Protein Alignment CG12362 and arih2

DIOPT Version :10

• Sequence 1: NP_648392.1
• Gene: CG12362 / 39193
• FlyBaseID: FBgn0036082
• Length: 511
• Species: Drosophila melanogaster
• Sequence 2: NP_001005678.1
• Gene: arih2 / 448178
• XenbaseID: XB-GENE-1014785
• Length: 491
• Species: Xenopus tropicalis
• Alignment Length: 515
• Identity: 152/515 - (29%)
• Similarity: 265/515 - (51%)
• Gaps: 58/515 - (11%)

  Fly     1 MNSEMEFSDEDHGDSHRSLLTHMSCENDSDSEDT-----------CTEILLPENSNSPETEDFVY 54
            |||:...|:||:..         :||::.:.||.           ....:..:.::|.:.|::.:
 Frog     5 MNSQGSDSNEDYDP---------NCEDEEEEEDDDPGDIEDYYVGVANDVEQQGADSFDPEEYQF 60

  Fly    55 KVLSVDQIVQHQRNIIDEVNNVLNLPPQVTRIILNHFKWDKESLFENYFESNPKDFFQRAHVLNP 119
            ..|:..:........:..::::|.:...|.::||.||.|....:.|.             |.||.
 Frog    61 TCLTYRESESALNEQMANLSSMLKVSHSVAKLILVHFHWQVSEIVER-------------HKLNS 112

  Fly   120 ----FEKKIERESAASTSCAIPQLCGIC--FCSCDELIGLGCGHNFCAACWKQYLANKTCS---- 174
                .|.:::..|:..........|.:|  |...:.|:.|.|.|.||.:||:|:     |:
 Frog   113 AQLLVEARVQLLSSKHVMAHSSHHCAVCMQFVRKENLLSLACQHQFCRSCWEQH-----CTVLVK 172

  Fly   175 EGLANTIKCPAANCEILVDYISFLKLADDSEVVERYQQLITNTFVECNMLMRWCPAPNCSHAVKA 239
            :|....|.|.|..|.:.........|..:.|:.::|::.:...:||.:..::.||..:|...::.
 Frog   173 DGAGVGISCMAQECLLRTPEDFVFPLLPNEELKDKYRRYLFRDYVESHYQLQLCPGADCPMVIQV 237

  Fly   240 VCAEPRAVLC-KCGHEFCFACGENWHEPASCSSLKKWVKKCLEDSETSNWIAQNTKECPKCNVTI 303
            ...:.|.|.| :|...|||.|.:.:|.|..|::::||:.||.:||||:|:|:.:||:|||||:.|
 Frog   238 QEPKARRVQCNRCSEVFCFRCRQMYHAPTDCATIRKWLTKCADDSETANYISAHTKDCPKCNICI 302

  Fly   304 EKDGGCNHMVCKNPSCRYDFCWVCLGSWEPHGSSWYSCNRFDEEEAKQARLAQQKYRSSMARYLH 368
            ||:||||||.|.  .|::||||:|||.|:.|||.:|.|:|:.|......:..|.:.|.::.:||.
 Frog   303 EKNGGCNHMQCS--KCKHDFCWMCLGDWKTHGSEYYECSRYKENPDIVNQSQQAQAREALKKYLF 365

  Fly   369 YYNRYSNHMQSLKMENKLYSNIQAKMDD--MQEEMSWIEVQFLRDAVDVLCQCRTTLMYSYVFAF 431
            |:.|:.||.:||::|.:.|..||.|:.:  |....:||:.|:|::|..:|.:||.||.|:|.:|:
 Frog   366 YFERWENHNKSLQLEAQTYQQIQEKIQERVMNNLGTWIDWQYLQNAAKLLAKCRYTLQYTYPYAY 430

  Fly   432 YLMNNNQKIIFEDNQKDMEMATEKLSECLEREITVKNIYEVKQKVLDLSHYCQKRRHVLL 491
            |:.:..:|.:||..|..:|...|.||..:||    .:.|: :..:.:..|..::||..||
 Frog   431 YMESGPRKKLFEYQQAQLEAEIENLSWKVER----ADSYD-RGDLENQMHIAEQRRRTLL 485

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12362	NP_648392.1	RING-HC_RBR_HHARI	138..194	CDD:438288	18/61 (30%)
		BRcat_RBR_HHARI-like	203..284	CDD:439004	23/81 (28%)
		Rcat_RBR_HHARI-like	288..345	CDD:439017	33/56 (59%)
		Ariadne	346..>480	CDD:466073	42/135 (31%)
arih2	NP_001005678.1	RING-HC_RBR_TRIAD1	135..186	CDD:438429	17/55 (31%)
		BRcat_RBR_TRIAD1	215..286	CDD:439005	24/70 (34%)
		Rcat_RBR_TRIAD1	290..345	CDD:439021	33/56 (59%)
		Ariadne	350..>476	CDD:466073	41/130 (32%)