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Protein Alignment CG12362 and ANKIB1

DIOPT Version :9

Sequence 1:	NP_648392.1	Gene:	CG12362 / 39193	FlyBaseID:	FBgn0036082	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_061877.1	Gene:	ANKIB1 / 54467	HGNCID:	22215	Length:	1089	Species:	Homo sapiens

Alignment Length:	606	Identity:	170/606 - (28%)
Similarity:	264/606 - (43%)	Gaps:	130/606 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 FSDEDHGDSHRSLLTHMSCENDSDSEDTCTEILLPEN----SNSPETEDFVYKVLSVDQIVQHQ- 66
            |::.::.|      |...|......:|....:   |:    |..||.|:...:..::|:...::
Human   172 FAENENKD------TPCDCAEKQHHKDLALNL---ESQMVFSRDPEAEEIEAEYAALDKREPYEG 227

  Fly    67 ------RNIID----EVNNVLNLPPQVTRIILNHFKWDKESLFENYFESNPKDFFQRAHVL---- 117
                  |.:.|    |..::|..|......:|....||:|.|.|.:. |||::..||:.|.
Human   228 LRPQDLRRLKDMLIVETADMLQAPLFTAEALLRAHDWDREKLLEAWM-SNPENCCQRSGVQMPTP 291

  Fly   118 ------------NPFEKKIERESAAS------------TSCAIPQLCGICFCSC---DELIGLGC 155
                        :|...:..|.|..|            ||     ||.||.||.   ::.:.:.|
Human   292 PPSGYNAWDTLPSPRTPRTTRSSVTSPDEISLSPGDLDTS-----LCDICMCSISVFEDPVDMPC 351

  Fly   156 GHNFCAACWKQYLANKTCSEGLANTIKCPAANCEILVDYISFLKLADDSEVVERYQQLITNTFVE 220
            ||:||..||:.:| |....||.|:.|.|||.:|..||. :..::.....|:.:||.|.....|||
Human   352 GHDFCRGCWESFL-NLKIQEGEAHNIFCPAYDCFQLVP-VDIIESVVSKEMDKRYLQFDIKAFVE 414

  Fly   221 CNMLMRWCPAPNCSHAVKAV---------------CAEPRAVLCKCGHEFCFACGENWHEPASCS 270
            .|..::|||.|.|..||:..               .....||.|..||.||:.|....|||..|.
Human   415 NNPAIKWCPTPGCDRAVRLTKQGSNTSGSDTLSFPLLRAPAVDCGKGHLFCWECLGEAHEPCDCQ 479

  Fly   271 SLKKWVKK--------------CLEDSETSNWIAQNTKECPKCNVTIEKDGGCNHMVCKNPSCRY 321
            :.|.|::|              ..||:....|:..|:|.|..|...|:|:.|||||.|  ..|:|
Human   480 TWKNWLQKITEMKPEELVGVSEAYEDAANCLWLLTNSKPCANCKSPIQKNEGCNHMQC--AKCKY 542

  Fly   322 DFCWVCLGSWEPHGSS---WYSCNRFD-----EEEAKQARL-AQQKYR--SSMARYLHYYNRYSN 375
            ||||:||..|:.|.||   :|.|.|::     ||::|:..: |::|::  ..:.|::|||.|:.|
Human   543 DFCWICLEEWKKHSSSTGGYYRCTRYEVIQHVEEQSKEMTVEAEKKHKRFQELDRFMHYYTRFKN 607

  Fly   376 HMQSLKMENKLYSNIQAKMDDMQEEMSWIE-----VQFLRDAVDVLCQCRTTLMYSYVFAFYL-M 434
            |..|.::|.:|....:.||:.:...:...|     ..|:.|||.||.:.|..|..||.:.|:| .
Human   608 HEHSYQLEQRLLKTAKEKMEQLSRALKETEGGCPDTTFIEDAVHVLLKTRRILKCSYPYGFFLEP 672

  Fly   435 NNNQKIIFEDNQKDMEMATEKLSECLEREITVKNIYEVKQKVLDLSHYCQKRRHVLLCHVREGYE 499
            .:.:|.|||..|.|:||.||.|::.:.|..    :...:.|::..:...|::|...|..|..|..
Human   673 KSTKKEIFELMQTDLEMVTEDLAQKVNRPY----LRTPRHKIIKAACLVQQKRQEFLASVARGVA 733

  Fly   500 --------------NDW-WEF 505
                          ..| ||:
Human   734 PADSPEAPRRSFAGGTWDWEY 754

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.