DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12362 and RNF19B

DIOPT Version :9

Sequence 1:	NP_648392.1	Gene:	CG12362 / 39193	FlyBaseID:	FBgn0036082	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_699172.2	Gene:	RNF19B / 127544	HGNCID:	26886	Length:	732	Species:	Homo sapiens

Alignment Length:	251	Identity:	67/251 - (26%)
Similarity:	103/251 - (41%)	Gaps:	53/251 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 PFEKKIERESAASTSCAIPQL-----------------CGICFCSCDELIG---------LGCGH 157
            |.|...|.|:.|:.:.|.|..                 |.:|      |:.         |.|.|
Human    81 PAEPAAEAEAEAAAAAAEPGFDDEEAAEGGGPGAEEVECPLC------LVRLPPERAPRLLSCPH 139

  Fly   158 NFCAACWKQYLANKTCSEGLANTIKCPAANCEILVDYISFLKLADDSEVVERYQQLITNTFVECN 222
            ..|..|.:.||..:.....:  .|.||  .|...::......|..|..::.:|::.:...::..:
Human   140 RSCRDCLRHYLRLEISESRV--PISCP--ECSERLNPHDIRLLLADPPLMHKYEEFMLRRYLASD 200

  Fly   223 MLMRWCPAPNCSHAVKAV-CAEPRAVLCK---CGHEFCFACGENWHEPASCSSLKKWVKKCL--E 281
            ...||||||:|.:||.|. ||....:.|:   |..|||:.|.:.||...:|...::...:.|  .
Human   201 PDCRWCPAPDCGYAVIAYGCASCPKLTCEREGCQTEFCYHCKQIWHPNQTCDMARQQRAQTLRVR 265

  Fly   282 DSETS-------NWIAQNTKECPKCNVTIEK--DGGCNHMVCKNPSCRYDFCWVCL 328
            ...||       :..|.:.|.||:|:..|.|  ||.||||.|  ..|..:|||:|:
Human   266 TKHTSGLSYGQESGPADDIKPCPRCSAYIIKMNDGSCNHMTC--AVCGCEFCWLCM 319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12362	NP_648392.1	IBR	208..269	CDD:214763	21/64 (33%)
CG12362	NP_648392.1	IBR	273..331	CDD:279784	22/67 (33%)
RNF19B	NP_699172.2	Required for ubiquitin ligase activity and for protection against staurosporin-induced cell death. /evidence=ECO:0000269\|PubMed:27485036	1..318		66/248 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..112		7/30 (23%)
		TRIAD supradomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01221	115..337		60/217 (28%)
		zf-RING_2	118..166	CDD:290367	13/57 (23%)
		IBR	187..251	CDD:214763	21/63 (33%)
		IBR	<283..321	CDD:279784	18/39 (46%)
		AzlC	<347..436	CDD:294385
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	618..732
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1815
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810