DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rbfox1 and Rbfox1

DIOPT Version :9

Sequence 1:	NP_001246707.1	Gene:	Rbfox1 / 39198	FlyBaseID:	FBgn0052062	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	XP_038941736.1	Gene:	Rbfox1 / 302920	RGDID:	1311210	Length:	564	Species:	Rattus norvegicus

Alignment Length:	459	Identity:	150/459 - (32%)
Similarity:	184/459 - (40%)	Gaps:	150/459 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   282 GGTPSSPLSNSPSSATASQAGGCG----LTLNGSATEGSMSGDTSPVASGEPLLQTPPAHQQQQQ 342
            |.|...| :.......|:|.||.|    |:|..|..|..             :|.:||..|.::.
  Rat    47 GATTPRP-ARDERDELATQTGGEGRSEQLSLPPSLVESQ-------------VLVSPPVDQAEET 97

  Fly   343 QQQP------------------LLCSSPTS----------MQSSGTSVTG---SSIASGTLAATS 376
            .|:|                  ..||:...          |......:.|   ::.|..|:|...
  Rat    98 AQRPHESGTYGFLDQAQHSDIKADCSNCVETEDRKVLRQPMNCEREQLRGNQEAAAAPDTMAQPY 162

  Fly   377 SSGVGLLPTTGLDSIANGGAP------TGCAVVPASTSQVIAHLNAAAAAASGIVSPSANVATSL 435
            :|.....|..|:.:......|      ||...||..|      ||        :..|:.  ..|.
  Rat   163 ASAQFAPPQNGIPAEYTAPHPHPAPEYTGQTTVPDHT------LN--------LYPPTQ--THSE 211

  Fly   436 SSALVPAQSVAAVAAASLDA-----------------KSQPKRLHVSNIPFRFRDPDLRAMFGQF 483
            .||...||:|:..|..:.||                 ||||||||||||||||||||||.|||||
  Rat   212 QSADTSAQTVSGTATQTDDAAPTDGQPQTQPSENTENKSQPKRLHVSNIPFRFRDPDLRQMFGQF 276

  Fly   484 GTILDVEIIFNERGSKGFGFVTFANSNDAERARERLHGTVVEGRKIEVNNATARVQTKKVTAVP- 547
            |.|||||||||||||||||||||.||.||:||||:||||||||||||||||||||.|.|....|
  Rat   277 GKILDVEIIFNERGSKGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTNKKAVNPY 341

  Fly   548 ----------------------------------------NVVLTKDGAIPAPALVCVQWPEAAV 572
                                                    ::|.|...::|.|..   .:|.|..
  Rat   342 TNGWKLNPVVGAVYSPDFYAGTVLLCQANQEGSSMYSGPSSLVYTSANSVPVPGF---PYPAATA 403

  Fly   573 AAAMRGVAIQ-RGH--------------VGVVGATPYHHPHHPHHHPALLAASAAAAQQQQQRQL 622
            |||.||..:: ||.              :...|...|..|.:.:   .||....||.:..|....
  Rat   404 AAAYRGAHLRGRGRTVYNTFRAAAPPPPIPAYGGVVYQEPVYGN---KLLQGGYAAYRYAQPTPA 465

  Fly   623 AAAA 626
            .|||
  Rat   466 TAAA 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rbfox1	NP_001246707.1	RRM	<454..>542	CDD:223796	80/104 (77%)
Rbfox1	NP_001246707.1	RRM_FOX1_like	460..535	CDD:240853	68/74 (92%)
Rbfox1	XP_038941736.1	RRM	<199..>354	CDD:223796	102/227 (45%)
		RRM_FOX1_like	253..328	CDD:409841	54/115 (47%)
		Fox-1_C	393..480	CDD:403573

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334674
Domainoid	1	1.000	127	1.000	Domainoid score	I5240
eggNOG	1	0.900	-	-		E1_KOG0125
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001186
OrthoInspector	1	1.000	-	-		otm44711
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR15597
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.800