DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12362 and rnf19b

DIOPT Version :9

Sequence 1:	NP_648392.1	Gene:	CG12362 / 39193	FlyBaseID:	FBgn0036082	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_001189369.1	Gene:	rnf19b / 562396	ZFINID:	ZDB-GENE-060503-281	Length:	701	Species:	Danio rerio

Alignment Length:	207	Identity:	66/207 - (31%)
Similarity:	98/207 - (47%)	Gaps:	26/207 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   140 CGICFC--SCDELIGL-GCGHNFCAACWKQYLANKTCSEGLANTIKCPAANCEILVDYISFLKLA 201
            |.:|..  ..::|..| ||.|..|..|.:|||..:.....:  .:.||.. .|.|..:...| :.
Zfish   107 CPLCLVRQPAEQLPELQGCSHRSCLCCLRQYLRIEITESRV--QLSCPEC-AERLAPWQVAL-IL 167

  Fly   202 DDSEVVERYQQLITNTFVECNMLMRWCPAPNCSHAVKAV-CAEPRAVLCK---CGHEFCFACGEN 262
            ||..::|:|::.:....:..:...||||||:|..||.|. ||....::|:   ||.|||:.|.:.
Zfish   168 DDPNLMEKYEEFLLRRCLASDPDCRWCPAPDCGFAVIASGCASCPRLVCRREGCGAEFCYHCKQA 232

  Fly   263 WHEPASCSSLKKWVKKCLEDSETSNWIAQNT---------KECPKCNVTIEK--DGGCNHMVCKN 316
            ||...:|.|.::  ::.|.....||.....|         |.||:|...|.|  ||.||||.|
Zfish   233 WHPNQTCDSARQ--QRALSLRTHSNHSPSYTAEQGHTDDIKPCPRCGAYIIKMNDGSCNHMTC-- 293

  Fly   317 PSCRYDFCWVCL 328
            ..|..:|||:|:
Zfish   294 AVCGCEFCWLCM 305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12362	NP_648392.1	IBR	208..269	CDD:214763	23/64 (36%)
CG12362	NP_648392.1	IBR	273..331	CDD:279784	22/67 (33%)
rnf19b	NP_001189369.1	Required for ubiquitin ligase activity and for protection against staurosporin-induced cell death. /evidence=ECO:0000250\|UniProtKB:Q6ZMZ0	1..304		65/204 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..97
		TRIAD supradomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01221	103..323		66/207 (32%)
		IBR	174..239	CDD:214763	23/64 (36%)
		IBR	<269..307	CDD:279784	18/39 (46%)
		TauE	<329..>421	CDD:280159
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	472..495
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	658..677
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1815
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810