Protein Alignment Rbfox1 and RBFOX2

DIOPT Version :9

• Sequence 1: NP_001246707.1
• Gene: Rbfox1 / 39198
• FlyBaseID: FBgn0052062
• Length: 962
• Species: Drosophila melanogaster
• Sequence 2: XP_006724248.1
• Gene: RBFOX2 / 23543
• HGNCID: 9906
• Length: 465
• Species: Homo sapiens
• Alignment Length: 412
• Identity: 142/412 - (34%)
• Similarity: 175/412 - (42%)
• Gaps: 126/412 - (30%)

  Fly   256 AESQQSSAMQNAGGGGNTGG-----------GGGGGGGGTPSSPLSNSPSSATASQAGGCGLTLN 309
            ||..|.......|.|....|           .|.||.|..|.  ||..|.:..|:..||.|:. |
Human     2 AEGAQPHQPPQLGPGAAARGMKRESELELPVPGAGGDGADPG--LSKRPRTEEAAADGGGGMQ-N 63

  Fly   310 GSAT-----------EGSMSGDTSPVASGEPL--LQTPPAHQQQQQQQQPLLCSSPTSMQSSGTS 361
            ...|           :|:....|:|.|..:|.  :..||..|.....:..:..:...:.|:...:
Human    64 EPLTPGYHGFPARDSQGNQEPTTTPDAMVQPFTTIPFPPPPQNGIPTEYGVPHTQDYAGQTGEHN 128

  Fly   362 VT--GSSIASGTLAATSSSGVGLLPTTGLDSI--ANGGAPTGCAVVPASTSQVIAHLNAAAAAAS 422
            :|  ||:.|.|..::.|       |:|...|:  ..|||.|
Human   129 LTLYGSTQAHGEQSSNS-------PSTQNGSLTQTEGGAQT------------------------ 162

  Fly   423 GIVSPSANVATSLSSALVPAQSVAAVAAASLDAKSQPKRLHVSNIPFRFRDPDLRAMFGQFGTIL 487
                              ..|.....::.:.::||.|||||||||||||||||||.||||||.||
Human   163 ------------------DGQQSQTQSSENSESKSTPKRLHVSNIPFRFRDPDLRQMFGQFGKIL 209

  Fly   488 DVEIIFNERGSKGFGFVTFANSNDAERARERLHGTVVEGRKIEVNNATARVQTKKVTAVP----- 547
            |||||||||||||||||||.||.||:||||:||||||||||||||||||||.|.|....|
Human   210 DVEIIFNERGSKGFGFVTFENSADADRAREKLHGTVVEGRKIEVNNATARVMTNKKMVTPYANGW 274

  Fly   548 ----------------------NVVLTKDGAIP---------------APALVCVQWPEAA-VAA 574
                                  :|.|..|.|:|               .|.:....:|.|| .||
Human   275 KLSPVVGAVYGPELYAASSFQADVSLGNDAAVPLSGRGGINTYIPLISLPLVPGFPYPTAATTAA 339

  Fly   575 AMRGVAIQ-RGHV--GVVGATP 593
            |.||..:: ||..  |.|.|.|
Human   340 AFRGAHLRGRGRTVYGAVRAVP 361

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rbfox1	NP_001246707.1	RRM	<454..>542	CDD:223796	77/87 (89%)
		RRM_FOX1_like	460..535	CDD:240853	68/74 (92%)
RBFOX2	XP_006724248.1	RRM	<165..>266	CDD:223796	79/100 (79%)
		RRM_FOX1_like	182..257	CDD:240853	68/74 (92%)
		Fox-1_C	326..>383	CDD:289199	14/36 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141009
Domainoid	1	1.000	127	1.000	Domainoid score	I5360
eggNOG	1	0.900	-	-		E1_KOG0125
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001186
OrthoInspector	1	1.000	-	-		otm40573
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR15597
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2530
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.830