DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12362 and Sharpin

DIOPT Version :9

Sequence 1:	NP_648392.1	Gene:	CG12362 / 39193	FlyBaseID:	FBgn0036082	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_112415.1	Gene:	Sharpin / 81859	RGDID:	631353	Length:	381	Species:	Rattus norvegicus

Alignment Length:	112	Identity:	24/112 - (21%)
Similarity:	36/112 - (32%)	Gaps:	21/112 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 TCTEILLPENSNSPETEDFVYKVLSVDQIVQHQRNII---DEVNNVLNLPPQVTRIILNHFKWDK 95
            |..|:.||:.|.:          |..:::..|....|   ||     ....||..|:..|.....
  Rat   154 TQPEMDLPQGSGN----------LKKEELATHLAQAIAGGDE-----KAAAQVAAILAQHHVALN 203

  Fly    96 ESLFENYFESNPKDFFQRAHVLNPFEKKIERESAASTSCAIPQLCGI 142
            ..|.|.:|...|   .:....:......:...|:|..|..|...|.|
  Rat   204 VQLLEAWFPRGP---IRLQVTVEDATSVLSSSSSAHVSLQIHPHCSI 247

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12362	NP_648392.1	IBR	208..269	CDD:214763
CG12362	NP_648392.1	IBR	273..331	CDD:279784
Sharpin	NP_112415.1	Self-association. /evidence=ECO:0000269\|PubMed:11178875	1..177		7/32 (22%)
		Sharpin_PH	18..125	CDD:407032
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	121..153
		Interaction with SHANK1. /evidence=ECO:0000269\|PubMed:11178875	172..305		18/84 (21%)
		Ubl_HOIL1	215..299	CDD:340497	7/36 (19%)
		zf-RanBP	346..370	CDD:395516
		RanBP2-type Zn finger	346..365	CDD:275376
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1815
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900