DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12362 and Cul7

DIOPT Version :9

Sequence 1:	NP_648392.1	Gene:	CG12362 / 39193	FlyBaseID:	FBgn0036082	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_079887.3	Gene:	Cul7 / 66515	MGIID:	1913765	Length:	1689	Species:	Mus musculus

Alignment Length:	657	Identity:	123/657 - (18%)
Similarity:	197/657 - (29%)	Gaps:	221/657 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 EDHGDSHRSLLTHMSCENDS--DSEDTCTEILLPENSNSPETEDFVYKVLSVDQIVQHQRNIIDE 72
            :|..:..|||| |:|...:.  ..|....|..||:...:.......::.| |..:||:..:..::
Mouse   977 QDIAEDRRSLL-HLSSRLNGALRHEQNFAERFLPDMEAAQALSKTCWEAL-VSPLVQNITSPDED 1039

  Fly    73 VNNVLNLPPQVTRIILNHFKWDKESLFENYFESNPKD----FFQRAHVLNPFEKKIERESAASTS 133
            ..:.|..       :|:.:...:|:.:      ||:.    |..|...|......:|...||...
Mouse  1040 STSSLGW-------LLDQYLGCREAAY------NPQSRAAAFSSRVRRLTHLLVHVEPREAAPPV 1091

  Fly   134 CAIPQLCG------------------------ICFCS-CDELIGLGCGHNFCAACWKQ------- 166
            .|||:..|                        .|:.| .:|.:     :.|..|.||.
Mouse  1092 VAIPRSKGRNRIHDWSYLITRGLPSSIMKNLTRCWRSVVEEQM-----NKFLTASWKDDDFVPRY 1151

  Fly   167 ----YLANKTCSEGLANTIKCPAA--------NCEILVDYISFLKLADDSEVVERY--QQLITNT 217
                |:..|:.||     :..|.|        .|...|..:.||:.|..||...|:  |::..:.
Mouse  1152 CERYYVLQKSSSE-----LFGPRAAFLLAMRNGCADAVLRLPFLRAAHVSEQFARHIDQRIQGSR 1211

  Fly   218 FVECNMLMRWCPAPNCSHAVKAVCAEPRAVLCKCGHEF-------CFACGENWHE--------PA 267
            ......:........|..:|  :...|..:.....|.:       ..:.|.:|.|        |.
Mouse  1212 MGGARGMEMLAQLQRCLESV--LIFSPLEIATTFEHYYQHYMADRLLSVGSSWLEGAVLEQIGPC 1274

  Fly   268 SCSSLKKWVKKCLEDSETSN------WIAQNTKECPKCNVTIEK------DGGCNHMVCKNPSCR 320
            ..|.|.:.:.:.|..||...      .:.|..:|..|...|.:|      |.| .....|.....
Mouse  1275 FPSRLPQQMLQSLNVSEELQRQFHVYQLQQLDQELLKLEDTEKKIQVAHEDSG-REDKSKKEEAI 1338

  Fly   321 YDFCWVCLGSWEPHGSSWYSCNRFDEEEAKQARLAQQKYRSSMAR-------------------- 365
            .:...|.:...|..|..    ...:||...:....::.|:.:|..
Mouse  1339 GEAAAVAMAEEEDQGKK----EEGEEEGEGEDEEEERYYKGTMPEVCVLVVTPRFWPVASVCQML 1399

  Fly   366 --------YL-----HYYNRYSNHMQSLKMENKLYSNIQAKMDDMQEEMSW-----IEVQFLRDA 412
                    ||     ||.|.||.......:|.           :.|..:.|     .||||....
Mouse  1400 NPATCLPAYLRGTINHYTNFYSKSQSRSSLEK-----------EPQRRLQWTWQGRAEVQFGGQI 1453

  Fly   413 VDVLCQCRTTLMYSYVFAFYLMN-NNQKIIFEDNQKDMEMATEKLSECLEREI------------ 464
            :.|          |.|..:.|:: ||||   |.:.:.::..:|...:.|.|.|
Mouse  1454 LHV----------STVQMWLLLHLNNQK---EVSVESLQAISELPPDVLHRAIGPLTSSRGPLDL 1505

  Fly   465 -TVKNIYEVKQKVLDLSH----------------YCQ----------KRRHVLLC--------HV 494
             ..||:.....|:.|.|.                |.|          |||::|.|        |.
Mouse  1506 QEQKNVPGGVLKIRDDSEEPRPRRGNVWLIPPQTYLQAEAEEGRNMEKRRNLLNCLVVRILKAHG 1570

  Fly   495 REGYEND 501
            .||...|
Mouse  1571 DEGLHVD 1577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12362	NP_648392.1	IBR	208..269	CDD:214763	10/77 (13%)
CG12362	NP_648392.1	IBR	273..331	CDD:279784	12/69 (17%)
Cul7	NP_079887.3	Interaction with TP53. /evidence=ECO:0000250	349..449
		Cul7	352..423	CDD:288381
		APC10-like	817..947	CDD:295192
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1321..1371		8/54 (15%)
		Cullin_Nedd8	1552..1630	CDD:299553	9/26 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D469819at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010