Protein Alignment CG12362 and Arih2

DIOPT Version :10

• Sequence 1: NP_648392.1
• Gene: CG12362 / 39193
• FlyBaseID: FBgn0036082
• Length: 511
• Species: Drosophila melanogaster
• Sequence 2: NP_001012275.1
• Gene: Arih2 / 316005
• RGDID: 1305839
• Length: 492
• Species: Rattus norvegicus
• Alignment Length: 517
• Identity: 157/517 - (30%)
• Similarity: 271/517 - (52%)
• Gaps: 61/517 - (11%)

  Fly     1 MNSEMEFSDEDHGDSHRSLLTHMSCENDSDSEDTCTEI----------LLPENSNSPETEDFVYK 55
            |||:...|:|:..|.        :||.:.:.|:...:|          :..:.:::.:.|::.:.
  Rat     5 MNSQGSDSNEEDYDP--------NCEEEEEEEEDPGDIEDYYVGVASDVEQQGADAFDPEEYQFT 61

  Fly    56 VLSVDQ----IVQHQRNIIDEVNNVLNLPPQVTRIILNHFKWDKESLFENYFESNPKDFFQRAHV 116
            .|:..:    :.:|..::.    :.|.:...|.::||.:|.|....:.:.| .||.......|.|
  Rat    62 CLTYKESEGALHEHMTSLA----SALKVSHSVAKLILVNFHWQVSEILDRY-RSNSAQLLVEARV 121

  Fly   117 L-NPFEKKIERESAASTSCAIPQLCGIC--FCSCDELIGLGCGHNFCAACWKQYLANKTCS---- 174
            . ||        |....:...|..|.:|  |...:.|:.|.|.|.||.:||:|:     ||
  Rat   122 QPNP--------SKHVPTAHPPHHCAVCMQFVRKENLLSLTCQHQFCRSCWEQH-----CSVLVK 173

  Fly   175 EGLANTIKCPAANCEILVDYISFLKLADDSEVVERYQQLITNTFVECNMLMRWCPAPNCSHAVKA 239
            :|:...|.|.|.:|.:.........|..:.|:.::|::.:...:||.:..::.||..:|...::.
  Rat   174 DGVGVGISCMAQDCPLRTPEDFVFPLLPNEELRDKYRRYLFRDYVESHYQLQLCPGADCPMVIRV 238

  Fly   240 VCAEPRA--VLC-KCGHEFCFACGENWHEPASCSSLKKWVKKCLEDSETSNWIAQNTKECPKCNV 301
              .||||  |.| :|...|||.|.:.:|.|..|::::||:.||.:||||:|:|:.:||:|||||:
  Rat   239 --QEPRARRVQCNRCNEVFCFKCRQMYHAPTDCATIRKWLTKCADDSETANYISAHTKDCPKCNI 301

  Fly   302 TIEKDGGCNHMVCKNPSCRYDFCWVCLGSWEPHGSSWYSCNRFDEEEAKQARLAQQKYRSSMARY 366
            .|||:||||||.|.  .|::||||:|||.|:.|||.:|.|:|:.|......:..|.:.|.::.:|
  Rat   302 CIEKNGGCNHMQCS--KCKHDFCWMCLGDWKTHGSEYYECSRYKENPDIVNQSQQAQAREALKKY 364

  Fly   367 LHYYNRYSNHMQSLKMENKLYSNIQAKMDD--MQEEMSWIEVQFLRDAVDVLCQCRTTLMYSYVF 429
            |.|:.|:.||.:||::|.:.|..|..|:.:  |....:||:.|:|::|..:|.:||.||.|:|.:
  Rat   365 LFYFERWENHNKSLQLEAQTYQRIHEKIQERVMNNLGTWIDWQYLQNAAKLLAKCRYTLQYTYPY 429

  Fly   430 AFYLMNNNQKIIFEDNQKDMEMATEKLSECLEREITVKNIYEVKQKVLDLSHYCQKRRHVLL 491
            |:|:.:..:|.:||..|..:|...|.||..:||    .:.|: :..:.:..|..::||..||
  Rat   430 AYYMESGPRKKLFEYQQAQLEAEIENLSWKVER----ADSYD-RGDLENQMHIAEQRRRTLL 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12362	NP_648392.1	RING-HC_RBR_HHARI	138..194	CDD:438288	19/61 (31%)
		BRcat_RBR_HHARI-like	203..284	CDD:439004	26/83 (31%)
		Rcat_RBR_HHARI-like	288..345	CDD:439017	33/56 (59%)
		Ariadne	346..>480	CDD:466073	41/135 (30%)
Arih2	NP_001012275.1	RING-HC_RBR_TRIAD1	136..189	CDD:438429	19/57 (33%)
		BRcat_RBR_TRIAD1	216..287	CDD:439005	27/72 (38%)
		Rcat_RBR_TRIAD1	291..346	CDD:439021	33/56 (59%)
		Ariadne	351..>477	CDD:466073	40/130 (31%)