DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12362 and Arih1

DIOPT Version :9

Sequence 1:	NP_648392.1	Gene:	CG12362 / 39193	FlyBaseID:	FBgn0036082	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_064311.2	Gene:	Arih1 / 23806	MGIID:	1344363	Length:	555	Species:	Mus musculus

Alignment Length:	465	Identity:	265/465 - (56%)
Similarity:	341/465 - (73%)	Gaps:	6/465 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 ETEDFVYKVLSVDQIVQHQRNIIDEVNNVLNLPPQVTRIILNHFKWDKESLFENYFESNPKDFFQ 112
            :.||:.|:||:.:||:||....|.|||.|:..|..:|||:|:||.||||.|.|.||:.|.:..|.
Mouse    93 QEEDYRYEVLTAEQILQHMVECIREVNEVIQNPATITRILLSHFNWDKEKLMERYFDGNLEKLFA 157

  Fly   113 RAHVLNPFEKKIERE-SAASTSCAIPQLCGICFCSCDE--LIGLGCGHNFCAACWKQYLANKTCS 174
            ..||:||.:|...|: :..|::..:|  |.||:.:...  ..||.|||.||..||.:||..|...
Mouse   158 ECHVINPSKKSRTRQMNTRSSAQDMP--CQICYLNYPNSYFTGLECGHKFCMQCWSEYLTTKIME 220

  Fly   175 EGLANTIKCPAANCEILVDYISFLKLADDSEVVERYQQLITNTFVECNMLMRWCPAPNCSHAVKA 239
            ||:..||.|||..|:||||..:.::|..||:|..:||.||||:|||||.|::|||||:|.|.||.
Mouse   221 EGMGQTISCPAHGCDILVDDNTVMRLITDSKVKLKYQHLITNSFVECNRLLKWCPAPDCHHVVKV 285

  Fly   240 VCAEPRAVLCKCGHEFCFACGENWHEPASCSSLKKWVKKCLEDSETSNWIAQNTKECPKCNVTIE 304
            ...:.:.|.||||.:|||.||||||:|..|..||||:|||.:|||||||||.||||||||:||||
Mouse   286 QYPDAKPVRCKCGRQFCFNCGENWHDPVKCKWLKKWIKKCDDDSETSNWIAANTKECPKCHVTIE 350

  Fly   305 KDGGCNHMVCKNPSCRYDFCWVCLGSWEPHGSSWYSCNRFDEEEAKQARLAQQKYRSSMARYLHY 369
            ||||||||||:|.:|:.:|||||||.||||||:||:|||::|::||.||.||::.|:::.|||.|
Mouse   351 KDGGCNHMVCRNQNCKAEFCWVCLGPWEPHGSAWYNCNRYNEDDAKAARDAQERSRAALQRYLFY 415

  Fly   370 YNRYSNHMQSLKMENKLYSNIQAKMDDMQE-EMSWIEVQFLRDAVDVLCQCRTTLMYSYVFAFYL 433
            .|||.||||||:.|:|||:.::.||::||: .|||||||||:.|||||||||.||||:|||||||
Mouse   416 CNRYMNHMQSLRFEHKLYAQVKQKMEEMQQHNMSWIEVQFLKKAVDVLCQCRATLMYTYVFAFYL 480

  Fly   434 MNNNQKIIFEDNQKDMEMATEKLSECLEREITVKNIYEVKQKVLDLSHYCQKRRHVLLCHVREGY 498
            ..|||.||||:||.|:|.|||.||..|||:|:..::.::||||.|...||:.||.|||.||.|||
Mouse   481 KKNNQSIIFENNQADLENATEVLSGYLERDISQDSLQDIKQKVQDKYRYCESRRRVLLQHVHEGY 545

  Fly   499 ENDWWEFKEE 508
            |.|.||:.|:
Mouse   546 EKDLWEYIED 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12362	NP_648392.1	IBR	208..269	CDD:214763	36/60 (60%)
CG12362	NP_648392.1	IBR	273..331	CDD:279784	46/57 (81%)
Arih1	NP_064311.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..93		265/465 (57%)
		UBA-like. /evidence=ECO:0000250\|UniProtKB:Q9Y4X5	103..151		24/47 (51%)
		TRIAD supradomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01221	180..391		127/212 (60%)
		RING-HC_RBR_HHARI	183..240	CDD:319540	27/58 (47%)
		IBR	255..315	CDD:214763	36/59 (61%)
		IBR	<337..377	CDD:396187	31/39 (79%)
		Ariadne domain. /evidence=ECO:0000250\|UniProtKB:Q9Y4X5	406..555		92/148 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850393
Domainoid	1	1.000	144	1.000	Domainoid score	I4617
eggNOG	1	0.900	-	-		E1_KOG1815
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54219
OrthoDB	1	1.010	-	-		D429758at33208
OrthoFinder	1	1.000	-	-		FOG0000379
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100963
Panther	1	1.100	-	-	O	PTHR11685
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.720