DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12362 and Rnf19b

DIOPT Version :9

Sequence 1:	NP_648392.1	Gene:	CG12362 / 39193	FlyBaseID:	FBgn0036082	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_001355692.1	Gene:	Rnf19b / 75234	MGIID:	1922484	Length:	732	Species:	Mus musculus

Alignment Length:	228	Identity:	64/228 - (28%)
Similarity:	98/228 - (42%)	Gaps:	36/228 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 ERESAASTSCAIPQLCGICFCSCDELIG---------LGCGHNFCAACWKQYLANKTCSEGLANT 180
            |.:.||....|....|.:|      |:.         |.|.|..|..|.:.||..:.....:  .
Mouse   101 EEDEAAEGGGAEEVECPLC------LVRLPPERAPRLLSCPHRSCRDCLRHYLRLEISESRV--P 157

  Fly   181 IKCPAANCEILVDYISFLKLADDSEVVERYQQLITNTFVECNMLMRWCPAPNCSHAVKAV-CAEP 244
            |.||  .|...::......|..|..::.:|::.:...::..:...||||||:|.:||.|. ||..
Mouse   158 ISCP--ECSERLNPHDIRLLLADPPLMHKYEEFMLRRYLASDPDCRWCPAPDCGYAVIAYGCASC 220

  Fly   245 RAVLCK---CGHEFCFACGENWHEPASCSSLKKWVKKCL--EDSETS-------NWIAQNTKECP 297
            ..:.|:   |..|||:.|.:.||...:|...::...:.|  ....||       :..|.:.|.||
Mouse   221 PKLTCEREGCQTEFCYHCKQIWHPNQTCDMARQQRAQTLRVRTKHTSGLSYGQESGPADDIKPCP 285

  Fly   298 KCNVTIEK--DGGCNHMVCKNPSCRYDFCWVCL 328
            :|:..|.|  ||.||||.|  ..|..:|||:|:
Mouse   286 RCSAYIIKMNDGSCNHMTC--AVCGCEFCWLCM 316

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12362	NP_648392.1	IBR	208..269	CDD:214763	21/64 (33%)
CG12362	NP_648392.1	IBR	273..331	CDD:279784	22/67 (33%)
Rnf19b	NP_001355692.1	Required for ubiquitin ligase activity and for protection against staurosporin-induced cell death. /evidence=ECO:0000250\|UniProtKB:Q6ZMZ0	1..315		63/225 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..109		3/7 (43%)
		TRIAD supradomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01221	112..334		60/217 (28%)
		RING-HC_RBR_RNF19B	116..169	CDD:319690	14/62 (23%)
		RING-HC finger (C3HC4-type)	116..163	CDD:319690	13/56 (23%)
		IBR	184..248	CDD:214763	21/63 (33%)
		IBR	<280..318	CDD:307574	18/39 (46%)
		AzlC	<344..433	CDD:351157
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	598..644
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	660..732
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1815
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810