Protein Alignment CG12362 and ari-1.1

DIOPT Version :10

• Sequence 1: NP_648392.1
• Gene: CG12362 / 39193
• FlyBaseID: FBgn0036082
• Length: 511
• Species: Drosophila melanogaster
• Sequence 2: NP_491749.2
• Gene: ari-1.1 / 172284
• WormBaseID: WBGene00016158
• Length: 494
• Species: Caenorhabditis elegans
• Alignment Length: 515
• Identity: 242/515 - (46%)
• Similarity: 323/515 - (62%)
• Gaps: 29/515 - (5%)

  Fly     1 MNSEMEFSDEDHGDSHRSLLTHMSCENDSDS------EDTCTEILLPENSNSPETEDFVYKVLSV 59
            |:|:.|.:.:|...|...:  ...|.:|.|.      |...::.   :::..|:.|     ||:.
 Worm     1 MSSDDEINMDDSDSSQGEI--DDGCMSDDDGIVLESREQNSSDY---KDNGEPDNE-----VLNH 55

  Fly    60 DQIVQHQRNIIDEVNNVLNLPPQVTRIILNHFKWDKESLFENYFE-SNPKDFFQRAHVLNPFEKK 123
            |.:....:..|.:|..||.:...|.||:|:.:||:||||.|.::| .:...|...|||:   .::
 Worm    56 DSLEAEMKKTITDVQAVLQVKTGVCRILLHKYKWNKESLLERFYEHPDTTTFLIDAHVI---PRR 117

  Fly   124 IERESAASTSCAIPQLCGICFCSCDELIGLGCGHNFCAACWKQYLANKTCSEGLANTIKCPAANC 188
            .||..|....      |.|| ||..||.||.|.|..|..|||.||.||..:.. .:.|:|.|.||
 Worm   118 QERLPAGDAE------CDIC-CSLGELSGLSCNHRACTQCWKAYLTNKIANNA-QSEIECMAPNC 174

  Fly   189 EILVDYISFLKLADDSEVVERYQQLITNTFVECNMLMRWCPAPNCSHAVKAVCAEPRAVLCKCGH 253
            ::|::....:....|..|:..|::||..::||.|.|::|||..:|..||:....|||.|:|.||.
 Worm   175 KLLIEDEKVMFYITDPTVIATYRKLIVASYVETNRLLKWCPGIDCGKAVRVSHWEPRLVVCSCGS 239

  Fly   254 EFCFACGENWHEPASCSSLKKWVKKCLEDSETSNWIAQNTKECPKCNVTIEKDGGCNHMVCKNPS 318
            .|||:||.:||||.:|..||.|:|||.:||||||||..||||||||.:|||||||||||.|||.:
 Worm   240 RFCFSCGHDWHEPVNCRLLKLWLKKCNDDSETSNWINANTKECPKCMITIEKDGGCNHMTCKNTA 304

  Fly   319 CRYDFCWVCLGSWEPHGSSWYSCNRFDEEEAKQARLAQQKYRSSMARYLHYYNRYSNHMQSLKME 383
            ||::|||:|||.|||||||||||||||:..||.||.||:..|:::.|||.|||||..|.|||::|
 Worm   305 CRFEFCWMCLGPWEPHGSSWYSCNRFDDSAAKNARDAQEVSRANLQRYLFYYNRYMGHQQSLRLE 369

  Fly   384 NKLYSNIQAKMDDMQE-EMSWIEVQFLRDAVDVLCQCRTTLMYSYVFAFYLMNNNQKIIFEDNQK 447
            .|||:.:::||:.||. .||||||||||.|||||.:||.|||::|.|||||..:|..||||.|||
 Worm   370 GKLYATVKSKMEQMQTLSMSWIEVQFLRKAVDVLSECRRTLMFTYAFAFYLKRDNNAIIFESNQK 434

  Fly   448 DMEMATEKLSECLEREITVKNIYEVKQKVLDLSHYCQKRRHVLLCHVREGYENDWWEFKE 507
            |:||.||:||..|||::..:|:..:||||.|...|.:.||.|||.|..||.:.:.|.|.|
 Worm   435 DLEMETEQLSGFLERDLDNENLVTLKQKVQDKYRYVEHRRKVLLDHCSEGADQELWVFNE 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12362	NP_648392.1	RING-HC_RBR_HHARI	138..194	CDD:438288	25/55 (45%)
		BRcat_RBR_HHARI-like	203..284	CDD:439004	39/80 (49%)
		Rcat_RBR_HHARI-like	288..345	CDD:439017	45/56 (80%)
		Ariadne	346..>480	CDD:466073	77/134 (57%)
ari-1.1	NP_491749.2	RING-HC_RBR_TRIAD1	127..176	CDD:438429	24/56 (43%)
		BRcat_RBR_HHARI-like	189..270	CDD:439004	39/80 (49%)
		Rcat_RBR_HHARI-like	274..331	CDD:439017	45/56 (80%)
		Ariadne	341..>453	CDD:466073	67/111 (60%)