DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12362 and ARI2

DIOPT Version :9

Sequence 1:	NP_648392.1	Gene:	CG12362 / 39193	FlyBaseID:	FBgn0036082	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_179206.2	Gene:	ARI2 / 816106	AraportID:	AT2G16090	Length:	593	Species:	Arabidopsis thaliana

Alignment Length:	533	Identity:	160/533 - (30%)
Similarity:	262/533 - (49%)	Gaps:	66/533 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNSEMEFSDED--HGDSHRSLLTHMSCENDSDSEDTCTEILLPENSNSPETEDFVYKVLSVDQIV 63
            |:..:...:||  :.....||       |..|::::   :.:|.:|.|.     ..||::.:.::
plant     1 MDDNLSGEEEDYYYSSDQESL-------NGIDNDES---VSIPVSSRSN-----TVKVITKESLL 50

  Fly    64 QHQRNIIDEVNNVLNLPPQVTRIILNHFKWDKESLFENYFESNPKDFFQRAHVLNPFEKKIERES 128
            ..||..:..|..:|::.....|.:|.|::||.|.||....|......|..|.|     ..:|.:|
plant    51 AAQREDLRRVMELLSVKEHHARTLLIHYRWDVEKLFAVLVEKGKDSLFSGAGV-----TLLENQS 110

  Fly   129 AASTSCAIPQL--CGICFCSCD--ELIGLGCGHNFCAACWKQYLANKTCSEGLANTIKCPAANCE 189
            ..|:......:  |.||.....  :|..:.|||:||..||..:...| .:||.:..|.|.|..|.
plant   111 CDSSVSGSSSMMSCDICVEDVPGYQLTRMDCGHSFCNNCWTGHFTVK-INEGQSKRIICMAHKCN 174

  Fly   190 ILV--DYISFLKLADDSEVVERYQQLITNTFVECNMLMRWCPA-PNCSHAVKAVCAEPRAVLCKC 251
            .:.  |.:..|......::.|::.:.:..:::|.|.:::|||: |:|.:|::....|...|.|.|
plant   175 AICDEDVVRALVSKSQPDLAEKFDRFLLESYIEDNKMVKWCPSTPHCGNAIRVEDDELCEVECSC 239

  Fly   252 GHEFCFACGENWHEPASCSSLKKWVKKCLEDSETSNWIAQNTKECPKCNVTIEKDGGCNHMVCKN 316
            |.:|||:|....|.|.||...:.|.|||.::|||.|||..:||.||||:..:||:||||.:.|
plant   240 GLQFCFSCSSQAHSPCSCVMWELWRKKCFDESETVNWITVHTKPCPKCHKPVEKNGGCNLVTC-- 302

  Fly   317 PSCRYDFCWVCLGSWEPHGSSW-----YSCNRFDEEEAKQARLAQQKYRSSMARYLHYYNRYSNH 376
             .||..|||:| |.......:|     :||.||.|::.||    .::.:..:.||:||:|||..|
plant   303 -LCRQSFCWLC-GEATGRDHTWARISGHSCGRFQEDKEKQ----MERAKRDLKRYMHYHNRYKAH 361

  Fly   377 MQSLKMENKLYSNIQAKMD-DMQEEMSWIEVQFLRDAVDVLCQCRTTLMYSYVFAFYL------- 433
            :.|.|:|.||.:||..|:. ..:.|:...:..:..:.:..|.:.|..|.|||.||||:
plant   362 IDSSKLEAKLSNNISKKVSISEKRELQLKDFSWATNGLHRLFRSRRVLSYSYPFAFYMFGDELFK 426

  Fly   434 --MNNNQKII----FEDNQKDMEMATEKLSECLER---EITVKNIYEVKQKVLDLSHYCQKRRHV 489
              |::.::.|    |||.|:.:|...||||:.||.   :.....:.:::.:|::||....
plant   427 DEMSSEEREIKQNLFEDQQQQLEANVEKLSKFLEEPFDQFADDKVMQIRIQVINLSVAVD----- 486

  Fly   490 LLC-HVREGYEND 501
            .|| ::.|..|||
plant   487 TLCENMYECIEND 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12362	NP_648392.1	IBR	208..269	CDD:214763	20/61 (33%)
CG12362	NP_648392.1	IBR	273..331	CDD:279784	30/57 (53%)
ARI2	NP_179206.2	RING_Ubox	126..174	CDD:418438	16/48 (33%)
		IBR	195..257	CDD:214763	20/61 (33%)
		IBR	<283..314	CDD:396187	17/34 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	81	1.000	Domainoid score	I2944
eggNOG	1	0.900	-	-		E1_KOG1815
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D469819at2759
OrthoFinder	1	1.000	-	-		FOG0000379
OrthoInspector	1	1.000	-	-		mtm1176
orthoMCL	1	0.900	-	-		OOG6_100963
Panther	1	1.100	-	-	O	PTHR11685
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.780