DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12362 and Rnf19a

DIOPT Version :9

Sequence 1:	NP_648392.1	Gene:	CG12362 / 39193	FlyBaseID:	FBgn0036082	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_038951.1	Gene:	Rnf19a / 30945	MGIID:	1353623	Length:	840	Species:	Mus musculus

Alignment Length:	359	Identity:	85/359 - (23%)
Similarity:	143/359 - (39%)	Gaps:	90/359 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 DSHRSLLT------HMSCENDSDSEDTCTEILLPENSNSPETEDFVYKVLSVDQIVQHQRNI--- 69
            ||...|::      |....:|.|.:.:.:.:.||....:|:     .:.:|:..:.:.:::.
Mouse    21 DSDSILMSILDMSLHQQMGSDRDLQSSTSSVSLPSVKKAPK-----QRRISIGSLFRRKKDSKRK 80

  Fly    70 -------IDEVNNVLNLPPQVTRIILNHFKWDKESLF------ENYFESNPK---DFFQRAHVLN 118
                   :|.:.::.::..::..        ||.|:|      :|...|..|   ||.:
Mouse    81 SRELNGGVDGIASIESIHSEMCA--------DKNSIFSTNTSSDNGLTSISKQIGDFIE------ 131

  Fly   119 PFEKKIERESAASTSCAIPQLCGICFC--SCDELIG-LGCGHNFCAACWKQYLANKTCSEGLANT 180
                                 |.:|..  |.|.... :.|.|..|..|.:|||..: .||...|
Mouse   132 ---------------------CPLCLLRHSKDRFPDIMTCHHRSCVDCLRQYLRIE-ISESRVN- 173

  Fly   181 IKCPAANCEILVDYISFLKLADDSEVVERYQQLITNTFVECNMLMRWCPAPNCSHAVKAV-CAEP 244
            |.||  .|....:......:..|..::|:|::.:...::..:...||||||:|.:||.|. ||..
Mouse   174 ISCP--ECTERFNPHDIRLILSDDVLMEKYEEFMLRRWLVADPDCRWCPAPDCGYAVIAFGCASC 236

  Fly   245 RAVLC---KCGHEFCFACGENWHEPASCSS----------LKKWVKKCLEDSETSNWIAQNTKEC 296
            ..:.|   .||.|||:.|.:.||...:|.:          |:......:..|:.|...|.:.|.|
Mouse   237 PKLTCGREGCGTEFCYHCKQIWHPNQTCDAARQERAQSLRLRTIRSSSISYSQESGAAADDIKPC 301

  Fly   297 PKCNVTIEK--DGGCNHMVCKNPSCRYDFCWVCL 328
            |:|...|.|  ||.||||.|  ..|..:|||:|:
Mouse   302 PRCAAYIIKMNDGSCNHMTC--AVCGCEFCWLCM 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12362	NP_648392.1	IBR	208..269	CDD:214763	23/64 (36%)
CG12362	NP_648392.1	IBR	273..331	CDD:279784	21/58 (36%)
Rnf19a	NP_038951.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..61		4/20 (20%)
		TRIAD supradomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01221	128..351		67/239 (28%)
		RING	132..179	CDD:214546	17/50 (34%)
		IBR	199..264	CDD:214763	23/64 (36%)
		IBR	<297..335	CDD:279784	18/39 (46%)
		AzlC	<361..450	CDD:294385
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	625..685
		Interaction with CASR. /evidence=ECO:0000250	660..840
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	700..721
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	786..808
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1815
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810