DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12362 and HEL1

DIOPT Version :9

Sequence 1:	NP_648392.1	Gene:	CG12362 / 39193	FlyBaseID:	FBgn0036082	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_012942.3	Gene:	HEL1 / 853887	SGDID:	S000001725	Length:	551	Species:	Saccharomyces cerevisiae

Alignment Length:	517	Identity:	154/517 - (29%)
Similarity:	234/517 - (45%)	Gaps:	91/517 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 DSDSEDTCTEILL--PENSNSP------ETEDFVYKVLSVDQIVQHQRNIIDEVNNVLNLPPQVT 84
            |.|..||..|.:|  |...|:.      ...:..|:.|:...|.:.....:|.:..:..:|....
Yeast    57 DEDGVDTIYEGMLDAPLTKNNKRILCEGSVPNLSYECLTTKGIFERMLQRVDHLQPIFAIPSADI 121

  Fly    85 RIILNHFKWDKESLFENYFE--------------SNPK---DF---FQRAHVLNPFEKKIERESA 129
            .|:|.|:.|::|.|.|.:.|              :|.|   |:   |:.....|.|
Yeast   122 LILLQHYDWNEERLLEVWTEKMDELLVELGLSTTANIKKDNDYNSHFREVEFKNDF--------- 177

  Fly   130 ASTSCAIPQLCGICFCSCD----ELIGLGCGHNFCAACWKQYLANKTCSEGLANTIKCPAA---- 186
                     .|.||   ||    |...|.|||.:|..|::.|:.:|.....:...:.|..|
Yeast   178 ---------TCIIC---CDKKDTETFALECGHEYCINCYRHYIKDKLHEGNIITCMDCSLALKNE 230

  Fly   187 NCEILVDYISFLKLADDSEVVERYQQLITNTFVE-CNMLMRWCPAPNCSHAV--KAVCAEPR--- 245
            :.:.::.:.|..||.|.|          ..:||: .|...:|||..:|...|  :...:.|.
Yeast   231 DIDKVMGHPSSSKLMDSS----------IKSFVQKHNRNYKWCPFADCKSIVHLRDTSSLPEYTR 285

  Fly   246 -----AVLCKCGHEFCFACGENWHEPASCSSLKKWVKKCLEDSETSNWIAQNTKECPKCNVTIEK 305
                 .|.|...|.|||.||...|.||.|.....||||..::||..||:..:|||||||:|.|||
Yeast   286 LHYSPFVKCNSFHRFCFNCGFEVHSPADCKITTAWVKKARKESEILNWVLSHTKECPKCSVNIEK 350

  Fly   306 DGGCNHMVCKNPSCRYDFCWVCLGSWEPHGSSWYSCNRFDEEEAKQARLAQQKYRSSMARYLHYY 370
            :||||||||.  ||:|:|||:|.|.|.|||.:::.|..:...|..:::..|.. ..::.:|..||
Yeast   351 NGGCNHMVCS--SCKYEFCWICEGPWAPHGKNFFQCTMYKNNEDNKSKNPQDA-NKTLKKYTFYY 412

  Fly   371 NRYSNHMQSLKMENKLYSNIQAKMDDMQEE--MSWIEVQFLRDAVDVLCQCRTTLMYSYVFAFYL 433
            ..::.|..|.|::..|...:..|:..:||.  :|||:.|||.:::.||.:.||.|.:|:..|:|.
Yeast   413 RLFNEHEVSAKLDWNLGQTLGTKVHALQERIGISWIDGQFLSESLKVLNEGRTVLKWSFAVAYYS 477

  Fly   434 -MNNNQKIIFEDNQKDMEMATEKLSECLE---REITVKNIYEVKQKVLDLSHYCQKRRHVLL 491
             .::|...||.|||..:..|.|.|||.|:   .|:.:|...|...|    :.|.:.|...|:
Yeast   478 DASHNLTKIFVDNQMLLANAVESLSELLQIKTPEVIMKRRPEFYNK----AGYVENRTTALM 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12362	NP_648392.1	IBR	208..269	CDD:214763	20/71 (28%)
CG12362	NP_648392.1	IBR	273..331	CDD:279784	35/57 (61%)
HEL1	NP_012942.3	RING-HC_RBR_HEL2_like	177..222	CDD:319539	15/65 (23%)
		IBR	243..311	CDD:396187	22/77 (29%)
		IBR	<342..374	CDD:396187	23/33 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346644
Domainoid	1	1.000	89	1.000	Domainoid score	I1792
eggNOG	1	0.900	-	-		E1_KOG1815
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	241	1.000	Inparanoid score	I689
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54219
OrthoFinder	1	1.000	-	-		FOG0000379
OrthoInspector	1	1.000	-	-		otm46647
orthoMCL	1	0.900	-	-		OOG6_100963
Panther	1	1.100	-	-	O	PTHR11685
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.760