Protein Alignment CG12362 and ARIH1

DIOPT Version :10

• Sequence 1: NP_648392.1
• Gene: CG12362 / 39193
• FlyBaseID: FBgn0036082
• Length: 511
• Species: Drosophila melanogaster
• Sequence 2: NP_005735.2
• Gene: ARIH1 / 25820
• HGNCID: 689
• Length: 557
• Species: Homo sapiens
• Alignment Length: 465
• Identity: 265/465 - (56%)
• Similarity: 341/465 - (73%)
• Gaps: 6/465 - (1%)

  Fly    48 ETEDFVYKVLSVDQIVQHQRNIIDEVNNVLNLPPQVTRIILNHFKWDKESLFENYFESNPKDFFQ 112
            :.||:.|:||:.:||:||....|.|||.|:..|..:|||:|:||.||||.|.|.||:.|.:..|.
Human    95 QEEDYRYEVLTAEQILQHMVECIREVNEVIQNPATITRILLSHFNWDKEKLMERYFDGNLEKLFA 159

  Fly   113 RAHVLNPFEKKIERE-SAASTSCAIPQLCGICFCSCDE--LIGLGCGHNFCAACWKQYLANKTCS 174
            ..||:||.:|...|: :..|::..:|  |.||:.:...  ..||.|||.||..||.:||..|...
Human   160 ECHVINPSKKSRTRQMNTRSSAQDMP--CQICYLNYPNSYFTGLECGHKFCMQCWSEYLTTKIME 222

  Fly   175 EGLANTIKCPAANCEILVDYISFLKLADDSEVVERYQQLITNTFVECNMLMRWCPAPNCSHAVKA 239
            ||:..||.|||..|:||||..:.::|..||:|..:||.||||:|||||.|::|||||:|.|.||.
Human   223 EGMGQTISCPAHGCDILVDDNTVMRLITDSKVKLKYQHLITNSFVECNRLLKWCPAPDCHHVVKV 287

  Fly   240 VCAEPRAVLCKCGHEFCFACGENWHEPASCSSLKKWVKKCLEDSETSNWIAQNTKECPKCNVTIE 304
            ...:.:.|.||||.:|||.||||||:|..|..||||:|||.:|||||||||.||||||||:||||
Human   288 QYPDAKPVRCKCGRQFCFNCGENWHDPVKCKWLKKWIKKCDDDSETSNWIAANTKECPKCHVTIE 352

  Fly   305 KDGGCNHMVCKNPSCRYDFCWVCLGSWEPHGSSWYSCNRFDEEEAKQARLAQQKYRSSMARYLHY 369
            ||||||||||:|.:|:.:|||||||.||||||:||:|||::|::||.||.||::.|:::.|||.|
Human   353 KDGGCNHMVCRNQNCKAEFCWVCLGPWEPHGSAWYNCNRYNEDDAKAARDAQERSRAALQRYLFY 417

  Fly   370 YNRYSNHMQSLKMENKLYSNIQAKMDDMQE-EMSWIEVQFLRDAVDVLCQCRTTLMYSYVFAFYL 433
            .|||.||||||:.|:|||:.::.||::||: .|||||||||:.|||||||||.||||:|||||||
Human   418 CNRYMNHMQSLRFEHKLYAQVKQKMEEMQQHNMSWIEVQFLKKAVDVLCQCRATLMYTYVFAFYL 482

  Fly   434 MNNNQKIIFEDNQKDMEMATEKLSECLEREITVKNIYEVKQKVLDLSHYCQKRRHVLLCHVREGY 498
            ..|||.||||:||.|:|.|||.||..|||:|:..::.::||||.|...||:.||.|||.||.|||
Human   483 KKNNQSIIFENNQADLENATEVLSGYLERDISQDSLQDIKQKVQDKYRYCESRRRVLLQHVHEGY 547

  Fly   499 ENDWWEFKEE 508
            |.|.||:.|:
Human   548 EKDLWEYIED 557

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12362	NP_648392.1	RING-HC_RBR_HHARI	138..194	CDD:438288	26/57 (46%)
		BRcat_RBR_HHARI-like	203..284	CDD:439004	48/80 (60%)
		Rcat_RBR_HHARI-like	288..345	CDD:439017	45/56 (80%)
		Ariadne	346..>480	CDD:466073	83/134 (62%)
ARIH1	NP_005735.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..95		265/465 (57%)
		UBA-like. /evidence=ECO:0000305|PubMed:23707686	105..153		24/47 (51%)
		TRIAD supradomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU01221	182..393		127/212 (60%)
		RING-HC_RBR_HHARI	184..242	CDD:438288	27/59 (46%)
		BRcat_RBR_HHARI-like	251..332	CDD:439004	48/80 (60%)
		Rcat_RBR_HHARI-like	336..393	CDD:439017	45/56 (80%)
		Ariadne	394..>525	CDD:466073	80/130 (62%)
		Ariadne domain. /evidence=ECO:0000305|PubMed:23707686	408..557		92/148 (62%)