Protein Alignment Rbfox1 and RBFOX3

DIOPT Version :9

• Sequence 1: NP_001246707.1
• Gene: Rbfox1 / 39198
• FlyBaseID: FBgn0052062
• Length: 962
• Species: Drosophila melanogaster
• Sequence 2: NP_001372733.1
• Gene: RBFOX3 / 146713
• HGNCID: 27097
• Length: 373
• Species: Homo sapiens
• Alignment Length: 783
• Identity: 178/783 - (22%)
• Similarity: 212/783 - (27%)
• Gaps: 432/783 - (55%)

  Fly   202 LAEPRVPGPIPHPLTNGHAVDQVQQP--PVQQQHLQSSLPPQNVLSISTVLIANEAAESQQSSAM 264
            :|:|..|...|.|..||...:....|  |.|....|:.:|.::.:::.|
Human     1 MAQPYPPAQYPPPPQNGIPAEYAPPPPHPTQDYSGQTPVPTEHGMTLYT---------------- 49

  Fly   265 QNAGGGGNTGGGGGGGGGGTPSSPLSNSPSSATASQAGGCGLTLNGSATEGSMSGDTSPVASGEP 329
                                        |:.....|.|          :|.|    |.|:|..:.
Human    50 ----------------------------PAQTHPEQPG----------SEAS----TQPIAGTQT 72

  Fly   330 LLQTPPAHQQQQQQQQPLLCSSPTSMQSSGTSVTGSSIASGTLAATSSSGVGLLPTTGLDSIANG 394
            :.||..|   .|...|||..|.||.
Human    73 VPQTDEA---AQTDSQPLHPSDPTE---------------------------------------- 94

  Fly   395 GAPTGCAVVPASTSQVIAHLNAAAAAASGIVSPSANVATSLSSALVPAQSVAAVAAASLDAKSQP 459
                                                                         |.||
Human    95 -------------------------------------------------------------KQQP 98

  Fly   460 KRLHVSNIPFRFRDPDLRAMFGQFGTILDVEIIFNERGSKGFGFVTFANSNDAERARERLHGTVV 524
            ||||||||||||||||||.||||||.|||||||||||||||||||||..|:||:||||:|:||:|
Human    99 KRLHVSNIPFRFRDPDLRQMFGQFGKILDVEIIFNERGSKGFGFVTFETSSDADRAREKLNGTIV 163

  Fly   525 EGRKIEVNNATARVQTKKVTAVPNVVLTKDGAIPAPALVCVQWPEAAVAAAMRGVAIQRGHVGVV 589
            ||||||||||||||.|.|.|
Human   164 EGRKIEVNNATARVMTNKKT--------------------------------------------- 183

  Fly   590 GATPYHHPHHPHHHPALLAASAAAAQQQQQRQLAAAAVATAAVAQQQQQQQQAVVQQQQQQVAAA 654
             ..||
Human   184 -GNPY------------------------------------------------------------ 187

  Fly   655 AQQQHQQQQQQQQQAVQQQQAVQQQQQHQQQQQQQQQQQHAAVAAAAAAASHPHMHAAHAHAHAH 719
                                                                             
Human   188 ----------------------------------------------------------------- 187

  Fly   720 ALGPQLAQLQAVAVPTAASNAAALQQSLAAAIQNPSGNPNAAAAAAAYAARLSAATGATQSPQTA 784
                              :|...|             ||   ...|.|.....|.||... |.|.
Human   188 ------------------TNGWKL-------------NP---VVGAVYGPEFYAVTGFPY-PTTG 217

  Fly   785 AAAAAAASMAASANAANNAAALHGFAPVYYDPFLAAAASADPNLRFQAAKPVTEVPAAQPAAILN 849
            .|            .|...|.|.|.....|:             .|:||.|...:|....|.
Human   218 TA------------VAYRGAHLRGRGRAVYN-------------TFRAAPPPPPIPTYGAAL--- 254

  Fly   850 RRTVTTLNSNPHTINRIPVPQNVLATAPLLKTPLSQAQQQAYATAAT---TYTAVAARAAY---- 907
                      ..|:.::|||...||..||   |..|..:.||.|:..   .....|:|..|
Human   255 ----------EQTLVKMPVPWAGLAPCPL---PPQQTPEPAYPTSPAFPPLSCPFASRVVYQDGF 306

  Fly   908 -------GAAAAAAAQPALAGYATVAGYAREY--ADPYLGHGIGPVPGYG----ATMYRGGFNRF 959
                   |.||...||||.|..|....|.|.|  |||| .|.|||...|.    |::.|||::||
Human   307 YGAEIYGGYAAYRYAQPAAAAAAYSDSYGRVYAAADPY-HHTIGPAATYSIGTMASLCRGGYSRF 370

  Fly   960 TPY 962
            |||
Human   371 TPY 373

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rbfox1	NP_001246707.1	RRM	<454..>542	CDD:223796	74/87 (85%)
		RRM_FOX1_like	460..535	CDD:240853	65/74 (88%)
RBFOX3	NP_001372733.1	RRM	27..232	CDD:223796	117/584 (20%)
		RRM_FOX1_like	99..174	CDD:409841	65/74 (88%)
		Fox-1_C	208..344	CDD:403573	46/177 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141008
Domainoid	1	1.000	127	1.000	Domainoid score	I5360
eggNOG	1	0.900	-	-		E1_KOG0125
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001186
OrthoInspector	1	1.000	-	-		otm40573
orthoMCL	1	0.900	-	-		OOG6_106936
Panther	1	1.100	-	-	LDO	PTHR15597
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2530
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.770