DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12362 and Cul9

DIOPT Version :9

Sequence 1:	NP_648392.1	Gene:	CG12362 / 39193	FlyBaseID:	FBgn0036082	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	XP_038939436.1	Gene:	Cul9 / 316228	RGDID:	1562008	Length:	2541	Species:	Rattus norvegicus

Alignment Length:	432	Identity:	108/432 - (25%)
Similarity:	177/432 - (40%)	Gaps:	61/432 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 KVLSVDQIVQHQRNIIDEVNNVLNLPPQVTRIILNHFKWDKESLFENYFESNPKDFFQRAHVLNP 119
            :.:|..::.......:.:|...|||.|.|.:.:|.:..|..|.|.::|.| :|:.....|.:..|
  Rat  2016 RTMSPQEVEGLMEQTVRQVQETLNLEPDVAQHLLAYSHWGTEQLLQSYSE-DPEPLLLAAGLRVP 2079

  Fly   120 FEKKIERESAASTSCAIPQLCGICFCSC---DELIGLGCGHNFCAACWKQYLANKTCSEGLANTI 181
            ..:::.         |.|..|.:|....   |:...|.|.|..|.:||.:||..: ..:......
  Rat  2080 QPQEVP---------ARPDQCPVCISPLGPNDDSPSLCCLHCCCKSCWNEYLTTR-IEQNFVLNC 2134

  Fly   182 KCPAANCEILVDYISFLKLADDSEVVERYQQLITNTFVECNMLMRWCPAP-NCSHAVKAVCAEPR 245
            .||.|:|...........:....||:.:|::.:...:||....:.||..| .|..
  Rat  2135 TCPIADCPAQPTGAFIRNIVSSPEVISKYEKALLRGYVESCSNLTWCTNPQGCDR---------- 2189

  Fly   246 AVLC-----------KCGHEFCFACG-ENWHEPASCSSLKKWVKK------CLEDSETSNWIAQN 292
             :||           |||...||.|. ...|.||||..:.:||..      ...::::.:.....
  Rat  2190 -ILCRQGLGSGTTCSKCGWASCFNCSFPEAHYPASCGHMSQWVDDGGYYDGMSVEAQSKHLAKLI 2253

  Fly   293 TKECPKCNVTIEKDGGCNHMVCKNPSCRYDFCWVCLGSWEPHGSSWYSCNRFDEEEAKQARLAQQ 357
            :|.||.|...|||:.||.||.|..  |.:.|||.||.||:|....:|:|:....:.|:|.:
  Rat  2254 SKRCPSCQAPIEKNEGCLHMTCAR--CNHGFCWRCLRSWKPSHKDYYNCSAMVSKAARQEK---- 2312

  Fly   358 KYRSSMARYLHYYNRYSNHMQSLKMENKLYSNIQAKMDDMQEEMSWIEVQFLRDAVDVLCQCRTT 422
                   |:..|..|.:.|.|:.:....|.:...| :.::....|:   .||:||...|.|.|..
  Rat  2313 -------RFQDYNERCTFHHQAREFAVNLRNQASA-IHEVPPPKSF---TFLQDACRALEQARKV 2366

  Fly   423 LMYSYVFAFYLMNNNQKIIFEDNQKDMEMATEKLSECLEREI 464
            |.|:.|::||........:.|...:::|:.|..|...||..:
  Rat  2367 LAYACVYSFYSQGTEYMDVVEQQTENLELHTNALQILLEETL 2408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12362	NP_648392.1	IBR	208..269	CDD:214763	18/73 (25%)
CG12362	NP_648392.1	IBR	273..331	CDD:279784	20/63 (32%)
Cul9	XP_038939436.1	Cul7	366..440	CDD:402903
		APC10-like	1159..1289	CDD:382862
		Cullin	<1585..1832	CDD:395716
		Cullin_Nedd8	1884..1964	CDD:416146
		RING_Ubox	2090..2141	CDD:418438	14/51 (27%)
		RING-HC finger (C3HC4-type)	2091..2141	CDD:319361	14/50 (28%)
		IBR	2162..2224	CDD:214763	18/72 (25%)
		IBR	<2255..2290	CDD:396187	18/36 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1815
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D469819at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820