DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12362 and Ankib1

DIOPT Version :9

Sequence 1:	NP_648392.1	Gene:	CG12362 / 39193	FlyBaseID:	FBgn0036082	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	XP_006236111.1	Gene:	Ankib1 / 368062	RGDID:	1597088	Length:	1091	Species:	Rattus norvegicus

Alignment Length:	588	Identity:	168/588 - (28%)
Similarity:	256/588 - (43%)	Gaps:	113/588 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 EDHGDSHRSLLTHMSCENDSDSEDTCTEILLPENSNSPETEDFVYKVLSVDQIVQHQRNIIDEVN 74
            :.|.|...||.:.|....|.::|:...|....:....       |:.|....:.:.:..:|.|..
  Rat   189 QHHKDLALSLESQMVFSRDPEAEEIEAEYAALDKREP-------YEGLRPQDLRRLKDMLIVETA 246

  Fly    75 NVLNLPPQVTRIILNHFKWDKESLFENYFESNPKDFFQRAHVL----------------NPFEKK 123
            ::|..|......:|....||:|.|.|.:. |||::..||:.|.                :|...:
  Rat   247 DMLQAPLFTAEALLRAHDWDREKLLEAWM-SNPENCCQRSGVQMPAPPPSGCNAWDTLPSPRTPR 310

  Fly   124 IERESAAS------------TSCAIPQLCGICFCSC---DELIGLGCGHNFCAACWKQYLANKTC 173
            ..|.|..|            ||     ||.||.||.   ::.:.:.|||:||..||:.:| |...
  Rat   311 TTRSSVTSPDEISLSPGDLDTS-----LCDICMCSISVFEDPVDMPCGHDFCRGCWESFL-NLKI 369

  Fly   174 SEGLANTIKCPAANCEILVDYISFLKLADDSEVVERYQQLITNTFVECNMLMRWCPAPNCSHAVK 238
            .||.|:.|.|||..|..||. :..::.....|:.:||.|.....|||.|..::|||...|..||:
  Rat   370 QEGEAHNIFCPAYECFQLVP-VDVIESVVSKEMDKRYLQFDIKAFVENNPAIKWCPTAGCERAVR 433

  Fly   239 AV---------------CAEPRAVLCKCGHEFCFACGENWHEPASCSSLKKWVKK---------- 278
            ..               .....||.|..||.||:.|....|||..|.:.|.|::|
  Rat   434 LTKQGSNPSGSDTLSFPLLRAPAVDCGKGHLFCWECLGEAHEPCDCQTWKNWLQKITEMKPEELV 498

  Fly   279 ----CLEDSETSNWIAQNTKECPKCNVTIEKDGGCNHMVCKNPSCRYDFCWVCLGSWEPHGSS-- 337
                ..||:....|:..|:|.|..|...|:|:.|||||.|  ..|:|||||:||..|:.|.||
  Rat   499 GVSEAYEDAANCLWLLTNSKPCANCKSPIQKNEGCNHMQC--AKCKYDFCWICLEEWKKHSSSTG 561

  Fly   338 -WYSCNRFD-----EEEAKQARL-AQQKYR--SSMARYLHYYNRYSNHMQSLKMENKLYSNIQAK 393
             :|.|.|::     ||::|:..: |::|::  ..:.|::|||.||.||..|.::|.:|....:.|
  Rat   562 GYYRCTRYEVIQHVEEQSKEMTVEAEKKHKRFQELDRFMHYYTRYKNHEHSYQLEQRLLKTAKEK 626

  Fly   394 MDDMQEEMSWIE-----VQFLRDAVDVLCQCRTTLMYSYVFAFYL-MNNNQKIIFEDNQKDMEMA 452
            |:.:...:...|     ..|:.|||.||.:.|..|..||.:.|:| ..:.:|.|||..|.|:||.
  Rat   627 MEQLSRALKETEGGCPDTTFIEDAVHVLLKTRRILKCSYPYGFFLEPKSTKKEIFELMQTDLEMV 691

  Fly   453 TEKLSECLEREITVKNIYEVKQKVLDLSHYCQKRRHVLLCHVREGYE--------------NDW- 502
            ||.|::.:.|..    :...:.|::..:...|::|...|..|..|..              ..|
  Rat   692 TEDLAQKVNRPY----LRTPRHKIIRAACLVQQKRQEFLASVARGVAPADSPDAPRRSFAGGTWD 752

  Fly   503 WEF 505
            ||:
  Rat   753 WEY 755

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12362	NP_648392.1	IBR	208..269	CDD:214763	24/75 (32%)
CG12362	NP_648392.1	IBR	273..331	CDD:279784	26/71 (37%)
Ankib1	XP_006236111.1	ANK repeat	47..77	CDD:293786
		Ank_2	50..176	CDD:403870
		ANK repeat	79..143	CDD:293786
		ANK repeat	145..176	CDD:293786
		RING-HC_RBR_ANKIB1	333..389	CDD:319688	24/56 (43%)
		IBR	403..476	CDD:396187	22/72 (31%)
		IBR	502..553	CDD:396187	23/52 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1815
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D429758at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1756
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820