DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12362 and Rbck1

DIOPT Version :9

Sequence 1:	NP_648392.1	Gene:	CG12362 / 39193	FlyBaseID:	FBgn0036082	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_001077390.1	Gene:	Rbck1 / 24105	MGIID:	1344372	Length:	508	Species:	Mus musculus

Alignment Length:	274	Identity:	61/274 - (22%)
Similarity:	100/274 - (36%)	Gaps:	61/274 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 LNHFKWDKESLFE-NYFESNPKDFFQRAHVLNPFEKKIERESAASTSCAIPQLCGICF---CSCD 148
            |..::..|:...| ||.:....:  ||:.|||                ..|..|.:|:   ...:
Mouse   245 LRQYQQRKQQQQEGNYLQHVQLE--QRSLVLN----------------TEPTECPVCYSVLAPGE 291

  Fly   149 ELIGLGCGHNFCAACWKQYLANKTCSE----GLANTIKCPAANCEILVDYISFLKLADDSEVVER 209
            .::...|.|.||..|.:..:.|...:|    .:.:|..||.   ::|...|..|...:|   .:|
Mouse   292 AVVLRECLHTFCRECLQGTIRNSQEAEVACPFIDSTYSCPG---KLLEREIRALLSPED---YQR 350

  Fly   210 YQQLITNTFVECNMLMRWCPAPNC----------SHAVKAVCAEPRAVLCKCGHEFCFACGENWH 264
            :..|..:.....:.|...|..|:|          :.....||.....:|||..||. ..|.|...
Mouse   351 FLDLGVSIAENRSTLSYHCKTPDCRGWCFFEDDVNEFTCPVCTRVNCLLCKAIHEH-MNCREYQD 414

  Fly   265 EPA-------SCSSLKKWVKKCLEDSETSNWIAQNTKECPKCNVTIEKDGGCNHMVCKNPSCRYD 322
            :.|       :.....:.:|..|:..|..:        ||:|.:.::|..||:.:.|  ..|..:
Mouse   415 DLALRAQNDVAARQTTEMLKVMLQQGEAMH--------CPQCRIVVQKKDGCDWIRC--TVCHTE 469

  Fly   323 FCWVCLG-SWEPHG 335
            .|||..| .|.|.|
Mouse   470 ICWVTKGPRWGPGG 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12362	NP_648392.1	IBR	208..269	CDD:214763	16/77 (21%)
CG12362	NP_648392.1	IBR	273..331	CDD:279784	15/58 (26%)
Rbck1	NP_001077390.1	Interaction with TAB2. /evidence=ECO:0000250\|UniProtKB:Q9BYM8	1..268		5/24 (21%)
		Interaction with IRF3. /evidence=ECO:0000250\|UniProtKB:Q9BYM8	1..218
		Hoil1_N	57..131	CDD:176394
		Interaction with RNF31. /evidence=ECO:0000250\|UniProtKB:Q9BYM8	69..131
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	163..191
		ZnF_RBZ	195..215	CDD:197784
		RanBP2-type Zn finger	195..214	CDD:275376
		TRIAD supradomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01221	276..504		51/225 (23%)
		zf-RING_UBOX	280..322	CDD:290181	9/41 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1815
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900