PAAAAAAAYGVGAM---- 411

  Fly   917 PALAGYATVAGYAREYADPYLGHGIGPVPGYGATMYRGGFNRFTPY 962
                                            ||:||||::||:||
Zfish   412 --------------------------------ATLYRGGYSRFSPY 425

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rbfox1	NP_001246707.1	RRM_FOX1_like	460..535	CDD:409841	67/74 (91%)
rbfox2	NP_999911.2	RRM_FOX1_like	166..241	CDD:409841	67/74 (91%)
		Fox-1_C	285..386	CDD:463568	38/219 (17%)